RGD Reference Report - The miR-93 promotes proliferation by directly targeting PDCD4 in hepatocellular carcinoma. - Rat Genome Database

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The miR-93 promotes proliferation by directly targeting PDCD4 in hepatocellular carcinoma.

Authors: Huang, H  Wang, X  Wang, C  Zhuo, L  Luo, S  Han, S 
Citation: Huang H, etal., Neoplasma. 2017;64(5):770-777. doi: 10.4149/neo_2017_516.
RGD ID: 15042900
Pubmed: PMID:28592130   (View Abstract at PubMed)
DOI: DOI:10.4149/neo_2017_516   (Journal Full-text)

Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. Although advances have made in treatment of HCC, the overall survival rate remains low and the molecular pathogenesis of HCC is still poorly understood. The purpose of this study was to explore the molecular pathogenesis of HCC. A total of 89 patients were involved in the study. MicroRNA-93 (miR-93) was aberrantly up-regulated in HCC tissues as determined by qRT-PCR. The high level of miR-93 was closely associated with larger tumor size (p < 0.05) and poor overall survival (p < 0.05). In in vitro and in vivo assays, we demonstrated that high miR-93 levels enhanced cell growth of HCC. The luciferase activity assay showed that PDCD4 was a direct target of miR-93 and its expression was down-regulated by miR-93. Re-expression of PDCD4 inversely correlated with the level of miR-93 and attenuated the miR-93-induced promotion of cell growth in HCC. Taken together, our data indicate that miR-93 may function as an oncogenic factor in HCC, and promotes HCC cell proliferation by targeting PDCD4.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma severityIEP 15042900; 15042900; 15042900miRNA:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir93  (microRNA 93)

Genes (Mus musculus)
Mir93  (microRNA 93)

Genes (Homo sapiens)
MIR93  (microRNA 93)


Additional Information