RGD Reference Report - Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP-dependent Lon protease. - Rat Genome Database

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Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP-dependent Lon protease.

Authors: Luciakova, K  Sokolikova, B  Chloupkova, M  Nelson, BD 
Citation: Luciakova K, etal., FEBS Lett. 1999 Feb 12;444(2-3):186-8.
RGD ID: 1580666
Pubmed: PMID:10050756   (View Abstract at PubMed)

Rats bearing the Zajdela hepatoma tumor and T3-treated hypothyroid rats were used to study the role of protein degradation in the process of mitochondrial biogenesis. It was shown that the activity, protein and mRNA levels of the ATP-dependent Lon protease increased in rapidly growing Zajdela hepatoma cells. The increase in the rate of mitochondrial biogenesis by thyroid hormone was similarly accompanied by enhanced expression of the Lon protease. The results imply that mitochondrial biogenesis in mammalian cells is, at least partially, regulated by the matrix Lon protease.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mitochondrion organization  IEP 1580666 RGD 
response to hormone  IEP 1580666 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lonp1  (lon peptidase 1, mitochondrial)


Additional Information