RGD Reference Report - Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma. - Rat Genome Database

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Comprehensive Analysis of Competitive Endogenous RNAs Network, Being Associated With Esophageal Squamous Cell Carcinoma and Its Emerging Role in Head and Neck Squamous Cell Carcinoma.

Authors: Yu, Donghu  Ruan, Xiaolan  Huang, Jingyu  Hu, Weidong  Chen, Chen  Xu, Yu  Hou, Jinxuan  Li, Sheng 
Citation: Yu D, etal., Front Oncol. 2020 Jan 21;9:1474. doi: 10.3389/fonc.2019.01474. eCollection 2019.
RGD ID: 150524298
Pubmed: PMID:32038997   (View Abstract at PubMed)
PMCID: PMC6985543   (View Article at PubMed Central)
DOI: DOI:10.3389/fonc.2019.01474   (Journal Full-text)

Esophageal squamous cell carcinoma (ESCC) is a common malignancy with poor prognosis and survival rate. To identify meaningful long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) modules related to the ESCC prognosis, The Cancer Genome Atlas-ESCC was downloaded and processed, and then, a weighted gene co-expression network analysis was applied to construct lncRNA co-expression networks, miRNA co-expression networks, and mRNA co-expression networks. Twenty-one hub lncRNAs, seven hub miRNAs, and eight hub mRNAs were clarified. Additionally, a competitive endogenous RNAs network was constructed, and the emerging role of the network involved in head and neck squamous cell carcinoma (HNSCC) was also analyzed using several webtools. The expression levels of eight hub genes (TBC1D2, ATP6V0E1, SPI1, RNASE6, C1QB, C1QC, CSF1R, and C1QA) were different between normal esophageal tissues and HNSCC tissues. The expression levels of TBC1D2 and ATP6V0E1 were related to the survival time of HNSCC. The competitive endogenous RNAs network might provide common mechanisms involving in ESCC and HNSCC. More importantly, useful clues were provided for clinical treatments of both diseases based on novel molecular advances.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
esophagus squamous cell carcinoma  HEP 150524298mRNA:decreased expression:esophagus squamous epithelium (human)RGD 

Objects Annotated

Genes (Homo sapiens)
CSF1R  (colony stimulating factor 1 receptor)


Additional Information