RGD Reference Report - Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. - Rat Genome Database

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Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.

Authors: Bellocchio, E E  Reimer, R J  Fremeau, R T  Edwards, R H 
Citation: Bellocchio EE, etal., Science. 2000 Aug 11;289(5481):957-60.
RGD ID: 12050146
Pubmed: PMID:10938000   (View Abstract at PubMed)

Previous work has identified two families of proteins that transport classical neurotransmitters into synaptic vesicles, but the protein responsible for vesicular transport of the principal excitatory transmitter glutamate has remained unknown. We demonstrate that a protein that is unrelated to any known neurotransmitter transporters and that was previously suggested to mediate the Na(+)-dependent uptake of inorganic phosphate across the plasma membrane transports glutamate into synaptic vesicles. In addition, we show that this vesicular glutamate transporter, VGLUT1, exhibits a conductance for chloride that is blocked by glutamate.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chloride transport involved_inIDA 12050146PMID:10938000UniProt 
L-glutamate transmembrane transport involved_inIDA 12050146PMID:10938000UniProt 
neurotransmitter loading into synaptic vesicle involved_inIDA 12050146PMID:10938000SynGO 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chloride channel activity enablesIDA 12050146PMID:10938000UniProt 
L-glutamate uniporter activity enablesIDA 12050146PMID:10938000UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Slc17a7  (solute carrier family 17 member 7)


Additional Information