RGD Reference Report - High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices. - Rat Genome Database

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High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices.

Authors: Matsuo, H  Kanai, Y  Tokunaga, M  Nakata, T  Chairoungdua, A  Ishimine, H  Tsukada, S  Ooigawa, H  Nawashiro, H  Kobayashi, Y  Fukuda, J  Endou, H 
Citation: Matsuo H, etal., Neurosci Lett 2004 Mar 25;358(2):123-6.
RGD ID: 1302264
Pubmed: PMID:15026164   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2004.01.014   (Journal Full-text)

System asc transporter Asc-1, expressed in the brain, transports D- and L-serine with high affinity. To determine the localization of Asc-1 in the rat brain, we isolated a cDNA for the rat orthologue of Asc-1. The encoded protein designated as rAsc-1 (rat Asc-1) exhibited 98% sequence identity to mouse Asc-1 (mAsc-1). Based on amino acid sequences of rAsc-1 and mAsc-1, two polyclonal antibodies against Asc-1 were generated and used for the immunohistochemical analysis on the cerebral and cerebellar cortices of rats and mice. Asc-1 immunoreactivity was detected in neurons, including cerebellar Purkinje neurons and pyramidal neurons in the neocortex and hippocampus. It was clearly localized in dendrites as well as somata. The localization of Asc-1 in brain suggests the significant contribution of Asc-1 to amino acid mobilization in brains including the synaptic clearance of D-serine and the neuronal uptake of L-serine that is essential for survival and dendrite growth of Purkinje neurons in particular.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
apical dendrite  IDA 1302264 RGD 
neuronal cell body  IDA 1302264 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc7a10  (solute carrier family 7 member 10)


Additional Information