Mt-nd1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1) - Rat Genome Database

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Gene: Mt-nd1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1) Rattus norvegicus
Analyze
Symbol: Mt-nd1
Name: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
RGD ID: 620555
Description: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Involved in several processes, including response to hydroperoxide; response to hypoxia; and response to xenobiotic stimulus. Located in dendrite and neuronal cell body. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Orthologous to human MT-ND1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamiprid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mitochondrially encoded NADH dehydrogenase 1; NADH dehydrogenase 1, mitochondrial; NADH dehydrogenase subunit 1; Nd1
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT2,740 - 3,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT2,740 - 3,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT2,740 - 3,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT2,740 - 3,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT2,740 - 3,694 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT2,740 - 3,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT2,740 - 3,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT2,740 - 3,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT2,740 - 3,694 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-deoxy-D-glucose  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-phenylbutyric acid  (ISO)
acetamiprid  (EXP)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
Asimicin  (ISO)
atrazine  (EXP,ISO)
berberine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbidopa  (ISO)
CCCP  (ISO)
chloramphenicol  (ISO)
cisplatin  (EXP,ISO)
citraconic acid  (ISO)
clofibrate  (EXP)
clorgyline  (ISO)
crotonaldehyde  (EXP)
desferrioxamine B  (ISO)
dimethyl fumarate  (ISO)
dioxygen  (EXP)
diquat  (ISO)
doxorubicin  (EXP,ISO)
enniatin  (ISO)
ethidium  (ISO)
fenthion  (ISO)
flutamide  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
gentamycin  (EXP)
graphene oxide  (ISO)
herbicide  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (EXP)
melittin  (ISO)
methcathinone  (ISO)
methidathion  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
picloram  (ISO)
potassium dichromate  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sarpogrelate  (ISO)
sodium arsenite  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichlopyr  (ISO)
Triptolide  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Leber's hereditary optic neuropathy: heteroplasmy is likely to be significant in the expression of LHON in families with the 3460 ND1 mutation. Black GC, etal., Br J Ophthalmol. 1996 Oct;80(10):915-7.
2. Variations in mitochondrial DNA copy numbers in MS brains. Blokhin A, etal., J Mol Neurosci. 2008 Jul;35(3):283-7. Epub 2008 Jun 20.
3. Novel mtDNA mutations and oxidative phosphorylation dysfunction in Russian LHON families. Brown MD, etal., Hum Genet. 2001 Jul;109(1):33-9.
4. The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Canter JA, etal., Pharmacogenomics J. 2008 Feb;8(1):71-7. Epub 2007 Aug 7.
5. Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes. Da Sylva TR, etal., Arthritis Res Ther. 2005;7(4):R844-51. Epub 2005 Apr 28.
6. Generation of T cells with lytic specificity for atypical antigens. I. A mitochondrial antigen in the rat. Davies JD, etal., J Exp Med 1991 Apr 1;173(4):823-32.
7. Mitochondrial variant G4132A is associated with familial non-arteritic anterior ischemic optic neuropathy in one large pedigree. Fingert JH, etal., Ophthalmic Genet. 2007 Mar;28(1):1-7.
8. The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates. Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
9. Nucleotide sequence of rat mitochondrial NADH dehydrogenase subunit 1. GTG, a new initiator codon in vertebrate mitochondrial genome. Gadaleta G, etal., Nucleic Acids Res 1988 Jul 11;16(13):6233.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Mitochondrial genome polymorphisms associated with type-2 diabetes or obesity. Guo LJ, etal., Mitochondrion. 2005 Feb;5(1):15-33.
12. A novel mitochondrial heteroplasmic C13806A point mutation associated with Iranian Friedreich's ataxia. Heidari MM, etal., Cell Mol Neurobiol. 2009 Mar;29(2):225-33. Epub 2008 Sep 19.
13. Analysis of the mitochondrial DNA from patients with Wolfram (DIDMOAD) syndrome. Hofmann S, etal., Mol Cell Biochem. 1997 Sep;174(1-2):209-13.
14. Leber hereditary optic neuropathy: involvement of the mitochondrial ND1 gene and evidence for an intragenic suppressor mutation. Howell N, etal., Am J Hum Genet. 1991 May;48(5):935-42.
15. Association of mitochondrial allele 4216C with increased risk for sepsis-related organ dysfunction and shock after burn injury. Huebinger RM, etal., Shock. 2010 Jan;33(1):19-23.
16. A new mtDNA mutation associated with Leber hereditary optic neuroretinopathy. Huoponen K, etal., Am J Hum Genet. 1991 Jun;48(6):1147-53.
17. Effect of changes in food consistency on NADH-ubiquinone oxidoreductase activity and levels of mRNA for ND1, 51kDa, 75kDa and myosin heavy chain isoforms in two different portions of rat masseter muscle. Ide Y and Sato I, Okajimas Folia Anat Jpn. 2006 Aug;83(2):61-71.
18. Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. Jove M, etal., J Lipid Res. 2004 Jan;45(1):113-23. Epub 2003 Oct 16.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Mitochondrial DNA C4171A/ND1 is a novel primary causative mutation of Leber's hereditary optic neuropathy with a good prognosis. Kim JY, etal., Ann Neurol. 2002 May;51(5):630-4.
21. Metabolic enzyme expression in dopaminergic neurons in Parkinson's disease: an in situ hybridization study. Kingsbury AE, etal., Ann Neurol. 2001 Aug;50(2):142-9.
22. Mutations of the mitochondrial ND1 gene as a cause of MELAS. Kirby DM, etal., J Med Genet. 2004 Oct;41(10):784-9.
23. Mitochondrial ND1 sequence analysis and association of the T4216C mutation with Parkinson's disease. Kirchner SC, etal., Neurotoxicology. 2000 Aug;21(4):441-5.
24. Identification of novel mitochondrial mutations in Leber's hereditary optic neuropathy. Kumar M, etal., Mol Vis. 2010 Apr 30;16:782-92.
25. Leber's hereditary optic neuropathy is associated with mitochondrial ND1 T3394C mutation. Liang M, etal., Biochem Biophys Res Commun. 2009 Jun 5;383(3):286-92. Epub 2009 Mar 24.
26. Novel mutations of mitochondrial DNA associated with type 2 diabetes in Chinese Han population. Liao WQ, etal., Tohoku J Exp Med. 2008 Aug;215(4):377-84.
27. The mitochondrial ND1 T3308C mutation in a Chinese family with the secondary hypertension. Liu Y, etal., Biochem Biophys Res Commun. 2008 Mar 28;368(1):18-22. Epub 2008 Jan 14.
28. Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels. Lymperopoulos A, etal., J Am Coll Cardiol. 2011 Jan 18;57(3):356-65.
29. Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage. Manczak M, etal., Neuromolecular Med. 2004;5(2):147-62.
30. Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder. Munakata K, etal., Genomics. 2004 Dec;84(6):1041-50.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Immunocytochemical characterization of the mitochondrially encoded ND1 subunit of complex I (NADH : ubiquinone oxidoreductase) in rat brain. Pettus EH, etal., J Neurochem. 2000 Jul;75(1):383-92.
33. Mitochondrial DNA-Associated Leigh Syndrome and NARP PubMed Book Article
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Comprehensive gene review and curation RGD comprehensive gene curation
38. Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Suliman HB, etal., Free Radic Biol Med. 2002 Feb 1;32(3):246-56.
39. Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease. Swerdlow RH, etal., J Neurol Sci. 2006 Sep 25;247(2):224-30. Epub 2006 Jun 19.
40. Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Tendi EA, etal., Neurochem Res. 2002 Apr;27(4):319-23.
41. Increased expression of mitochondrial respiratory enzymes in the brain of activated epilepsy-prone El mice. Yamada Y and Nakano K, Brain Res Mol Brain Res. 1999 Nov 10;73(1-2):186-8.
42. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
43. Relationship between mutations of mitochondrial DNA ND1 gene and type 2 diabetes. Yu P, etal., Chin Med J (Engl). 2004 Jul;117(7):985-9.
44. Leber's hereditary optic neuropathy is associated with the T3866C mutation in mitochondrial ND1 gene in three Han Chinese Families. Zhou X, etal., Invest Ophthalmol Vis Sci. 2012 Jul 9;53(8):4586-94. doi: 10.1167/iovs.11-9109.
Additional References at PubMed
PMID:26298201   PMID:26316108   PMID:31505169  


Genomics

Comparative Map Data
Mt-nd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT2,740 - 3,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT2,740 - 3,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT2,740 - 3,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT2,740 - 3,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT2,740 - 3,694 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT2,740 - 3,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT2,740 - 3,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT2,740 - 3,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT2,740 - 3,694 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI
MT-ND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38MT3,307 - 4,262 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblMT3,307 - 4,262 (+)EnsemblGRCh38hg38GRCh38
GRCh37MT3,307 - 4,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36MT3,308 - 4,264 (+)NCBINCBI36Build 36hg18NCBI36
mt-Nd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39MT2,751 - 3,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblMT2,751 - 3,707 (+)EnsemblGRCm39 Ensembl
GRCm38MT2,751 - 3,707 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblMT2,751 - 3,707 (+)EnsemblGRCm38mm10GRCm38
MGSCv37MT2,751 - 3,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MT-ND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1MT2,747 - 3,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblMT2,747 - 3,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaMT2,747 - 3,702 (+)NCBIDog10K_Boxer_Tasha
MT-ND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblMT3,922 - 4,876 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1MT3,922 - 4,876 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2MT3,922 - 4,876 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mt-nd1
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:65
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000047550
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH136367  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0MT2,338 - 2,532UniSTSRnor5.0
RGSC_v3.4MT2,338 - 2,532UniSTSRGSC3.4
PMC312657P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0MT2,276 - 2,749UniSTSRnor5.0
RGSC_v3.4MT2,276 - 2,749UniSTSRGSC3.4
PMC316374P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0MT901 - 1,615UniSTSRnor5.0
RGSC_v3.4MT901 - 1,615UniSTSRGSC3.4
PMC31832P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0MT2,239 - 2,376UniSTSRnor5.0
RGSC_v3.4MT2,239 - 2,376UniSTSRGSC3.4


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 35 33 33 3 33 3 66 27 32 3
Medium 8 24 8 16 8 8 8 8 8 9 8 8
Low
Below cutoff

Sequence

Nucleotide Sequences
GenBank Nucleotide AY172581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY769440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU104717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU104724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM152027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM152028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX105355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX105356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF011917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ530565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ939360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ939361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM577635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM657952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM657953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP099715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP100657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP233827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP233832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP241960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP244683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000047550   ⟹   ENSRNOP00000049172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblMT2,740 - 3,694 (+)Ensembl
Rnor_6.0 EnsemblMT2,740 - 3,694 (+)Ensembl
Protein Sequences
Protein RefSeqs YP_665629 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN77594 (Get FASTA)   NCBI Sequence Viewer  
  AAV31039 (Get FASTA)   NCBI Sequence Viewer  
  ABG11766 (Get FASTA)   NCBI Sequence Viewer  
  ABG11773 (Get FASTA)   NCBI Sequence Viewer  
  ABG11792 (Get FASTA)   NCBI Sequence Viewer  
  ABG11806 (Get FASTA)   NCBI Sequence Viewer  
  ABG11818 (Get FASTA)   NCBI Sequence Viewer  
  ABG11831 (Get FASTA)   NCBI Sequence Viewer  
  ABG11844 (Get FASTA)   NCBI Sequence Viewer  
  ABG11857 (Get FASTA)   NCBI Sequence Viewer  
  ABG11870 (Get FASTA)   NCBI Sequence Viewer  
  ABG11883 (Get FASTA)   NCBI Sequence Viewer  
  ABV22513 (Get FASTA)   NCBI Sequence Viewer  
  ABV22520 (Get FASTA)   NCBI Sequence Viewer  
  ACP50280 (Get FASTA)   NCBI Sequence Viewer  
  ACP50293 (Get FASTA)   NCBI Sequence Viewer  
  ACP50306 (Get FASTA)   NCBI Sequence Viewer  
  ACP50319 (Get FASTA)   NCBI Sequence Viewer  
  ACP50332 (Get FASTA)   NCBI Sequence Viewer  
  ACP50345 (Get FASTA)   NCBI Sequence Viewer  
  ACP50358 (Get FASTA)   NCBI Sequence Viewer  
  ACP50371 (Get FASTA)   NCBI Sequence Viewer  
  ACP50384 (Get FASTA)   NCBI Sequence Viewer  
  ACP50410 (Get FASTA)   NCBI Sequence Viewer  
  ACP50423 (Get FASTA)   NCBI Sequence Viewer  
  ACP50436 (Get FASTA)   NCBI Sequence Viewer  
  ADE05939 (Get FASTA)   NCBI Sequence Viewer  
  ADE05952 (Get FASTA)   NCBI Sequence Viewer  
  ADE05965 (Get FASTA)   NCBI Sequence Viewer  
  ADE05978 (Get FASTA)   NCBI Sequence Viewer  
  ADG85621 (Get FASTA)   NCBI Sequence Viewer  
  ADG85634 (Get FASTA)   NCBI Sequence Viewer  
  AFN06278 (Get FASTA)   NCBI Sequence Viewer  
  AFN06291 (Get FASTA)   NCBI Sequence Viewer  
  AGS12821 (Get FASTA)   NCBI Sequence Viewer  
  AHZ60966 (Get FASTA)   NCBI Sequence Viewer  
  AIU45575 (Get FASTA)   NCBI Sequence Viewer  
  AIU45588 (Get FASTA)   NCBI Sequence Viewer  
  AIU45601 (Get FASTA)   NCBI Sequence Viewer  
  AIU45614 (Get FASTA)   NCBI Sequence Viewer  
  AIU45627 (Get FASTA)   NCBI Sequence Viewer  
  AIU45640 (Get FASTA)   NCBI Sequence Viewer  
  AIU45653 (Get FASTA)   NCBI Sequence Viewer  
  AIU45666 (Get FASTA)   NCBI Sequence Viewer  
  AIU45679 (Get FASTA)   NCBI Sequence Viewer  
  AIU45692 (Get FASTA)   NCBI Sequence Viewer  
  AIU45705 (Get FASTA)   NCBI Sequence Viewer  
  AIY51542 (Get FASTA)   NCBI Sequence Viewer  
  AIZ58322 (Get FASTA)   NCBI Sequence Viewer  
  AIZ58335 (Get FASTA)   NCBI Sequence Viewer  
  AJD83432 (Get FASTA)   NCBI Sequence Viewer  
  AJE26530 (Get FASTA)   NCBI Sequence Viewer  
  AJE61352 (Get FASTA)   NCBI Sequence Viewer  
  AJE61365 (Get FASTA)   NCBI Sequence Viewer  
  AJE61378 (Get FASTA)   NCBI Sequence Viewer  
  AJE61391 (Get FASTA)   NCBI Sequence Viewer  
  AJE61404 (Get FASTA)   NCBI Sequence Viewer  
  AJJ48377 (Get FASTA)   NCBI Sequence Viewer  
  AJJ48749 (Get FASTA)   NCBI Sequence Viewer  
  AJK29981 (Get FASTA)   NCBI Sequence Viewer  
  AJK30557 (Get FASTA)   NCBI Sequence Viewer  
  AJO99993 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049172
  ENSRNOP00000049172.4
GenBank Protein P03889 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000049172   ⟸   ENSRNOT00000047550

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P03889-F1-model_v2 AlphaFold P03889 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620555 AgrOrtholog
BioCyc Gene G2FUF-32 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
Ensembl Genes ENSRNOG00000030644 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047550.4 UniProtKB/Swiss-Prot
InterPro NADH_UbQ_OxRdtase_su1/FPO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADH_UbQ_OxRdtase_su1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26193 ENTREZGENE
PANTHER NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11432 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NADHdh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt-nd1 PhenoGen
PROSITE COMPLEX1_ND1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COMPLEX1_ND1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030644 RatGTEx
UniProt D2E6L7 ENTREZGENE, UniProtKB/TrEMBL
  H9KVF8 ENTREZGENE
  NU1M_RAT UniProtKB/Swiss-Prot
  O63197 ENTREZGENE
  P03889 ENTREZGENE
  Q37653 ENTREZGENE
  Q8HID1 ENTREZGENE, UniProtKB/TrEMBL
  Q8SEZ8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary H9KVF8 UniProtKB/TrEMBL
  O63197 UniProtKB/Swiss-Prot
  Q37653 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-17 Mt-nd1  mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1  Mt-nd1  mitochondrially encoded NADH dehydrogenase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Mt-nd1  mitochondrially encoded NADH dehydrogenase 1  mt-Nd1  NADH dehydrogenase 1, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 mt-Nd1  NADH dehydrogenase 1, mitochondrial      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 mt-Nd1  NADH dehydrogenase 1, mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL