RGD Reference Report - Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. - Rat Genome Database

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.

Authors: Masliah, E  Rockenstein, E  Veinbergs, I  Mallory, M  Hashimoto, M  Takeda, A  Sagara, Y  Sisk, A  Mucke, L 
Citation: Masliah E, etal., Science 2000 Feb 18;287(5456):1265-9.
RGD ID: 1302527
Pubmed: PMID:10678833   (View Abstract at PubMed)

To elucidate the role of the synaptic protein alpha-synuclein in neurodegenerative disorders, transgenic mice expressing wild-type human alpha-synuclein were generated. Neuronal expression of human alpha-synuclein resulted in progressive accumulation of alpha-synuclein-and ubiquitin-immunoreactive inclusions in neurons in the neocortex, hippocampus, and substantia nigra. Ultrastructural analysis revealed both electron-dense intranuclear deposits and cytoplasmic inclusions. These alterations were associated with loss of dopaminergic terminals in the basal ganglia and with motor impairments. These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinson's disease  IMP 1302527human gene in a mouse modelRGD 
Parkinson's disease  ISOSNCA (Homo sapiens)1302527; 1302527human gene in a mouse modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
Snca  (synuclein alpha)

Genes (Mus musculus)
Snca  (synuclein, alpha)

Genes (Homo sapiens)
SNCA  (synuclein alpha)


Additional Information