RGD Reference Report - Expression of p21Cip1/Waf1 and p27Kip1 in small cell neuroendocrine carcinoma of the uterine cervix. - Rat Genome Database

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Expression of p21Cip1/Waf1 and p27Kip1 in small cell neuroendocrine carcinoma of the uterine cervix.

Authors: Kataoka, TR  Tsukamoto, Y  Matsumura, M  Miyake, A  Kamiura, S  Ishiguro, S  Nishizawa, Y 
Citation: Kataoka TR, etal., Int J Surg Pathol. 2008 Jan;16(1):11-5.
RGD ID: 2289651
Pubmed: PMID:18203777   (View Abstract at PubMed)
DOI: DOI:10.1177/1066896907309574   (Journal Full-text)

Small-cell neuroendocrine carcinoma of the uterine cervix (SCCC), a rare but malignant cervical neoplasm, has a highly aggressive phenotype that requires more intensive treatment than other cervical tumors. Immunohistochemical methods were used to compare the expression of p21Cip1/Waf1 and p27Kip1 in SCCC and squamous cell carcinoma, the most common type of cervical cancer. In SCCC, p21 expression was significantly reduced compared with squamous cell carcinoma, whereas expression of p27 was similar in both carcinomas. Reduced expression of p21 could be a helpful diagnostic marker and may contribute to the invasive phenotype of SCCC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Uterine Cervical Neoplasms  IEP 2289651protein:decreased expression:uterine cervixRGD 
Uterine Cervical Neoplasms  ISOCDKN1A (Homo sapiens)2289651; 2289651protein:decreased expression:uterine cervixRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn1a  (cyclin-dependent kinase inhibitor 1A)

Genes (Mus musculus)
Cdkn1a  (cyclin dependent kinase inhibitor 1A)

Genes (Homo sapiens)
CDKN1A  (cyclin dependent kinase inhibitor 1A)


Additional Information