RGD Reference Report - The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates. - Rat Genome Database

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The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates.

Authors: Gadaleta, G  Pepe, G  De Candia, G  Quagliariello, C  Sbisa, E  Saccone, C 
Citation: Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
RGD ID: 631900
Pubmed: PMID:2504926   (View Abstract at PubMed)

This paper reports the nucleotide sequence of rat mitochondrial DNA, only the fourth mammalian mitochondrial genome to be completely sequenced. Extensive comparative studies performed with similar genomes from other organisms revealed a number of interesting features. 1) Messenger RNA genes: the codon strategy is mainly dictated by the base compositional constraints of the corresponding codogenic DNA strand. The usage of the initiation and termination codons follows well-established rules. In general the canonical initiator, ATG, and terminators, TAA and TAG (in rat, only TAA), are always present when there is gene overlapping or when the mRNAs possess untranslated nucleotides at the 5' or 3' ends. 2) Transfer RNA genes: a number of features suggest the peculiar evolutionary behavior of this class of genes and confirm their role in the duplication and rearrangement processes that took place in the evolution of the animal mitochondrial genome. 3) Ribosomal RNA genes: accurate sequence analysis revealed a number of significant examples of complementarity between ribosomal and messenger RNAs. This suggests that they might play an important role in the regulation of mitochondrial translation and transcription mechanisms. The properties revealed by our work shed new light on the organization and evolution of the vertebrate mitochondrial genome and more importantly open up the way to clearly aimed experimental studies of the regulatory mechanisms in mitochondria.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
translational elongation  TAS 631900 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
triplet codon-amino acid adaptor activity  TAS 631900 RGD 

Objects Annotated

Genes (Rattus norvegicus)
mt-Th  (mitochondrially encoded tRNA histidine)

Objects referenced in this article
Gene Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 Rattus norvegicus
Gene Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 Rattus norvegicus
Gene Mt-co1 mitochondrially encoded cytochrome c oxidase I Rattus norvegicus
Gene Mt-co2 mitochondrially encoded cytochrome c oxidase II Rattus norvegicus
Gene Mt-co3 mitochondrially encoded cytochrome c oxidase III Rattus norvegicus
Gene Mt-cyb mitochondrially encoded cytochrome b Rattus norvegicus
Gene Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 Rattus norvegicus
Gene Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 Rattus norvegicus
Gene Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 Rattus norvegicus
Gene Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 Rattus norvegicus
Gene Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L Rattus norvegicus
Gene Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 Rattus norvegicus
Gene Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 Rattus norvegicus
Gene mt-Tc mitochondrially encoded tRNA cysteine Rattus norvegicus
Gene mt-Td mitochondrially encoded tRNA aspartic acid Rattus norvegicus
Gene mt-Tf mitochondrially encoded tRNA phenylalanine Rattus norvegicus
Gene mt-Ti mitochondrially encoded tRNA isoleucine Rattus norvegicus
Gene mt-Tm mitochondrially encoded tRNA methionine Rattus norvegicus
Gene mt-Tr mitochondrially encoded tRNA arginine Rattus norvegicus
Gene mt-Ts2 mitochondrially encoded tRNA serine 2 Rattus norvegicus
Gene mt-Tw mitochondrially encoded tRNA tryptophan Rattus norvegicus

Additional Information