RGD Reference Report - Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. - Rat Genome Database

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Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.

Authors: Wei, Z  Peddibhotla, S  Lin, H  Fang, X  Li, M  Rosen, JM  Zhang, P 
Citation: Wei Z, etal., Mol Cell Biol. 2011 Apr;31(7):1470-7. doi: 10.1128/MCB.01330-10. Epub 2011 Jan 24.
RGD ID: 10059338
Pubmed: PMID:21262768   (View Abstract at PubMed)
PMCID: PMC3135283   (View Article at PubMed Central)
DOI: DOI:10.1128/MCB.01330-10   (Journal Full-text)

The Cdc14 dual-specificity phosphatase plays a key role in the mitotic exit of budding yeast cells. Mammals have two homologues, Cdc14a and Cdc14b. Unlike the yeast counterpart, neither Cdc14a nor Cdc14b seems to be essential for mitotic exit. To determine the physiological function of Cdc14b, we generated mice deficient in the phosphatase. The mutant mice were viable and did not display overt abnormalities. However, these mice developed signs of aging at much younger ages than the wild-type mice. At the cellular level, the Cdc14b-deficient mouse embryonic fibroblasts (MEFs) grew more slowly than the controls at later passages as a result of increased rates of senescence. Consistent with these premature-aging phenotypes, Cdc14b-deficient cells accumulated more endogenous DNA damage than the wild-type cells, and more Cdc14b-deficient MEFs entered senescence than control MEFs in response to exogenous DNA damage. However, no deficiencies in DNA damage checkpoint response were detected in Cdc14b mutant cells, suggesting that the function of Cdc14b is required for efficient DNA damage repair.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Premature Aging  ISOCdc14b (Mus musculus)10059338; 10059338 RGD 
Premature Aging  IMP 10059338 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdc14b  (cell division cycle 14B)

Genes (Mus musculus)
Cdc14b  (CDC14 cell division cycle 14B)

Genes (Homo sapiens)
CDC14B  (cell division cycle 14B)


Additional Information