RGD Reference Report - Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes. - Rat Genome Database

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Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes.

Authors: Pihlajamaki, J  Salmenniemi, U  Vanttinen, M  Ruotsalainen, E  Kuusisto, J  Vauhkonen, I  Kainulainen, S  Ng, MC  Cox, NJ  Bell, GI  Laakso, M 
Citation: Pihlajamaki J, etal., Diabetologia. 2006 Jul;49(7):1560-6. Epub 2006 May 12.
RGD ID: 1625047
Pubmed: PMID:16752174   (View Abstract at PubMed)
DOI: DOI:10.1007/s00125-006-0270-z   (Journal Full-text)

AIMS/HYPOTHESIS: The mechanisms by which the calpain-10 gene (CAPN10) affects the risk of type 2 diabetes are unclear. Therefore, we investigated the effects of four polymorphisms in CAPN10 (single nucleotide polymorphism [SNP]-43, SNP-44, Insertion/Deletion [Indel]-19 and SNP-63) on insulin secretion, insulin action and abdominal fat distribution in offspring of patients with type 2 diabetes. SUBJECTS AND METHODS: Insulin secretion was determined by an IVGTT, insulin action by the hyperinsulinaemic-euglycaemic clamp and abdominal fat distribution by computed tomography in 158 non-diabetic offspring (age 34.9+/-6.3 years [mean+/-SD], BMI 26.2+/-4.9 kg/m(2)) of type 2 diabetic patients. RESULTS: SNP-43 (p=0.009 over the three genotypes, adjusted for age, sex, BMI and family relationship) and haplotypes carrying the A allele of SNP-43 were associated with intra-abdominal fat area. The A allele of SNP-43 was associated with intra-abdominal fat area in men (p=0.014) but not in women. SNP-44, InDel-19 and SNP-63 were not associated with intra-abdominal fat area or insulin action. Furthermore, we demonstrated in a separate sample of middle-aged men (n=234) who had a history of type 2 diabetes in first-degree relatives that the A allele of SNP-43 was associated with a large waist circumference, and high insulin levels in an OGTT. CONCLUSIONS/INTERPRETATION: SNP-43 of CAPN10 may contribute to the risk of diabetes by regulating abdominal obesity in subjects with high risk of type 2 diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  IAGP 1625047DNA:SNPsRGD 
obesity  ISOCAPN10 (Homo sapiens)1625047; 1625047DNA:SNPsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Capn10  (calpain 10)

Genes (Mus musculus)
Capn10  (calpain 10)

Genes (Homo sapiens)
CAPN10  (calpain 10)


Additional Information