RGD Reference Report - Cell-cycle regulated expression of Rap1 in regenerating liver. - Rat Genome Database

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Cell-cycle regulated expression of Rap1 in regenerating liver.

Authors: Cruise, JL  Rafferty, MP  Riehle, MM 
Citation: Cruise JL, etal., Biochem Biophys Res Commun. 1997 Jan 23;230(3):578-81.
RGD ID: 10003155
Pubmed: PMID:9015365   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1996.6003   (Journal Full-text)

Rap1 proteins are capable of competing with Ras p21 for binding to effectors, and of antagonizing some Ras-induced effects, but their participation in normal growth regulation has not been established. The level of Rap1 protein and the expression of the rap1A gene were examined by immunoblotting and Northern analysis during the regenerative growth response in rat liver following partial hepatectomy. Protein and mRNA were significantly down-regulated prior to and during the onset of DNA synthesis. The timing of this effect is consistent with a model in which expression of Rap1 is turned off or down to allow the initiation of proliferation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
liver regeneration  IEP 10003155 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rap1a  (RAP1A, member of RAS oncogene family)


Additional Information