RGD Reference Report - Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal Influenza Viral Infection. - Rat Genome Database

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Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal Influenza Viral Infection.

Authors: Jung, Hi Eun  Oh, Ji Eun  Lee, Heung Kyu 
Citation: Jung HE, etal., Viruses. 2019 Jan 28;11(2). pii: v11020109. doi: 10.3390/v11020109.
RGD ID: 126777671
Pubmed: PMID:30696001   (View Abstract at PubMed)
PMCID: PMC6409533   (View Article at PubMed Central)
DOI: DOI:10.3390/v11020109   (Journal Full-text)

Dynamin-like GTPase myxovirus resistance protein 1 (Mx1) is an intracellular anti-viral protein following the activation of type I and type III interferon signaling. Mx1 inhibits viral replication by blocking the transcription of viral RNA, and a deficiency in this protein enhances susceptibility to influenza infection. Thus, Mx1 could be another efficient target of anti-influenza therapy. To test our hypothesis, we fused poly-arginine cell-penetrating peptides to the C terminus of Mx1 (Mx1-9R) and examined the anti-viral activity of Mx1-9R in vitro and in vivo. Madin-Darby Canine Kidney epithelial cells internalized the Mx1-9R within 12 h. Pre-exposure Mx1-9R treatment inhibited viral replication and viral RNA expression in infected cells. Further, intranasal administration of Mx1-9R improved the survival of mice infected with the PR8 influenza viral strain. These data support the consideration of Mx1-9R as a novel therapeutic agent against mucosal influenza virus infection.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
influenza A amelioratesISOMx1 (Mus musculus)126777671; 126777671fused with PTD 9-arginine sequenceRGD 
influenza A amelioratesIMP 126777671fused with PTD 9-arginine sequenceRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mx1  (MX dynamin like GTPase 1)

Genes (Mus musculus)
Mx1  (MX dynamin-like GTPase 1)

Genes (Homo sapiens)
MX1  (MX dynamin like GTPase 1)


Additional Information