Dusp12 (dual specificity phosphatase 12) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Dusp12 (dual specificity phosphatase 12) Chinchilla lanigera
Analyze
Symbol: Dusp12
Name: dual specificity phosphatase 12
RGD ID: 9049295
Description: ENCODES a protein that exhibits kinase binding (ortholog); phosphatase activity (ortholog); phosphoprotein phosphatase activity (ortholog); INVOLVED IN positive regulation of glucokinase activity (ortholog); protein dephosphorylation (ortholog); ASSOCIATED WITH autoimmune interstitial lung, joint, and kidney disease (ortholog); Charcot-Marie-Tooth disease type 1 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity protein phosphatase 12
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546214,556,094 - 14,565,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546214,555,919 - 14,565,046 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dusp12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546214,556,094 - 14,565,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546214,555,919 - 14,565,046 (-)NCBIChiLan1.0ChiLan1.0
DUSP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,749,786 - 161,757,238 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,749,758 - 161,757,238 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,719,576 - 161,727,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,986,205 - 159,993,576 (+)NCBINCBI36Build 36hg18NCBI36
Build 341158,451,238 - 158,458,609NCBI
Celera1134,823,009 - 134,830,369 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,964,136 - 132,971,867 (+)NCBIHuRef
CHM1_11163,141,376 - 163,148,736 (+)NCBICHM1_1
T2T-CHM13v2.01161,094,105 - 161,101,566 (+)NCBIT2T-CHM13v2.0
Dusp12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,701,756 - 170,713,109 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,701,067 - 170,713,109 (-)EnsemblGRCm39 Ensembl
GRCm381170,874,187 - 170,885,540 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,873,498 - 170,885,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,804,319 - 172,815,671 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,710,863 - 172,722,215 (-)NCBIMGSCv36mm8
Celera1179,989,219 - 180,000,689 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map177.27NCBI
Dusp12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,654,914 - 85,666,431 (-)NCBIGRCr8
mRatBN7.21383,122,192 - 83,131,800 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,122,193 - 83,131,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,742,087 - 85,751,158 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,035,555 - 87,044,626 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,273,518 - 84,282,500 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,258,309 - 89,267,402 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,258,310 - 89,267,402 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,870,679 - 93,879,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,737,093 - 86,746,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11386,751,281 - 86,760,374 (-)NCBI
Celera1382,775,073 - 82,784,182 (-)NCBICelera
Cytogenetic Map13q24NCBI
DUSP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,029,384 - 88,037,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,697,674 - 87,706,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,161,774 - 137,169,503 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,959,867 - 140,968,821 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,959,867 - 140,968,821 (+)Ensemblpanpan1.1panPan2
DUSP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,912,543 - 20,921,137 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3820,912,546 - 20,921,125 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3820,964,899 - 20,973,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03820,995,914 - 21,004,157 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3820,995,394 - 21,004,163 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,967,831 - 20,975,985 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,320,983 - 21,328,971 (-)NCBIUNSW_CanFamBas_1.0
Dusp12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,636,761 - 7,643,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937131156,201 - 163,153 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937131156,175 - 163,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl488,809,565 - 88,818,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1488,811,565 - 88,818,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,827,001 - 96,834,199 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,316,668 - 2,319,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,353,582 - 1,363,032 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624826168,103 - 182,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624826167,966 - 182,844 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000015104   ⟹   ENSCLAP00000014945
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495546214,556,094 - 14,565,840 (-)Ensembl
RefSeq Acc Id: XM_005398286   ⟹   XP_005398343
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546214,555,919 - 14,565,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005398287   ⟹   XP_005398344
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546214,555,919 - 14,565,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521439   ⟹   XP_013376893
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546214,555,919 - 14,564,100 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005398343 (Get FASTA)   NCBI Sequence Viewer  
  XP_005398344 (Get FASTA)   NCBI Sequence Viewer  
  XP_013376893 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000014945
  ENSCLAP00000014945.1
Reference Protein Sequences
RefSeq Acc Id: XP_005398344   ⟸   XM_005398287
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005398343   ⟸   XM_005398286
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VHN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013376893   ⟸   XM_013521439
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000014945   ⟸   ENSCLAT00000015104
Protein Domains
C2H2-type   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010307 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015104 ENTREZGENE
  ENSCLAT00000015104.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  DUSP12 UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Dusp12 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
PIRSF DUSP12 UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART DSPc UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A8C2VHN1 ENTREZGENE, UniProtKB/TrEMBL