Macrod1 (mono-ADP ribosylhydrolase 1) - Rat Genome Database

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Gene: Macrod1 (mono-ADP ribosylhydrolase 1) Chinchilla lanigera
Analyze
Symbol: Macrod1
Name: mono-ADP ribosylhydrolase 1
RGD ID: 9022394
Description: ENCODES a protein that exhibits ADP-ribosylglutamate hydrolase activity (ortholog); deacetylase activity (ortholog); hydrolase activity, acting on glycosyl bonds (ortholog); INVOLVED IN DNA damage response (ortholog); purine nucleoside metabolic process (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH hereditary spastic paraplegia (ortholog); high grade glioma (ortholog); intellectual disability (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MACRO domain containing 1; O-acetyl-ADP-ribose deacetylase MACROD1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,906,521 - 21,046,345 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,906,406 - 21,046,448 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Macrod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,906,521 - 21,046,345 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,906,406 - 21,046,448 (+)NCBIChiLan1.0ChiLan1.0
MACROD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,998,558 - 64,166,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,998,558 - 64,166,113 (-)EnsemblGRCh38hg38GRCh38
GRCh371163,766,030 - 63,933,585 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,522,606 - 63,690,094 (-)NCBINCBI36Build 36hg18NCBI36
Celera1161,092,805 - 61,259,693 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,094,651 - 60,262,257 (-)NCBIHuRef
CHM1_11163,649,362 - 63,816,761 (-)NCBICHM1_1
T2T-CHM13v2.01163,988,261 - 64,156,074 (-)NCBIT2T-CHM13v2.0
Macrod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,034,065 - 7,175,427 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl197,034,178 - 7,175,422 (+)EnsemblGRCm39 Ensembl
GRCm38197,056,728 - 7,198,062 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,056,810 - 7,198,057 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,131,258 - 7,272,552 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,123,854 - 7,265,101 (+)NCBIMGSCv36mm8
Celera196,833,702 - 6,974,873 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.17NCBI
Macrod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,675,413 - 213,831,571 (+)NCBIGRCr8
mRatBN7.21204,246,238 - 204,387,027 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,246,166 - 204,389,716 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,596,116 - 212,736,945 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,691,528 - 219,832,257 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,382,579 - 212,523,308 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,310,916 - 222,451,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,310,920 - 222,451,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,301,706 - 229,442,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,730,907 - 209,871,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,889,336 - 210,029,821 (+)NCBI
Celera1201,779,880 - 201,919,740 (+)NCBICelera
Cytogenetic Map1q43NCBI
MACROD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,225,170 - 65,395,360 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,270,344 - 66,440,420 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,355,525 - 59,525,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,702,882 - 62,872,214 (-)NCBIpanpan1.1PanPan1.1panPan2
MACROD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,883,335 - 53,033,490 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,883,362 - 53,162,034 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,489,863 - 51,639,723 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,928,478 - 54,078,350 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,928,502 - 54,078,349 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,031,114 - 53,180,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,606,591 - 52,756,405 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,390,848 - 53,540,728 (+)NCBIUU_Cfam_GSD_1.0
Macrod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,576,259 - 8,712,495 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365995,018,770 - 5,154,491 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365995,018,636 - 5,154,844 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACROD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,939,125 - 8,088,595 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,939,125 - 8,087,656 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.227,054,730 - 7,204,542 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MACROD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,072,238 - 10,247,121 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl110,072,263 - 10,250,203 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,414,491 - 107,583,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Macrod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,135,881 - 22,278,329 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,135,972 - 22,278,429 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000024125   ⟹   ENSCLAP00000023899
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542220,906,521 - 21,046,345 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000024126   ⟹   ENSCLAP00000023900
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542220,906,521 - 21,046,146 (+)Ensembl
RefSeq Acc Id: XM_005384649   ⟹   XP_005384706
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542220,906,406 - 21,046,448 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005384651   ⟹   XP_005384708
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542220,906,409 - 21,046,448 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013513963   ⟹   XP_013369417
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542220,906,406 - 21,046,448 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005384706 (Get FASTA)   NCBI Sequence Viewer  
  XP_005384708 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000023899
  ENSCLAP00000023899.1
  ENSCLAP00000023900
  ENSCLAP00000023900.1
Reference Protein Sequences
RefSeq Acc Id: XP_005384706   ⟸   XM_005384649
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005384708   ⟸   XM_005384651
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YUC1 (UniProtKB/TrEMBL),   A0A8C2YUB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369417   ⟸   XM_013513963
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YUB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000023899   ⟸   ENSCLAT00000024125
RefSeq Acc Id: ENSCLAP00000023900   ⟸   ENSCLAT00000024126
Protein Domains
Macro


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016401 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000024125 ENTREZGENE
  ENSCLAT00000024125.1 UniProtKB/TrEMBL
  ENSCLAT00000024126 ENTREZGENE
  ENSCLAT00000024126.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.220.10 UniProtKB/TrEMBL
InterPro Macro_dom UniProtKB/TrEMBL
  Macro_dom-like UniProtKB/TrEMBL
NCBI Gene Macrod1 ENTREZGENE
PANTHER ADP-RIBOSE GLYCOHYDROLASE MACROD1 UniProtKB/TrEMBL
  GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED UniProtKB/TrEMBL
Pfam Macro UniProtKB/TrEMBL
PROSITE MACRO UniProtKB/TrEMBL
SMART A1pp UniProtKB/TrEMBL
Superfamily-SCOP SSF52949 UniProtKB/TrEMBL
UniProt A0A8C2YUB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YUC1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 Macrod1  mono-ADP ribosylhydrolase 1    MACRO domain containing 1  Symbol and/or name change 5135510 APPROVED