RGD Reference Report - GATA1 promotes colorectal cancer cell proliferation, migration and invasion via activating AKT signaling pathway. - Rat Genome Database

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GATA1 promotes colorectal cancer cell proliferation, migration and invasion via activating AKT signaling pathway.

Authors: Yu, Junhui  Liu, Ming  Liu, Hui  Zhou, Lei 
Citation: Yu J, etal., Mol Cell Biochem. 2019 Jul;457(1-2):191-199. doi: 10.1007/s11010-019-03523-w. Epub 2019 May 9.
RGD ID: 149735196
Pubmed: PMID:31069596   (View Abstract at PubMed)
DOI: DOI:10.1007/s11010-019-03523-w   (Journal Full-text)

GATA1, a member of the GATA transcription factor family, was reported to play a role in development and progression of erythroid cells and breast cancer cells. However, the role of GATA1 in colorectal cancer (CRC) is unknown. Here, we demonstrate that GATA1 was upregulated in CRC tissues compared with normal tissues, and predicted poor clinical outcome in CRC. Biological functional analyses showed that GATA1 knockdown decreased CRC cells proliferation, migration and invasion, and regulated the process of epithelial-mesenchymal transition (EMT). Moreover, silencing of GATA1 suppressed colorectal tumor growth in nude mice. Mechanistically, GATA1 overexpression significantly increased the activity of PI3K/AKT signaling pathway in CRC cells. These data provide insight into the important role of GATA1 in CRC progression and suggest that GATA1 is a potential therapeutic target for CRC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colon adenocarcinoma  IMP 149735196 RGD 
colon adenocarcinoma  ISOGATA1 (Homo sapiens)149735196; 149735196 RGD 
colorectal cancer disease_progressionIEP 149735196 RGD 
colorectal cancer disease_progressionISOGATA1 (Homo sapiens)149735196; 149735196 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gata1  (GATA binding protein 1)

Genes (Mus musculus)
Gata1  (GATA binding protein 1)

Genes (Homo sapiens)
GATA1  (GATA binding protein 1)


Additional Information