RGD Reference Report - WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population. - Rat Genome Database

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WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.

Authors: Akdi, A  Gimenez, EM  Garcia-Quispes, W  Pastor, S  Castell, J  Biarnes, J  Marcos, R  Velazquez, A 
Citation: Akdi A, etal., Thyroid. 2010 Jul;20(7):803-9. doi: 10.1089/thy.2010.0072.
RGD ID: 11041898
Pubmed: PMID:20578902   (View Abstract at PubMed)
DOI: DOI:10.1089/thy.2010.0072   (Journal Full-text)

BACKGROUND: A member of the genes encoding WD-repeat proteins, the WDR3 gene, maps in the 1p12 region. This region was shown to be associated with thyroid cancer susceptibility in a previous work. In this study we aim to evaluate the contribution of WDR3 to thyroid cancer risk. METHODS: A case-control association study was performed in a total of 402 patients and 479 control subjects from a Spanish population. In the initial phase of the study, 10 single-nucleotide polymorphisms covering the WDR3 region were genotyped in a small group (157 patients and 118 control subjects); next, three of the initial single-nucleotide polymorphisms were further genotyped in the overall population. In addition, WDR3 expression was investigated in 10 thyroid cancer cell lines by RT-PCR and Western blot. RESULTS: Haplotype analysis revealed that combination of certain WDR3 variants, such as haplotype CAT, increases the risk of thyroid cancer (odds ratio = 1.85, 95% confidence interval = 0.97-3.55, p = 0.063). Further, both messenger RNA transcription and protein expression of WDR3 were altered in human thyroid cancer cells. CONCLUSION: These results indicate for the first time that WDR3 is a risk factor to thyroid cancer, suggesting its implication in the etiology of thyroid cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
thyroid gland papillary carcinoma susceptibilityIAGP 11041898DNA:snps more ...RGD 
thyroid gland papillary carcinoma susceptibilityISOWDR3 (Homo sapiens)11041898; 11041898DNA:snps more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Wdr3  (WD repeat domain 3)

Genes (Mus musculus)
Wdr3  (WD repeat domain 3)

Genes (Homo sapiens)
WDR3  (WD repeat domain 3)


Additional Information