Coprs (coordinator of PRMT5 and differentiation stimulator) - Rat Genome Database

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Gene: Coprs (coordinator of PRMT5 and differentiation stimulator) Rattus norvegicus
Analyze
Symbol: Coprs
Name: coordinator of PRMT5 and differentiation stimulator
RGD ID: 1565675
Description: Predicted to enable histone binding activity. Predicted to be involved in chromatin remodeling and muscle organ development. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human COPRS (coordinator of PRMT5 and differentiation stimulator); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cooperator of PRMT5; coordinator of PRMT5, differentiation stimulator; Copr5; LOC290925; RGD1565675; similar to RIKEN cDNA 2410022L05
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,423,426 - 82,428,821 (+)NCBIGRCr8
mRatBN7.21675,721,264 - 75,726,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,720,061 - 75,726,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,001,741 - 81,006,842 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,455,271 - 84,460,372 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01679,705,058 - 79,710,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01680,826,681 - 80,831,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1680,826,681 - 80,831,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,390,902 - 80,396,012 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,557,030 - 80,562,140 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1673,530,152 - 73,535,262 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18404153   PMID:22193545   PMID:27869233  


Genomics

Comparative Map Data
Coprs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,423,426 - 82,428,821 (+)NCBIGRCr8
mRatBN7.21675,721,264 - 75,726,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,720,061 - 75,726,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,001,741 - 81,006,842 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,455,271 - 84,460,372 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01679,705,058 - 79,710,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01680,826,681 - 80,831,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1680,826,681 - 80,831,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,390,902 - 80,396,012 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,557,030 - 80,562,140 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1673,530,152 - 73,535,262 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
COPRS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381731,851,871 - 31,859,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1731,851,871 - 31,859,291 (-)EnsemblGRCh38hg38GRCh38
GRCh371730,178,890 - 30,186,263 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361727,203,009 - 27,210,369 (-)NCBINCBI36Build 36hg18NCBI36
Celera1727,098,524 - 27,105,966 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1726,389,213 - 26,396,656 (-)NCBIHuRef
CHM1_11730,241,346 - 30,248,795 (-)NCBICHM1_1
T2T-CHM13v2.01732,797,708 - 32,805,083 (-)NCBIT2T-CHM13v2.0
Coprs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,934,787 - 13,940,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,934,794 - 13,940,281 (-)EnsemblGRCm39 Ensembl
GRCm38813,884,787 - 13,890,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,884,794 - 13,890,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv37813,884,788 - 13,890,271 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,884,772 - 13,890,247 (-)NCBIMGSCv36mm8
Celera814,045,092 - 14,050,575 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.41NCBI
Coprs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554816,787,135 - 6,800,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554816,794,088 - 6,797,723 (-)NCBIChiLan1.0ChiLan1.0
COPRS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21932,614,253 - 32,621,661 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11734,493,134 - 34,500,544 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01724,931,356 - 24,938,763 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11725,669,899 - 25,676,859 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1725,669,899 - 25,676,859 (+)Ensemblpanpan1.1panPan2
COPRS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1941,098,226 - 41,104,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl941,102,541 - 41,103,994 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha940,256,947 - 40,263,241 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0941,916,297 - 41,922,540 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl941,916,381 - 41,922,353 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1940,700,384 - 40,706,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0940,994,614 - 41,000,887 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0941,070,836 - 41,077,080 (+)NCBIUU_Cfam_GSD_1.0
COPRS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1243,091,176 - 43,097,994 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11243,091,181 - 43,097,998 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21244,879,988 - 44,886,782 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COPRS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11625,327,180 - 25,334,493 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1625,327,134 - 25,334,413 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660754,743,159 - 4,750,495 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Coprs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248754,345,599 - 4,352,081 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248754,345,593 - 4,352,097 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Coprs
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:113
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000000123
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
RH134484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X54,518,702 - 54,518,961 (+)MAPPERmRatBN7.2
mRatBN7.21675,726,342 - 75,726,556 (+)MAPPERmRatBN7.2
Rnor_6.01680,831,759 - 80,831,972NCBIRnor6.0
Rnor_6.0X58,594,603 - 58,594,861NCBIRnor6.0
Rnor_5.01680,395,980 - 80,396,193UniSTSRnor5.0
Rnor_5.0X59,380,971 - 59,381,229UniSTSRnor5.0
RGSC_v3.4X77,040,681 - 77,040,939UniSTSRGSC3.4
RGSC_v3.41680,562,108 - 80,562,321UniSTSRGSC3.4
Celera1673,535,230 - 73,535,443UniSTS
CeleraX55,032,588 - 55,032,846UniSTS
Cytogenetic Map16q12.5UniSTS
RH124841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21675,726,350 - 75,726,501 (+)MAPPERmRatBN7.2
Rnor_6.01680,831,767 - 80,831,917NCBIRnor6.0
Rnor_5.01680,395,988 - 80,396,138UniSTSRnor5.0
RGSC_v3.41680,562,116 - 80,562,266UniSTSRGSC3.4
Celera1673,535,238 - 73,535,388UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 10 10 6 10 2 74 35 37 7
Low 8 47 31 13 31 8 9 4 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000123   ⟹   ENSRNOP00000000123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1675,721,264 - 75,726,375 (+)Ensembl
Rnor_6.0 Ensembl1680,826,681 - 80,831,791 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095879   ⟹   ENSRNOP00000085951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1675,720,061 - 75,726,375 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098298   ⟹   ENSRNOP00000089318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1675,721,553 - 75,726,375 (+)Ensembl
RefSeq Acc Id: NM_001169121   ⟹   NP_001162592
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,423,480 - 82,428,590 (+)NCBI
mRatBN7.21675,721,264 - 75,726,375 (+)NCBI
Rnor_6.01680,826,681 - 80,831,791 (+)NCBI
Rnor_5.01680,390,902 - 80,396,012 (+)NCBI
RGSC_v3.41680,557,030 - 80,562,140 (+)RGD
Celera1673,530,152 - 73,535,262 (+)RGD
Sequence:
RefSeq Acc Id: XM_063275264   ⟹   XP_063131334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,423,426 - 82,428,821 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001162592   ⟸   NM_001169121
- UniProtKB: A6IWF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000123   ⟸   ENSRNOT00000000123
RefSeq Acc Id: ENSRNOP00000085951   ⟸   ENSRNOT00000095879
RefSeq Acc Id: ENSRNOP00000089318   ⟸   ENSRNOT00000098298
RefSeq Acc Id: XP_063131334   ⟸   XM_063275264
- Peptide Label: isoform X1
- UniProtKB: A6IWF4 (UniProtKB/TrEMBL),   D3ZB92 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZB92-F1-model_v2 AlphaFold D3ZB92 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700222
Promoter ID:EPDNEW_R10746
Type:initiation region
Name:Coprs_1
Description:coordinator of PRMT5 and differentiation stimulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01680,826,693 - 80,826,753EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565675 AgrOrtholog
BioCyc Gene G2FUF-10738 BioCyc
Ensembl Genes ENSRNOG00000000111 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000123 ENTREZGENE
  ENSRNOT00000000123.6 UniProtKB/TrEMBL
  ENSRNOT00000095879.1 UniProtKB/TrEMBL
  ENSRNOT00000098298.1 UniProtKB/TrEMBL
InterPro COPR5 UniProtKB/TrEMBL
NCBI Gene 290925 ENTREZGENE
PANTHER COORDINATOR OF PRMT5 AND DIFFERENTIATION STIMULATOR UniProtKB/TrEMBL
  PTHR36461 UniProtKB/TrEMBL
Pfam COPR5 UniProtKB/TrEMBL
PhenoGen Coprs PhenoGen
RatGTEx ENSRNOG00000000111 RatGTEx
UniProt A0A8I6A2L9_RAT UniProtKB/TrEMBL
  A0A8I6ACF2_RAT UniProtKB/TrEMBL
  A6IWF3 ENTREZGENE, UniProtKB/TrEMBL
  A6IWF4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZB92 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-20 Coprs  coordinator of PRMT5 and differentiation stimulator  Coprs  coordinator of PRMT5, differentiation stimulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-21 Coprs  coordinator of PRMT5, differentiation stimulator  RGD1565675  similar to RIKEN cDNA 2410022L05  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565675  similar to RIKEN cDNA 2410022L05   RGD1565675_predicted  similar to RIKEN cDNA 2410022L05 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565675_predicted  similar to RIKEN cDNA 2410022L05 (predicted)  LOC290925  similar to RIKEN cDNA 2410022L05  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290925  similar to RIKEN cDNA 2410022L05      Symbol and Name status set to provisional 70820 PROVISIONAL