RGD Reference Report - Levels of soluble CD163 and severity of malaria in children in Ghana. - Rat Genome Database

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Levels of soluble CD163 and severity of malaria in children in Ghana.

Authors: Kusi, Kwadwo A  Gyan, Ben A  Goka, Bamenla Q  Dodoo, Daniel  Obeng-Adjei, George  Troye-Blomberg, Marita  Akanmori, Bartholomew D  Adjimani, Jonathan P 
Citation: Kusi KA, etal., Clin Vaccine Immunol. 2008 Sep;15(9):1456-60. doi: 10.1128/CVI.00506-07. Epub 2008 Jul 16.
RGD ID: 149735529
Pubmed: PMID:18632918   (View Abstract at PubMed)
PMCID: PMC2546665   (View Article at PubMed Central)
DOI: DOI:10.1128/CVI.00506-07   (Journal Full-text)

CD163 is an acute-phase-regulated monocyte/macrophage membrane receptor expressed late in inflammation. It is involved in the haptoglobin-mediated removal of free hemoglobin from plasma, has been identified as a naturally soluble plasma glycoprotein with potential anti-inflammatory properties, and is possibly linked to an individual's haptoglobin phenotype. High levels of soluble CD163 (sCD163) in a malaria episode may therefore downregulate inflammation and curb disease severity. In order to verify this, the relationships between sCD163 levels, malaria severity, and selected inflammatory mediators (tumor necrosis factor alpha [TNF-alpha], interleukin-6 [IL-6], and IL-10) were assessed by enzyme-linked immunosorbent assay using plasma samples obtained from pediatric malaria patients with uncomplicated malaria (UM [n = 38]), cerebral malaria (CM [n = 52]), and severe malarial anemia (SA [n = 55]) during two consecutive malaria transmission seasons (2002 and 2003). Median sCD163 levels were higher in UM (11.9 microg/ml) patients than in SA (7.7 microg/ml; P = 0.010) and CM (8.0 microg/ml; P = 0.031) patients. Levels of sCD163 were also higher in all patient groups than in a group of 81 age-matched healthy controls. The higher sCD163/TNF-alpha ratio in UM patients, coupled with the fact that sCD163 levels correlated with TNF-alpha levels in UM patients but not in CM and SA patients, suggests inflammatory dysregulation in the complicated cases. The study showed that sCD163 levels are elevated during acute malaria. High sCD163 levels in UM patients may be due to the induction of higher-level anti-inflammatory responses, enabling them to avoid disease complications. It is also possible that UM patients simply lost their CD163 receptors from macrophages in inflammatory sites while complicated-malaria patients still had their receptors attached to activated macrophages, reflecting ongoing and higher-level inflammation associated with complicated malaria.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
malaria severityIEP 149735529protein:altered expression:blood plasma (human)RGD 
malaria severityISOCD163 (Homo sapiens)149735529; 149735529protein:altered expression:blood plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd163  (CD163 molecule)

Genes (Mus musculus)
Cd163  (CD163 antigen)

Genes (Homo sapiens)
CD163  (CD163 molecule)


Additional Information