Il2 (interleukin 2) - Rat Genome Database

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Gene: Il2 (interleukin 2) Rattus norvegicus
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Symbol: Il2
Name: interleukin 2
RGD ID: 620047
Description: Enables carbohydrate binding activity; glycosphingolipid binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of T cell activation; positive regulation of dendritic spine development; and regulation of protein phosphorylation. Located in extracellular space. Used to study cystitis. Biomarker of allergic rhinitis; brain infarction; colorectal carcinoma; and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-2; interleukin-2; T-cell growth factor; TCGF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau5 Iddm32
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82121,932,968 - 121,937,672 (-)NCBIGRCr8
mRatBN7.22120,004,862 - 120,009,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,004,862 - 120,009,566 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,574,220 - 126,578,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,686,729 - 124,691,433 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,315,685 - 119,320,389 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,847,150 - 123,851,854 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,847,150 - 123,851,854 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,460,866 - 143,465,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,655,005 - 123,659,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,599,966 - 123,604,671 (-)NCBI
Celera2114,959,889 - 114,964,593 (-)NCBICelera
Cytogenetic Map2q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Il2RatAcute Lung Injury  IEP 6480432protein:increased expression:respiratory system fluid/secretionRGD 
Il2Rataggressive periodontitis  ISOIL2 (Homo sapiens)5147873 RGD 
Il2Ratallergic disease  ISOIl2 (Mus musculus)5147912 RGD 
Il2Ratallergic rhinitis  IEP 8662963 RGD 
Il2Ratalopecia areata  ISOIl2 (Mus musculus)8663450 RGD 
Il2Ratalopecia areata  ISOIL2 (Homo sapiens)8663449 RGD 
Il2RatAlzheimer's disease severityISOIL2 (Homo sapiens)10047081protein:increased secretion:mononuclear cell:RGD 
Il2RatAlzheimer's disease  ISOIL2 (Homo sapiens)10047080 RGD 
Il2RatAmebic Liver Abscess treatmentISOIL2 (Homo sapiens)14928216 RGD 
Il2Ratanogenital venereal wart  ISOIL2 (Homo sapiens)40400714protein:decreased expression:peripheral blood mononuclear cells (human)RGD 
Il2Ratasthma susceptibilityISOIL2 (Homo sapiens)8663473DNA:SNP:promoter:rs2069762(human)RGD 
Il2Ratasthma  ISOIL2 (Homo sapiens)4889118 RGD 
Il2Ratataxia telangiectasia  ISOIL2 (Homo sapiens)8693328 RGD 
Il2Ratatherosclerosis  ISOIl2 (Mus musculus)5147904associated with Diabetes Mellitus and Type 1RGD 
Il2Ratatopic dermatitis  ISOIL2 (Homo sapiens)8662961associated with food hypersensitivityRGD 
Il2Ratatopic dermatitis  ISOIL2 (Homo sapiens)8549583protein:increased expression:CD8+ T cell:RGD 
Il2Ratatopic dermatitis  ISOIL2 (Homo sapiens)8693325 RGD 
Il2Ratatopic dermatitis  ISOIl2 (Mus musculus)8663444 RGD 
Il2Ratatopic dermatitis susceptibilityISOIL2 (Homo sapiens)8663473DNA:SNP:promoter:rs2069762(human)RGD 
Il2Ratatrial fibrillation  ISOIL2 (Homo sapiens)8662962 RGD 
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Il2RatBreast Neoplasms  ISOIL2 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast neoplasmClinVar 
Il2Ratneurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  ISOIL2 (Homo sapiens)8554872ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH HEARING LOSS more ...ClinVarPMID:28492532
Il2RatNeurodevelopmental Disorders  ISOIL2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Il2Ratacquired immunodeficiency syndrome  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:9861562
Il2Ratadult T-cell leukemia/lymphoma  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23962110
Il2Ratallergic contact dermatitis  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11312644 and PMID:22245253
Il2Ratamnestic disorder  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8241462
Il2Ratanemia  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:7678812
Il2RatAnorexia  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8635092
Il2RatAsthenia  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8635092
Il2Ratautistic disorder  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16360218 and PMID:18929414
Il2Ratautoimmune hepatitis  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21227906
Il2RatBrain Injuries  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23159883
Il2RatBrain Neoplasms  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6319491
Il2RatCOVID-19  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31986264
Il2Ratdisease of cellular proliferation  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:12579325
Il2RatDrug Eruptions  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31150805
Il2RatEntamoebiasis  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16374615
Il2RatExperimental Neoplasms  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:1949363 more ...
Il2RatFever  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8635092
Il2Ratglioblastoma  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:7719933
Il2Ratglomerulonephritis  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9403216 and PMID:10910440
Il2Rathuman immunodeficiency virus infectious disease  ISOIL2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12878215
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Original Reference(s)
Il2Ratinflammatory bowel disease  ISSIl2 (Mus musculus)13592920 MouseDO 
Il2RatSjogren's syndrome  ISSIl2 (Mus musculus)13592920OMIM:270150MouseDO 

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Il2Rat(+)-catechin multiple interactionsISOIL2 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of IL2 mRNACTDPMID:24763279
Il2Rat(+)-pilocarpine decreases expressionEXP 6480464Pilocarpine results in decreased expression of IL2 mRNACTDPMID:17971868
Il2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOIL2 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of and results in decreased secretion of IL2 proteinCTDPMID:19761891
Il2Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein]CTDPMID:21195065
Il2Rat(S)-colchicine decreases expressionISOIL2 (Homo sapiens)6480464Colchicine results in decreased expression of IL2 proteinCTDPMID:1553933
Il2Rat(S)-colchicine multiple interactionsISOIL2 (Homo sapiens)6480464[Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNACTDPMID:29594315
Il2Rat(S)-nicotine decreases response to substanceISOIL2 (Homo sapiens)6480464Nicotine results in decreased susceptibility to IL2 proteinCTDPMID:15231866
Il2Rat1,2-dichloroethane multiple interactionsEXP 6480464azoximer bromide inhibits the reaction [ethylene dichloride results in decreased secretion of IL2 protein]CTDPMID:24228488
Il2Rat1,2-dichloroethane decreases secretionEXP 6480464ethylene dichloride results in decreased secretion of IL2 proteinCTDPMID:24228488
Il2Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1 and 2-Dimethylhydrazine] results in decreased expression of IL2 proteinCTDPMID:14736494
Il2Rat1,3-benzothiazole-2-thiol increases secretionISOIl2 (Mus musculus)6480464captax results in increased secretion of IL2 proteinCTDPMID:22245253
Il2Rat1,4-phenylenediamine increases secretionISOIl2 (Mus musculus)64804644-phenylenediamine results in increased secretion of IL2 proteinCTDPMID:22245253
Il2Rat1-chloro-2,4-dinitrobenzene increases expressionISOIl2 (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of IL2 mRNA and Dinitrochlorobenzene results in increased expression of IL2 proteinCTDPMID:15588918 more ...
Il2Rat1-chloro-2,4-dinitrobenzene increases secretionISOIl2 (Mus musculus)6480464Dinitrochlorobenzene results in increased secretion of IL2 proteinCTDPMID:22245253
Il2Rat1-fluoro-2,4-dinitrobenzene increases expressionISOIl2 (Mus musculus)6480464Dinitrofluorobenzene results in increased expression of IL2 mRNA and Dinitrofluorobenzene results in increased expression of IL2 proteinCTDPMID:11244134 and PMID:22381623
Il2Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISOIl2 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:30195017
Il2Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOIl2 (Mus musculus)6480464TGM2 protein affects the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:30195017
Il2Rat1-naphthaleneacetic acid increases expressionISOIl2 (Mus musculus)64804641-naphthaleneacetic acid results in increased expression of IL2CTDPMID:20728597
Il2Rat15-acetyldeoxynivalenol affects secretionISOIl2 (Mus musculus)648046415-acetyldeoxynivalenol affects the secretion of IL2 proteinCTDPMID:8560498
Il2Rat15-acetyldeoxynivalenol increases expressionISOIl2 (Mus musculus)648046415-acetyldeoxynivalenol results in increased expression of IL2 mRNACTDPMID:8560498

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Biological Process
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Il2Ratactivated T cell proliferation acts_upstream_ofISOIl2 (Mus musculus)1624291MGI:1857191 PMID:10485657 more ...RGDPMID:10485657 more ...
Il2Ratadaptive immune response involved_inIEAUniProtKB-KW:KW-10641600115GO_REF:0000043UniProtGO_REF:0000043
Il2Ratcell surface receptor signaling pathway via STAT involved_inISOIL2 (Homo sapiens)1624291 PMID:19088061RGDPMID:19088061
Il2Ratcell surface receptor signaling pathway via STAT involved_inIEAUniProtKB:P60568 and ensembl:ENSP000002267301600115GO_REF:0000107EnsemblGO_REF:0000107
Il2Ratextrinsic apoptotic signaling pathway in absence of ligand acts_upstream_of_or_withinISOIl2 (Mus musculus)1624291 PMID:12082633RGDPMID:12082633
Il2RatG protein-coupled receptor signaling pathway  IMP 727354 RGD 
Il2Ratgene expression acts_upstream_of_or_withinISOIl2 (Mus musculus)1624291 PMID:28396406RGDPMID:28396406
Il2Ratimmune response involved_inIEAInterPro:IPR0007791600115GO_REF:0000002InterProGO_REF:0000002
Il2Ratimmune system process involved_inIEAUniProtKB-KW:KW-03911600115GO_REF:0000043UniProtGO_REF:0000043
Il2Ratinterleukin-2-mediated signaling pathway involved_inISOIL2 (Homo sapiens)1624291 PMID:22844114RGDPMID:22844114
Il2Ratinterleukin-2-mediated signaling pathway involved_inIEAUniProtKB:P60568 and ensembl:ENSP000002267301600115GO_REF:0000107EnsemblGO_REF:0000107
Il2Ratinterleukin-2-mediated signaling pathway involved_inIBAPANTHER:PTN009232670 and UniProtKB:P605681600115GO_REF:0000033GO_CentralGO_REF:0000033
Il2Ratleukocyte activation involved in immune response involved_inISOIL2 (Homo sapiens)1624291 PMID:16204630RGDPMID:16204630
Il2Ratleukocyte activation involved in immune response involved_inIEAUniProtKB:P60568 and ensembl:ENSP000002267301600115GO_REF:0000107EnsemblGO_REF:0000107
Il2Ratlymphocyte proliferation acts_upstream_ofISOIl2 (Mus musculus)1624291MGI:1857191 PMID:16227984RGDPMID:16227984
Il2Ratnegative regulation of B cell apoptotic process acts_upstream_of_or_withinISOIL2 (Homo sapiens)1624291 PMID:9184696RGDPMID:9184696
Il2Ratnegative regulation of B cell apoptotic process acts_upstream_of_or_withinIEAUniProtKB:P60568 and ensembl:ENSP000002267301600115GO_REF:0000107EnsemblGO_REF:0000107
Il2Ratnegative regulation of inflammatory response acts_upstream_of_or_withinISOIl2 (Mus musculus)1624291MGI:1857191 PMID:7589135 and PMID:8402910RGDPMID:7589135 and PMID:8402910
Il2Ratnegative regulation of lymphocyte proliferation acts_upstream_of_or_withinISOIl2 (Mus musculus)1624291MGI:1857191 PMID:16227984RGDPMID:16227984
Il2Ratnegative regulation of protein phosphorylation  IDA 1600106 RGD 
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Cellular Component
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Original Reference(s)
Il2Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Il2Ratextracellular region located_inIEAInterPro:IPR0007791600115GO_REF:0000002InterProGO_REF:0000002
Il2Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Il2Ratextracellular space  IDA 1600098 RGD 
Il2Ratextracellular space located_inIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Il2Ratextracellular space located_inISOIl2 (Mus musculus)1624291 PMID:10072077 more ...RGDPMID:10072077 more ...
Il2Ratextracellular space is_active_inISOIL2 (Homo sapiens)1624291 PMID:18273057RGDPMID:18273057
Il2Ratextracellular space is_active_inIEAUniProtKB:P60568 and ensembl:ENSP000002267301600115GO_REF:0000107EnsemblGO_REF:0000107
Il2Ratextracellular space is_active_inIBAMGI:96548 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Il2Ratcarbohydrate binding  IDA 1600093binds gangliosides GM1 more ...RGD 
Il2Ratcytokine activity  IDA 2303493 RGD 
Il2Ratcytokine activity enablesIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Il2Ratcytokine activity enablesIEAUniProtKB:P60568 and ensembl:ENSP000002267301600115GO_REF:0000107EnsemblGO_REF:0000107
Il2Ratcytokine activity enablesISOIl2 (Mus musculus)1624291 PMID:10485657 more ...RGDPMID:10485657 more ...
Il2Ratcytokine activity enablesIBAMGI:96548 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il2Ratcytokine activity enablesISOIL2 (Homo sapiens)1624291 PMID:10072077 more ...RGDPMID:10072077 more ...
Il2Ratglycosphingolipid binding  IDA 1600093binds gangliosides GM1 more ...RGD 
Il2Ratgrowth factor activity enablesIEAUniProtKB-KW:KW-03391600115GO_REF:0000043UniProtGO_REF:0000043
Il2Ratgrowth factor activity enablesIEAInterPro:IPR0007791600115GO_REF:0000002InterProGO_REF:0000002
Il2Ratinterleukin-2 receptor binding  IMP 1600106 RGD 
Il2Ratinterleukin-2 receptor binding enablesIEAInterPro:IPR0007791600115GO_REF:0000002InterProGO_REF:0000002
Il2Ratinterleukin-2 receptor binding enablesIEAUniProtKB:P60568 and ensembl:ENSP000002267301600115GO_REF:0000107EnsemblGO_REF:0000107
Il2Ratinterleukin-2 receptor binding enablesISOIl2 (Mus musculus)1624291 PMID:1588041 more ...RGDPMID:1588041 more ...
Il2Ratinterleukin-2 receptor binding enablesIBAMGI:96548 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il2Ratinterleukin-2 receptor binding enablesISOIL2 (Homo sapiens)1624291 PMID:8262055RGDPMID:8262055
Il2Ratkappa-type opioid receptor binding  IMP 727354 RGD 
Il2Ratprotein binding enablesISOIL2 (Homo sapiens)1624291UniProtKB:P01589 more ...RGDPMID:16477002 more ...
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Imported Annotations - KEGG (archival)

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Il2Ratallograft rejection pathway  IEA 6907045 KEGGrno:05330
Il2Ratautoimmune thyroiditis pathway  IEA 6907045 KEGGrno:05320
Il2RatChagas disease pathway  IEA 6907045 KEGGrno:05142
Il2Ratcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
Il2Ratgraft-versus-host disease pathway  IEA 6907045 KEGGrno:05332
Il2RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Il2Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Il2RatT cell receptor signaling pathway  IEA 6907045 KEGGrno:04660
Il2Rattype 1 diabetes mellitus pathway  IEA 6907045 KEGGrno:04940
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Imported Annotations - PID (archival)


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Reference Title
Reference Citation
1. Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model. Adam B, etal., Pain. 2006 Jul;123(1-2):179-86. Epub 2006 Apr 12.
2. Tumour necrosis factor-alpha and interleukin-2 in pus aspirate and blood in patients with amoebic liver abscess. Agarwal SK, etal., J Assoc Physicians India. 1999 Nov;47(11):1065-7.
3. Immunologic studies in patients with Takayasu's arteritis. III. Immunoregulatory changes. Alcocer-Varela J, etal., Clin Exp Rheumatol. 1989 Jul-Aug;7(4):345-50.
4. Immunological predictors of different responses to combination therapy with interferon alpha and ribavirin in patients with chronic hepatitis C. Amaraa R, etal., J Gastroenterol. 2003;38(3):254-9. doi: 10.1007/s005350300044.
5. Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma. Antunez C, etal., Pediatr Allergy Immunol. 2006 May;17(3):166-74.
6. T cell-mediated eradication of murine metastatic melanoma induced by targeted interleukin 2 therapy. Becker JC, etal., J Exp Med. 1996 May 1;183(5):2361-6. doi: 10.1084/jem.183.5.2361.
7. Eradication of human hepatic and pulmonary melanoma metastases in SCID mice by antibody-interleukin 2 fusion proteins. Becker JC, etal., Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2702-7.
8. Expression of immunoregulatory cytokines during acute and chronic middle ear immune response. Bikhazi P and Ryan AF, Laryngoscope. 1995 Jun;105(6):629-34.
9. In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2. Bui LA, etal., Hum Gene Ther. 1997 Dec 10;8(18):2173-82. doi: 10.1089/hum.1997.8.18-2173.
10. Interleukin 1 (IL-1) and IL-1-receptor antagonist (IL-1-RA) in middle ear cholesteatoma: an analysis of protein production and biological activity. Bujia J, etal., Eur Arch Otorhinolaryngol. 1996;253(4-5):252-5.
11. In vivo effects of recombinant human interleukin 2 on antitumor and antiviral natural immunity in induced or natural murine immunodeficiency states. Butler LD, etal., Cancer Res. 1988 Nov 1;48(21):6081-9.
12. Opioid receptor-mediated effects of interleukin-2 on the [Ca2+]i transient and contraction in isolated ventricular myocytes of the rat. Cao CM, etal., Pflugers Arch 2002 Feb;443(4):635-42.
13. Efficacy of Large Doses of IL-2-Activated Human Leukocyte Antigen Haploidentical Peripheral Blood Stem Cells on Refractory Metastatic Renal Cell Carcinoma. Cao S, etal., Cancer Biother Radiopharm. 2011 Aug;26(4):503-10. Epub 2011 Aug 3.
14. Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats. Case JP, etal., Proc Natl Acad Sci U S A. 1989 Jan;86(1):287-91.
15. Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats. Cata JP, etal., Neurosci Lett. 2008 May 23;437(1):45-9. doi: 10.1016/j.neulet.2008.03.074. Epub 2008 Mar 29.
16. Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model. Chaitanya GV, etal., Neuroscience. 2010 Feb 17;165(4):1203-16. Epub 2009 Nov 4.
17. Mechanism of the impaired T-cell proliferation in adult rats exposed to alcohol in utero. Chang MP, etal., Int J Immunopharmacol. 1994 Apr;16(4):345-57.
18. Comparison of the expression of interferon gamma, IL2, IL4, and lymphotoxin mRNA in experimental autoimmune uveoretinitis. Charteris DG and Lightman SL, Br J Ophthalmol. 1994 Oct;78(10):786-90.
19. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
20. Delayed reactions to contrast media after interleukin-2 immunotherapy. Choyke PL, etal., Radiology. 1992 Apr;183(1):111-4.
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PMID:1588041   PMID:1830926   PMID:7584142   PMID:7589135   PMID:7688139   PMID:8262055   PMID:8402910   PMID:8612131   PMID:9184696   PMID:9492004   PMID:10072077   PMID:10485657  
PMID:11728336   PMID:11948286   PMID:12082633   PMID:12874832   PMID:12878449   PMID:15087456   PMID:15950774   PMID:16204630   PMID:16227984   PMID:16482511   PMID:16769892   PMID:17152351  
PMID:17213291   PMID:17433709   PMID:18264770   PMID:18343154   PMID:18407603   PMID:18471351   PMID:18628674   PMID:18827184   PMID:19088061   PMID:19139201   PMID:19589546   PMID:21262542  
PMID:21668966   PMID:21726905   PMID:22201020   PMID:22659252   PMID:22968459   PMID:23262141   PMID:23395675   PMID:24853588   PMID:25642768   PMID:26927369   PMID:28092075   PMID:28396406  
PMID:37464198  



Il2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82121,932,968 - 121,937,672 (-)NCBIGRCr8
mRatBN7.22120,004,862 - 120,009,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,004,862 - 120,009,566 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,574,220 - 126,578,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,686,729 - 124,691,433 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,315,685 - 119,320,389 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,847,150 - 123,851,854 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,847,150 - 123,851,854 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,460,866 - 143,465,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,655,005 - 123,659,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,599,966 - 123,604,671 (-)NCBI
Celera2114,959,889 - 114,964,593 (-)NCBICelera
Cytogenetic Map2q25NCBI
IL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,451,470 - 122,456,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,451,470 - 122,456,725 (-)EnsemblGRCh38hg38GRCh38
GRCh374123,372,625 - 123,377,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,592,075 - 123,597,100 (-)NCBINCBI36Build 36hg18NCBI36
Build 344123,730,232 - 123,735,485NCBI
Celera4120,756,030 - 120,761,055 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4119,099,231 - 119,104,256 (-)NCBIHuRef
CHM1_14123,349,113 - 123,354,138 (-)NCBICHM1_1
T2T-CHM13v2.04125,755,609 - 125,760,864 (-)NCBIT2T-CHM13v2.0
Il2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,174,862 - 37,180,103 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,174,672 - 37,180,108 (-)EnsemblGRCm39 Ensembl
GRCm38337,120,713 - 37,125,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,120,523 - 37,125,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,019,635 - 37,024,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,312,271 - 37,317,502 (-)NCBIMGSCv36mm8
Celera337,007,247 - 37,012,480 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.3NCBI
Il2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,162,467 - 18,168,265 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,163,010 - 18,168,157 (+)NCBIChiLan1.0ChiLan1.0
IL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,236,205 - 120,241,463 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,502,088 - 120,507,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04114,637,328 - 114,642,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,782,563 - 125,787,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,782,563 - 125,787,984 (-)Ensemblpanpan1.1panPan2
IL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,750,780 - 17,756,394 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,750,780 - 17,756,394 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,968,837 - 17,974,439 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,869,103 - 17,874,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,869,103 - 17,874,712 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,821,680 - 17,827,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01918,101,949 - 18,107,555 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,572,248 - 18,577,858 (+)NCBIUU_Cfam_GSD_1.0
Il2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,520,154 - 65,524,908 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,594,953 - 1,599,625 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,594,953 - 1,599,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,640,944 - 101,645,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,640,938 - 101,645,683 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,797,437 - 108,802,149 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,729,635 - 69,736,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,730,282 - 69,734,969 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603748,691,838 - 48,697,094 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247772,885,535 - 2,890,453 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247772,885,537 - 2,890,453 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Il2
8 total Variants

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:37
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000023327
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 62 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat

1 to 10 of 62 rows
UniSTS:143556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22120,009,437 - 120,009,507 (+)MAPPERmRatBN7.2
Rnor_6.02123,851,726 - 123,851,795NCBIRnor6.0
Rnor_5.02143,465,442 - 143,465,511UniSTSRnor5.0
RGSC_v3.42123,659,581 - 123,659,650UniSTSRGSC3.4
Celera2114,964,465 - 114,964,534UniSTS
Cytogenetic Map2q25UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 2 5 15 19 29 5 21 5 4 46 31 7 2 18 24



Ensembl Acc Id: ENSRNOT00000023327   ⟹   ENSRNOP00000023327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2120,004,862 - 120,009,566 (-)Ensembl
Rnor_6.0 Ensembl2123,847,150 - 123,851,854 (-)Ensembl
RefSeq Acc Id: NM_053836   ⟹   NP_446288
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82121,932,968 - 121,937,672 (-)NCBI
mRatBN7.22120,004,862 - 120,009,566 (-)NCBI
Rnor_6.02123,847,150 - 123,851,854 (-)NCBI
Rnor_5.02143,460,866 - 143,465,570 (-)NCBI
RGSC_v3.42123,655,005 - 123,659,709 (-)RGD
Celera2114,959,889 - 114,964,593 (-)RGD
Sequence:
Protein RefSeqs NP_446288 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41427 (Get FASTA)   NCBI Sequence Viewer  
  EDM01295 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023327
  ENSRNOP00000023327.1
GenBank Protein P17108 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446288   ⟸   NM_053836
- Peptide Label: precursor
- UniProtKB: P17108 (UniProtKB/Swiss-Prot),   A6IHZ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023327   ⟸   ENSRNOT00000023327

Name Modeler Protein Id AA Range Protein Structure
AF-P17108-F1-model_v2 AlphaFold P17108 1-155 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-53309 BioCyc
Ensembl Genes ENSRNOG00000017348 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023327 ENTREZGENE
  ENSRNOT00000023327.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-2 UniProtKB/Swiss-Prot
  IL-2_CS UniProtKB/Swiss-Prot
KEGG Report rno:116562 UniProtKB/Swiss-Prot
NCBI Gene 116562 ENTREZGENE
PANTHER INTERLEUKIN-2 UniProtKB/Swiss-Prot
  INTERLEUKIN-2 UniProtKB/Swiss-Prot
Pfam IL2 UniProtKB/Swiss-Prot
PhenoGen Il2 PhenoGen
PRINTS INTERLEUKIN2 UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017348 RatGTEx
SMART IL2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A6IHZ7 ENTREZGENE, UniProtKB/TrEMBL
  IL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Il2  interleukin 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il2  interleukin 2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_process involved in contraction in vetricular myocytes 727354
gene_regulation mRNA level dramatically increases after cyclophosphamide (CYP)-induced cystitis 625630