RGD Reference Report - Single nucleotide polymorphisms of microRNA processing machinery genes and outcome of hepatocellular carcinoma. - Rat Genome Database

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Single nucleotide polymorphisms of microRNA processing machinery genes and outcome of hepatocellular carcinoma.

Authors: Liu, S  An, J  Lin, J  Liu, Y  Bao, L  Zhang, W  Zhao, JJ 
Citation: Liu S, etal., PLoS One. 2014 Mar 27;9(3):e92791. doi: 10.1371/journal.pone.0092791. eCollection 2014.
RGD ID: 11041737
Pubmed: PMID:24676133   (View Abstract at PubMed)
PMCID: PMC3968016   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0092791   (Journal Full-text)

MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) can affect cancer development, treatment efficacy and patients prognosis. We examined 6 miR-SNPs in miRNA processing machinery genes including exportin 5 (XPO5) (rs11077), Ran-GTPase (RAN) (rs14035), Dicer (rs3742330), Trinucleotide Repeat Containing 6B (TNRC6B) (rs9623117), GEMIN3 (rs197412), GEMIN4 (rs2740348) in 108 surgically resected HCC patients and evaluated the impact of these miR-SNPs on HCC outcome. Among the 6 SNPs, only the A/A genotype of rs11077 located in XPO5 3'UTR was identified to associated independently with worse survival in HCC patients by multivariate analysis with relative risk, 0.395; 95% CI, 0.167-0.933; p = 0.034. This is the first study reporting that polymorphisms related to miRSNPs have prognostic value in hepatocellular carcinoma and identify the A/A genotype of rs11077 SNP site located in XPO5 3'UTR can help to predict worse prognosis in patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma severityIAGP 11041737DNA:snp and haplotype:3' utr:c.*659A>C (rs11077) (human)RGD 
hepatocellular carcinoma severityISOXPO5 (Homo sapiens)11041737; 11041737DNA:snp and haplotype:3' utr:c.*659A>C (rs11077) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Xpo5  (exportin 5)

Genes (Mus musculus)
Xpo5  (exportin 5)

Genes (Homo sapiens)
XPO5  (exportin 5)


Additional Information