RGD Reference Report - [Neurogenesis in the dentate gyrus of the hippocampus in a rat model of intracerebral hemorrhage]. - Rat Genome Database

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[Neurogenesis in the dentate gyrus of the hippocampus in a rat model of intracerebral hemorrhage].

Authors: Xu, Xi  Zheng, Jianyun  Zhang, Junfeng  Chne, Xinlin  Yang, PengBo  Liu, Jianxin  Liu, Yong 
Citation: Xu X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1437-41.
RGD ID: 12904766
Pubmed: PMID:24144742   (View Abstract at PubMed)


OBJECTIVE: To investigate whether intracerebral hemorrhage (ICH) can promote neurogenesis in the dentate gyrus (DG) of rat hippocampus.
METHODS: Western blot analysis, immunohistochemical staining, and immunofluorescent double labeling combined with confocal microscope were used to detect neurogenesis in the DG of the hippocampus in rats after ICH.
RESULTS: The expression of DCX protein in the ipsilateral DG of the hippocampus was enhanced in the rats 1 day after ICH (0.202±0.062) as compared with that in normal rats (0.127±0.088), reaching the peak level at 14 days (0.771±0.108, P<0.01) and beginning to decrease at 28 days (0.582±0.121, P<0.01). Meanwhile, DCX-positive cells and BrdU-positive cells, and DCX/BrdU double-labeled cells were detected in the DG of the hippocampus. Compared with those in the control group, BrdU/NeuN double-labeled cells were markedly increased in the granular cell layer of the DG at 28 days after ICH (1.808±1.020 vs 5.654±1.671, P<0.01).
CONCLUSION: ICH can promote neurogenesis in the DG of rat hippocampus.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cerebral Hemorrhage  ISODcx (Rattus norvegicus)12904766; 12904766protein:increased expression:dentate gyrusRGD 
Cerebral Hemorrhage  IEP 12904766protein:increased expression:dentate gyrusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Dcx  (doublecortin)

Genes (Mus musculus)
Dcx  (doublecortin)

Genes (Homo sapiens)
DCX  (doublecortin)


Additional Information