RGD Reference Report - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine - Rat Genome Database

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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine

Authors: Wang, Q  Wang, KZ  Wang, GY 
Citation: Wang Q, etal., Zhong Xi Yi Jie He Xue Bao. 2006 May;4(3):303-6.
RGD ID: 1624172
Pubmed: PMID:16696921   (View Abstract at PubMed)

OBJECTIVE: To investigate the effects of soybean isoflavones (SI) on expression levels of osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) mRNAs in bone tissues of ovariectomized rats, and to discuss the mechanism of soybean isoflavaones in preventing and treating postmenopausal osteoporosis (PMO). METHODS: Thirty adult SD rats were randomly divided into 3 groups: sham-operation group, untreated group and SI-treated group. The rats in the last two groups were bilaterally ovariectomized. The bone density of L(3) to L(6) vertebrae was detected after 12-week intervention. Total RNA was extracted from femur head and the expression levels of OPG and OPGL mRNAs were examined by real-time quantitative polymerase chain reaction. RESULTS: SI could increase the bone density of lumbar vertebrae in ovariectomized rats, up-regulate the expression level of OPG mRNA and down-regulate the ratio of OPGL mRNA/OPG mRNA, but exert no significant effect on the expression of OPGL mRNA. CONCLUSION: The therapeutic effects of SI on PMO may be related to regulating the expression levels of OPG and OPGL mRNAs, and the ratio of OPGL mRNA/OPG mRNA.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient  IEP 1624172 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnfrsf11b  (TNF receptor superfamily member 11B)


Additional Information