RGD Reference Report - Elevated expression of matrix metalloproteinase-13 in abdominal aortic aneurysms. - Rat Genome Database

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Elevated expression of matrix metalloproteinase-13 in abdominal aortic aneurysms.

Authors: Tromp, G  Gatalica, Z  Skunca, M  Berguer, R  Siegel, T  Kline, RA  Kuivaniemi, H 
Citation: Tromp G, etal., Ann Vasc Surg. 2004 Jul;18(4):414-20.
RGD ID: 1582548
Pubmed: PMID:15156361   (View Abstract at PubMed)
DOI: DOI:10.1007/s10016-004-0050-5   (Journal Full-text)

Destructive remodeling of extracellular matrix has been shown to be present in aneurysmal abdominal aorta. We used real-time quantitative reverse transcriptase polymerase chain reaction to determine the relative expression of matrix metalloproteinase-13 (MMP13) in aortic tissue samples from patients who underwent abdominal aortic aneurysm repair operations (n = 36) and from nonaneurysmal autopsy samples (n = 20). The assays were carried out simultaneously in the same reaction tubes for ribosomal 18S RNA to correct for different amounts of input RNA. MMP13 was expressed in all parts of aorta and its expression was elevated in aneurysmal sac. In further studies using MMP13-specific antibody we demonstrated that MMP13 protein was present in the aneurysmal wall.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abdominal aortic aneurysm  IDA 1582548 RGD 
abdominal aortic aneurysm  ISOMMP13 (Homo sapiens)1582548; 1582548 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp13  (matrix metallopeptidase 13)

Genes (Mus musculus)
Mmp13  (matrix metallopeptidase 13)

Genes (Homo sapiens)
MMP13  (matrix metallopeptidase 13)


Additional Information