RGD Reference Report - Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat. - Rat Genome Database

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Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat.

Authors: Fraley, GS  Scarlett, JM  Shimada, I  Teklemichael, DN  Acohido, BV  Clifton, DK  Steiner, RA 
Citation: Fraley GS, etal., Diabetes 2004 May;53(5):1237-42.
RGD ID: 1304326
Pubmed: PMID:15111492   (View Abstract at PubMed)

Galanin-like peptide (GALP) is produced in a small population of neurons in the arcuate nucleus of the hypothalamus, and leptin stimulates the hypothalamic expression of GALP mRNA. Because insulin and leptin share common signaling pathways in the brain, we reasoned that GALP neurons might also be responsive to changes in circulating concentrations of insulin. To test this hypothesis, we first studied the effect of insulin deficiency on the expression of GALP by comparing levels of GALP mRNA between normal and diabetic animals. Streptozotocin-induced diabetes was associated with a significant reduction in the expression of GALP mRNA, which was reversed by treatment with either insulin or leptin. Second, we examined the effect of insulin administered directly into the brain on the expression of GALP mRNA in fasted rats. Hypothalamic levels of GALP mRNA were lower in animals after a 48-h fast, and central treatment with insulin reversed this effect. These results suggest that GALP neurons are direct targets for regulation by insulin and implicate these cells for a role in the metabolic and behavioral sequelae of type 1 diabetes.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to hormone  IEP 1304326leptinRGD 
response to insulin  IEP 1304326 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Galp  (galanin-like peptide)


Additional Information