RGD Reference Report - MicroRNA-432-5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer. - Rat Genome Database

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MicroRNA-432-5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer.

Authors: Luo, Man  Hu, Zuowei  Kong, Yuefeng  Li, Lingyi 
Citation: Luo M, etal., Exp Ther Med. 2021 Apr;21(4):301. doi: 10.3892/etm.2021.9732. Epub 2021 Jan 29.
RGD ID: 152999433
Pubmed: PMID:33717244   (View Abstract at PubMed)
PMCID: PMC7885074   (View Article at PubMed Central)
DOI: DOI:10.3892/etm.2021.9732   (Journal Full-text)

MicroRNAs (miRNAs) play an important role in the occurrence and development of colorectal cancer (CRC). Evidence shows that miR-432-5p expression is decreased in various tumors and cancer cell lines. miR-432-5p can inhibit tumor invasion and metastasis, but its role in colorectal cancer is unclear. The present study demonstrated that miR-432-5p expression was decreased in colorectal cancer tissue and cell lines, and is negatively associated with invasion classification, lymph node metastasis and Tumor-Node-Metastasis stage. Kaplan-Meier survival analysis showed that low miR-432-5p expression was associated with a poor survival rate in patients with CRC. In addition, SW480 and HT-29 cells transfected with miR-432-5p mimics had decreased migration and invasion abilities, whereas miR-432-5p inhibitors had the opposite effect. The expression of C-X-C motif chemokine ligand 5 (CXCL5), a direct target of miR-432-5p, was negatively associated with miR-432-5p expression. When CXCL5 was introduced into miR-432-5p mimic-transfected SW480 and HT-29 cells, miR-432-5p-mediated inhibition of CRC migration and invasion was reversed. Thus, the present results suggest that miR-432-5p can inhibit the migration and invasion of CRC cells by targeting CXCL5.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colorectal cancer  IEP 152999433mRNA:increased expression:colon (human)RGD 
colorectal cancer disease_progressionIEP 152999433mRNA:decreased expression:colon (human)RGD 
colorectal cancer disease_progressionISOMIR432 (Homo sapiens)152999433mRNA:decreased expression:colon (human)RGD 
Lymphatic Metastasis disease_progressionIEP 152999433mRNA:decreased expression:colon (human)RGD 
Lymphatic Metastasis disease_progressionISOMIR432 (Homo sapiens)152999433mRNA:decreased expression:colon (human)RGD 

Objects Annotated

Genes (Mus musculus)
Mir432  (microRNA 432)

Genes (Homo sapiens)
CXCL5  (C-X-C motif chemokine ligand 5)
MIR432  (microRNA 432)


Additional Information