Csf3 (colony stimulating factor 3) - Rat Genome Database

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Gene: Csf3 (colony stimulating factor 3) Rattus norvegicus
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Symbol: Csf3
Name: colony stimulating factor 3
RGD ID: 2426
Description: Enables growth factor activity. Involved in cellular response to lipopolysaccharide; positive regulation of cell population proliferation; and response to ethanol. Located in extracellular space. Biomarker of cystitis; lung disease; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; malaria pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: colony stimulating factor 3 (granulocyte); Gcsf; granulocyte colony-stimulating factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,157,485 - 84,159,860 (+)NCBIGRCr8
mRatBN7.21083,660,787 - 83,664,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,661,207 - 83,663,603 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,605,117 - 88,607,492 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,103,193 - 88,105,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,495,892 - 83,498,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,616,785 - 86,619,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,616,785 - 86,619,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,413,088 - 86,415,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,473,990 - 87,476,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,488,359 - 87,490,732 (+)NCBI
Celera1082,409,331 - 82,411,709 (+)NCBICelera
RH 3.4 Map10850.39RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Csf3RatAcute Liver Failure treatmentISOCSF3 (Homo sapiens)11039421 RGD 
Csf3RatAcute Liver Failure treatmentISOCSF3 (Homo sapiens)11039537 RGD 
Csf3Ratacute lymphoblastic leukemia treatmentISOCSF3 (Homo sapiens)11039038 RGD 
Csf3Ratacute myeloid leukemia treatmentISOCSF3 (Homo sapiens)11039033 RGD 
Csf3Ratallergic cutaneous vasculitis treatmentISOCSF3 (Homo sapiens)11039037associated with Severe Congenital NeutropeniaRGD 
Csf3Ratanterior ischemic optic neuropathy treatmentISOCSF3 (Homo sapiens)11039419 RGD 
Csf3RatAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  ISOCSF3 (Homo sapiens)11039411protein:increased expression:serum:RGD 
Csf3Ratasthma  ISOCSF3 (Homo sapiens)5133731 RGD 
Csf3Ratasthma  ISOCsf3 (Mus musculus)5131473protein:increased expression:lungRGD 
Csf3Ratbacterial pneumonia treatmentISOCSF3 (Homo sapiens)11039437associated with PeritonitisRGD 
Csf3Ratbacterial pneumonia disease_progressionISOCSF3 (Homo sapiens)5133733 RGD 
Csf3RatBrain Injuries treatmentISOCSF3 (Homo sapiens)11039431 RGD 
Csf3Ratbrain ischemia  ISOCSF3 (Homo sapiens)2311241associated with Diabetes Mellitus and ExperimentalRGD 
Csf3RatCardiac Fibrosis  ISOCSF3 (Homo sapiens)11039480associated with Myocardial InfarctionRGD 
Csf3RatCarotid Artery Injuries  IEP 11039423protein:increased expression:smooth muscle cell:RGD 
Csf3RatCerebral Hemorrhage treatmentISOCSF3 (Homo sapiens)11039433 RGD 
Csf3Ratcognitive disorder treatmentISOCSF3 (Homo sapiens)11039464associated with Status EpilepticusRGD 
Csf3RatCOVID-19 severityISOCSF3 (Homo sapiens)30309209protein:increased expression:plasma (human)RGD 
Csf3RatCOVID-19 severityISOCSF3 (Homo sapiens)30309212protein:increased expression:plasma (human)RGD 
Csf3Ratcystitis  IEP 2317284protein:increased expression:urinary bladderRGD 
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Original Reference(s)
Csf3Rathypertrophic cardiomyopathy 25  ISOCSF3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathy 25ClinVarPMID:28492532
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Csf3RatAcute Liver Failure  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21550386
Csf3Ratacute myeloid leukemia  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:7528855
Csf3Ratagranulocytosis  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15999287
Csf3Ratanemia  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12085204 more ...
Csf3Ratangiosarcoma  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:9774950
Csf3RatAnimal Disease Models  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:27737899
Csf3Rataplastic anemia  ISOCSF3 (Homo sapiens)11554173CTD more ...CTDPMID:1642096 more ...
Csf3RatArthralgia  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7543699
Csf3RatB-cell lymphoma  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:11042651
Csf3Ratbilirubin metabolic disorder  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8602625
Csf3RatBone Marrow Neoplasms  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20026017
Csf3RatBrain Injuries  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21549006
Csf3RatBreast Neoplasms  ISOCSF3 (Homo sapiens)11554173CTD more ...CTDPMID:7541186 more ...
Csf3Ratcarcinoma  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:9018096
Csf3RatChemical and Drug Induced Liver Injury  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20005281 and PMID:33882750
Csf3Ratcongestive heart failure  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15585077
Csf3RatCOVID-19  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31986264
Csf3Ratdepressive disorder  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9018096
Csf3Ratdiarrhea  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7543699
Csf3Ratdilated cardiomyopathy  ISOCSF3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17334414
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Csf3Rat1,3,5-trinitro-1,3,5-triazinane increases expressionEXP 6480464cyclonite results in increased expression of CSF3 mRNACTDPMID:25559034
Csf3Rat1-chloro-2,4-dinitrobenzene increases expressionISOCsf3 (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of CSF3 mRNACTDPMID:18652873
Csf3Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOCsf3 (Mus musculus)6480464CSF3 protein inhibits the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:27044752
Csf3Rat17beta-estradiol increases expressionISOCSF3 (Homo sapiens)6480464Estradiol results in increased expression of CSF3 mRNACTDPMID:16298037
Csf3Rat17beta-estradiol affects expressionISOCSF3 (Homo sapiens)6480464Estradiol affects the expression of CSF3 mRNACTDPMID:22574217
Csf3Rat17beta-estradiol multiple interactionsISOCSF3 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of CSF3 mRNA and [Progesterone co-treated with Estradiol] results in increased expression of CSF3 mRNACTDPMID:17404688 and PMID:30165855
Csf3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCsf3 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in increased expression of CSF3 mRNA]CTDPMID:22749964
Csf3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CSF3 mRNACTDPMID:33387578
Csf3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCSF3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of CSF3 mRNACTDPMID:28351761
Csf3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCsf3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CSF3 mRNACTDPMID:26377647
Csf3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCsf3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CSF3 mRNACTDPMID:12167310 more ...
Csf3Rat2,4,6-trinitrobenzenesulfonic acid increases expressionISOCsf3 (Mus musculus)6480464Trinitrobenzenesulfonic Acid results in increased expression of CSF3 proteinCTDPMID:23596210
Csf3Rat2,5-dichlorophenol increases expressionISOCSF3 (Homo sapiens)64804642 and 5-dichlorophenol results in increased expression of CSF3 mRNACTDPMID:38568856
Csf3Rat2-amino-2-deoxy-D-glucopyranose multiple interactionsEXP 6480464Glucosamine inhibits the reaction [IL1B results in increased expression of CSF3 mRNA]CTDPMID:17109745
Csf3Rat2-amino-2-deoxy-D-glucopyranose increases expressionEXP 6480464Glucosamine results in increased expression of CSF3 mRNACTDPMID:17109745
Csf3Rat3',5'-cyclic AMP increases expressionISOCSF3 (Homo sapiens)6480464Cyclic AMP results in increased expression of CSF3 proteinCTDPMID:7540958
Csf3Rat3,3',4,4',5-pentachlorobiphenyl increases expressionISOCSF3 (Homo sapiens)64804643 more ...CTDPMID:28351761 and PMID:35618242
Csf3Rat3,3',4,4',5-pentachlorobiphenyl increases secretionISOCsf3 (Mus musculus)64804643 more ...CTDPMID:29216392
Csf3Rat3-acetyldeoxynivalenol increases expressionISOCsf3 (Mus musculus)64804643-acetyldeoxynivalenol results in increased expression of CSF3 mRNACTDPMID:35413383
Csf3Rat3-acetyldeoxynivalenol multiple interactionsISOCsf3 (Mus musculus)64804644-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF3 mRNA]CTDPMID:35413383

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Biological Process
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Original Reference(s)
Csf3Ratcellular response to cytokine stimulus involved_inISOCSF3 (Homo sapiens)1624291 PMID:23001182RGDPMID:23001182
Csf3Ratcellular response to lipopolysaccharide  IEP 5133735 RGD 
Csf3Ratgranulocyte colony-stimulating factor signaling pathway involved_inISOCSF3 (Homo sapiens)1624291 PMID:23001182RGDPMID:23001182
Csf3Ratimmune response involved_inIEAInterPro:IPR0304741600115GO_REF:0000002InterProGO_REF:0000002
Csf3Ratpositive regulation of actin filament polymerization involved_inISOCSF3 (Homo sapiens)1624291 PMID:23001182RGDPMID:23001182
Csf3Ratpositive regulation of cell population proliferation  IDA 1298819 RGD 
Csf3Ratpositive regulation of cell population proliferation involved_inIBAPANTHER:PTN008500529 and Csf3 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Csf3Ratpositive regulation of myeloid cell differentiation involved_inIBAMGI:1339751 and PANTHER:PTN0085005291600115GO_REF:0000033GO_CentralGO_REF:0000033
Csf3Ratpositive regulation of myeloid cell differentiation acts_upstream_of_or_withinISOCsf3 (Mus musculus)1624291MGI:1345151 PMID:24216483RGDPMID:24216483
Csf3Ratpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_inISOCSF3 (Homo sapiens)1624291 PMID:23001182RGDPMID:23001182
Csf3Ratpositive regulation of transcription by RNA polymerase II involved_inISOCSF3 (Homo sapiens)1624291 PMID:23001182RGDPMID:23001182
Csf3Ratregulation of actin filament organization involved_inISOCSF3 (Homo sapiens)1624291 PMID:23001182RGDPMID:23001182
Csf3Ratresponse to ethanol  IEP 11039473 RGD 
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Cellular Component

  
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Csf3Ratextracellular space  IDA 5133735 RGD 
Csf3Ratextracellular space is_active_inIBAPANTHER:PTN008500529 and Csf3 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  

Imported Annotations - KEGG (archival)

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Csf3Ratcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
Csf3RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Csf3Ratmalaria pathway  IEA 6907045 KEGGrno:05144

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#
Reference Title
Reference Citation
1. Effects of granulocyte colony-stimulating factor (G-CSF) on bleomycin-induced lung injury of varying severity. Adachi K, etal., Toxicol Pathol. 2003 Nov-Dec;31(6):665-73.
2. Granulocyte colony-stimulating factor enhances host defenses against bacterial pneumonia following peritonitis in nonneutropenic rats. Attalah HL, etal., Crit Care Med. 2002 Sep;30(9):2107-14.
3. Granulocyte colony-stimulating factor enhances alpha-naphthylthiourea-induced pulmonary hypertension. Azoulay E, etal., J Appl Physiol (1985). 2003 May;94(5):2027-33. Epub 2003 Jan 10.
4. Suppression of the granulocyte colony-stimulating factor response to Escherichia coli challenge by alcohol intoxication. Bagby GJ, etal., Alcohol Clin Exp Res. 1998 Nov;22(8):1740-5.
5. Treatment of adjuvant arthritis with granulocyte-colony stimulating factor and peptide derived from heat shock protein 65. Brendolan A, etal., Cell Immunol. 2003 Jan;221(1):6-14.
6. Granulocyte colony-stimulating factor serum and urine concentrations in neutropenic neonates before and after intravenous administration of recombinant granulocyte colony-stimulating factor. Calhoun DA, etal., Pediatrics. 2000 Feb;105(2):392-7.
7. Neuroprotective effects of recombinant human granulocyte colony-stimulating factor (G-CSF) in a rat model of anterior ischemic optic neuropathy (rAION). Chang CH, etal., Exp Eye Res. 2014 Jan;118:109-16. doi: 10.1016/j.exer.2013.11.012. Epub 2013 Dec 5.
8. Co-delivery of G-CSF and EPO released from fibrin gel for therapeutic neovascularization in rat hindlimb ischemia model. Chen F, etal., Microcirculation. 2013 Jul;20(5):416-24. doi: 10.1111/micc.12037.
9. Expression of granulocyte colony-stimulating factor is induced in injured rat carotid arteries and mediates vascular smooth muscle cell migration. Chen X, etal., Am J Physiol Cell Physiol. 2005 Jan;288(1):C81-8. Epub 2004 Sep 22.
10. Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion. Cheng Z, etal., Cardiovasc Res. 2008 Dec 1;80(3):425-34. doi: 10.1093/cvr/cvn202. Epub 2008 Jul 31.
11. Granulocyte colony stimulating factor neuroprotective effects on spinal motoneurons after ventral root avulsion. De Freria CM, etal., Synapse. 2012 Feb;66(2):128-41. doi: 10.1002/syn.20993. Epub 2011 Nov 3.
12. Effects of granulocyte colony stimulating factor in a nonneutropenic rodent model of Escherichia coli peritonitis. Dunne JR, etal., J Surg Res. 1996 Mar;61(2):348-54.
13. Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis. Freeley SJ, etal., Ann Rheum Dis. 2013 Jun;72(6):1053-8. doi: 10.1136/annrheumdis-2012-202160. Epub 2012 Oct 19.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Therapy for neutropenia in hairy cell leukemia with recombinant human granulocyte colony-stimulating factor. Glaspy JA, etal., Ann Intern Med. 1988 Nov 15;109(10):789-95.
16. Cloning and expression of the cDNA encoding rat granulocyte colony-stimulating factor. Han SW, etal., Gene 1996 Oct 10;175(1-2):101-4.
17. Granulocyte colony-stimulating factor after intensive consolidation chemotherapy in acute myeloid leukemia: results of a randomized trial of the Groupe Ouest-Est Leucemies Aigues Myeloblastiques. Harousseau JL, etal., J Clin Oncol. 2000 Feb;18(4):780-7.
18. Hemorrhagic shock induces G-CSF expression in bronchial epithelium. Hierholzer C, etal., Am J Physiol. 1997 Nov;273(5 Pt 1):L1058-64.
19. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
20. Granulocyte colony stimulating factor attenuates hyperoxia-induced lung injury by down-modulating inflammatory responses in neonatal rats. Jeon GW, etal., Yonsei Med J. 2011 Jan 1;52(1):65-73.
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PMID:2158861   PMID:12393522   PMID:17681181   PMID:21292035   PMID:21461559   PMID:22099173   PMID:23001182   PMID:23209732   PMID:23437199   PMID:24167558   PMID:24216483   PMID:25144367  
PMID:25425079   PMID:28176642  



Csf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,157,485 - 84,159,860 (+)NCBIGRCr8
mRatBN7.21083,660,787 - 83,664,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,661,207 - 83,663,603 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,605,117 - 88,607,492 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,103,193 - 88,105,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,495,892 - 83,498,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,616,785 - 86,619,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,616,785 - 86,619,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,413,088 - 86,415,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,473,990 - 87,476,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,488,359 - 87,490,732 (+)NCBI
Celera1082,409,331 - 82,411,709 (+)NCBICelera
RH 3.4 Map10850.39RGD
Cytogenetic Map10q31NCBI
CSF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,015,440 - 40,017,813 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,015,361 - 40,017,813 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,171,693 - 38,174,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,425,214 - 35,427,592 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,425,213 - 35,427,591NCBI
Celera1734,831,674 - 34,834,127 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1733,965,611 - 33,968,064 (+)NCBIHuRef
CHM1_11738,407,306 - 38,409,759 (+)NCBICHM1_1
T2T-CHM13v2.01740,879,315 - 40,881,689 (+)NCBIT2T-CHM13v2.0
Csf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,591,287 - 98,594,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,592,089 - 98,594,455 (+)EnsemblGRCm39 Ensembl
GRCm381198,700,183 - 98,703,631 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,701,263 - 98,703,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,562,627 - 98,564,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,517,403 - 98,519,719 (+)NCBIMGSCv36mm8
Celera11108,355,655 - 108,357,971 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.45NCBI
Csf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,688,181 - 14,690,126 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,688,181 - 14,690,126 (+)NCBIChiLan1.0ChiLan1.0
CSF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,936,910 - 24,939,329 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,831,703 - 26,834,122 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,271,074 - 17,273,493 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,491,272 - 17,493,729 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,491,276 - 17,493,729 (-)Ensemblpanpan1.1panPan2
CSF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,529,643 - 22,532,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,530,698 - 22,533,108 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,001,811 - 22,004,573 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,322,490 - 23,325,252 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,323,327 - 23,325,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,095,850 - 22,098,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,355,055 - 22,357,817 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,479,613 - 22,482,375 (-)NCBIUU_Cfam_GSD_1.0
Csf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,929,893 - 21,934,092 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,142,808 - 15,144,487 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,142,526 - 15,146,375 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,333,449 - 22,338,753 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,333,445 - 22,335,949 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,732,713 - 22,734,736 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,162,814 - 66,166,192 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,163,681 - 66,165,172 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,070,211 - 37,072,804 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,163,009 - 3,166,594 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,162,999 - 3,167,248 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Csf3
13 total Variants

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:73
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000011509
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 79 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat

1 to 10 of 79 rows
RH94653  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81084,159,659 - 84,159,818 (+)Marker Load Pipeline
mRatBN7.21083,663,402 - 83,663,561 (+)MAPPERmRatBN7.2
Rnor_6.01086,618,960 - 86,619,118NCBIRnor6.0
Rnor_5.01086,415,278 - 86,415,436UniSTSRnor5.0
RGSC_v3.41087,476,165 - 87,476,323UniSTSRGSC3.4
Celera1082,411,509 - 82,411,667UniSTS
RH 3.4 Map10850.39UniSTS
Cytogenetic Map10q31UniSTS
PMC316809P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,662,492 - 83,663,166 (+)MAPPERmRatBN7.2
Rnor_6.01086,618,050 - 86,618,723NCBIRnor6.0
Rnor_5.01086,414,368 - 86,415,041UniSTSRnor5.0
RGSC_v3.41087,475,255 - 87,475,928UniSTSRGSC3.4
Celera1082,410,599 - 82,411,272UniSTS
Cytogenetic Map10q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 1 2 13 20 27 4 17 4 6 65 23 6 33 46 23



Ensembl Acc Id: ENSRNOT00000011509   ⟹   ENSRNOP00000011509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,661,207 - 83,663,603 (+)Ensembl
Rnor_6.0 Ensembl1086,616,785 - 86,619,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112863   ⟹   ENSRNOP00000089962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,661,228 - 83,662,974 (+)Ensembl
RefSeq Acc Id: NM_017104   ⟹   NP_058800
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81084,157,485 - 84,159,860 (+)NCBI
mRatBN7.21083,661,228 - 83,663,603 (+)NCBI
Rnor_6.01086,616,785 - 86,619,160 (+)NCBI
Rnor_5.01086,413,088 - 86,415,478 (+)NCBI
RGSC_v3.41087,473,990 - 87,476,365 (+)RGD
Celera1082,409,331 - 82,411,709 (+)RGD
Sequence:
Protein RefSeqs NP_058800 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52915 (Get FASTA)   NCBI Sequence Viewer  
  EDM05943 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011509.4
  ENSRNOP00000089962.1
RefSeq Acc Id: NP_058800   ⟸   NM_017104
- Peptide Label: precursor
- UniProtKB: A6HIT8 (UniProtKB/TrEMBL),   F7FGY7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011509   ⟸   ENSRNOT00000011509
Ensembl Acc Id: ENSRNOP00000089962   ⟸   ENSRNOT00000112863

Name Modeler Protein Id AA Range Protein Structure
AF-P97712-F1-model_v2 AlphaFold P97712 1-214 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697667
Promoter ID:EPDNEW_R8192
Type:single initiation site
Name:Csf3_1
Description:colony stimulating factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01086,616,743 - 86,616,803EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23349 BioCyc
Ensembl Genes ENSRNOG00000008525 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011509.4 UniProtKB/TrEMBL
  ENSRNOT00000112863.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  GCSF/MGF UniProtKB/TrEMBL
  IL-6/GCSF/MGF UniProtKB/TrEMBL
  IL6/GCSF/MGF_CS UniProtKB/TrEMBL
NCBI Gene 25610 ENTREZGENE
PANTHER GRANULOCYTE COLONY-STIMULATING FACTOR UniProtKB/TrEMBL
  PTHR10511 UniProtKB/TrEMBL
Pfam GCSF UniProtKB/TrEMBL
PhenoGen Csf3 PhenoGen
PIRSF IL6_MGF_GCSF UniProtKB/TrEMBL
PRINTS IL6GCSFMGF UniProtKB/TrEMBL
PROSITE INTERLEUKIN_6 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008525 RatGTEx
SMART IL6 UniProtKB/TrEMBL
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
TIGR TC226551
UniProt A0A8I6AAV9_RAT UniProtKB/TrEMBL
  A6HIT8 ENTREZGENE, UniProtKB/TrEMBL
  F7FGY7 ENTREZGENE, UniProtKB/TrEMBL
  P97712_RAT UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Csf3  colony stimulating factor 3  Csf3  colony stimulating factor 3 (granulocyte)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Csf3  colony stimulating factor 3 (granulocyte)    colony stimulating factor 3   Name updated 1299863 APPROVED
2002-11-06 Csf3  colony stimulating factor 3     Colony stimulating factor 3 (granulocyte)  Name updated 625702 APPROVED
2002-06-10 Csf3  Colony stimulating factor 3 (granulocyte)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_drugs used as a treatment for cyclic hematopoiesis, a severe recurrent neutropenia, in man and dogs 1298819
gene_process controls production and maintenance of neutrophils by acting on hematopoetic precursor cells 1298819