RGD Reference Report - Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. - Rat Genome Database

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Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1.

Authors: Miki, T  Suzuki, M  Shibasaki, T  Uemura, H  Sato, T  Yamaguchi, K  Koseki, H  Iwanaga, T  Nakaya, H  Seino, S 
Citation: Miki T, etal., Nat Med. 2002 May;8(5):466-72.
RGD ID: 1581700
Pubmed: PMID:11984590   (View Abstract at PubMed)
DOI: DOI:10.1038/nm0502-466   (Journal Full-text)

The inwardly rectifying K(+) channel Kir6.1 forms K(+) channels by coupling with a sulfonylurea receptor in reconstituted systems, but the physiological roles of Kir6.1-containing K(+) channels have not been determined. We report here that mice lacking the gene encoding Kir6.1 (known as Kcnj8) have a high rate of sudden death associated with spontaneous ST elevation followed by atrioventricular block as seen on an electrocardiogram. The K(+) channel opener pinacidil did not induce K(+) currents in vascular smooth-muscle cells of Kir6.1-null mice, and there was no vasodilation response to pinacidil. The administration of methylergometrine, a vasoconstrictive agent, elicited ST elevation followed by cardiac death in Kir6.1-null mice but not in wild-type mice, indicating a phenotype characterized by hypercontractility of coronary arteries and resembling Prinzmetal (or variant) angina in humans. The Kir6.1-containing K(+) channel is critical in the regulation of vascular tonus, especially in the coronary arteries, and its disruption may cause Prinzmetal angina.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Prinzmetal angina  ISOKcnj8 (Mus musculus)1581700; 1581700 RGD 
Prinzmetal angina  IDA 1581700 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnj8  (potassium inwardly-rectifying channel, subfamily J, member 8)

Genes (Mus musculus)
Kcnj8  (potassium inwardly-rectifying channel, subfamily J, member 8)

Genes (Homo sapiens)
KCNJ8  (potassium inwardly rectifying channel subfamily J member 8)


Additional Information