Polr1e (RNA polymerase I subunit E)

Gene: Polr1e (RNA polymerase I subunit E) Chinchilla lanigera

Analyze

Symbol:

Polr1e

Name:

RNA polymerase I subunit E

RGD ID:

8931053

Description:

ENCODES a protein that exhibits RNA polymerase I general transcription initiation factor binding (ortholog); INVOLVED IN nucleolar large rRNA transcription by RNA polymerase I (ortholog); RNA polymerase I preinitiation complex assembly (ortholog); transcription initiation at RNA polymerase I promoter (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); distal arthrogryposis type 1A (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ortholog); FOUND IN fibrillar center (ortholog); nucleolus (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA-directed RNA polymerase I subunit RPA49; polymerase (RNA) I polypeptide E, 53kDa

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	28,967,083 - 28,983,862 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	28,970,982 - 28,983,862 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

distal arthrogryposis type 1A (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

genetic disease (ISO)

primary ciliary dyskinesia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nucleolar large rRNA transcription by RNA polymerase I (ISO)

RNA polymerase I preinitiation complex assembly (ISO)

transcription initiation at RNA polymerase I promoter (ISO)

Cellular Component

fibrillar center (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

RNA polymerase I complex (ISO)

Molecular Function

protein binding (ISO)

RNA polymerase I general transcription initiation factor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase I transcription pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Polr1e
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	28,967,083 - 28,983,862 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	28,970,982 - 28,983,862 (-)	NCBI	ChiLan1.0	ChiLan1.0

POLR1E
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	37,485,948 - 37,503,697 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	37,485,948 - 37,503,697 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	37,485,945 - 37,503,694 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	37,475,945 - 37,493,693 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	37,419,179 - 37,436,922 (+)	NCBI		Celera
Cytogenetic Map	9	p13.2	NCBI
HuRef	9	37,437,994 - 37,455,737 (+)	NCBI		HuRef
CHM1_1	9	37,487,650 - 37,505,393 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	37,509,662 - 37,527,361 (+)	NCBI		T2T-CHM13v2.0

Polr1e
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	45,018,609 - 45,034,279 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	45,018,583 - 45,036,565 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	45,018,609 - 45,034,279 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	45,018,583 - 45,036,565 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	45,031,497 - 45,046,564 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	45,039,725 - 45,054,792 (+)	NCBI		MGSCv36	mm8
Celera	4	45,038,923 - 45,053,990 (+)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	23.67	NCBI

Polr1e
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	64,075,123 - 64,090,900 (+)	NCBI		GRCr8
mRatBN7.2	5	59,279,456 - 59,295,346 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	59,279,460 - 59,295,369 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	61,253,610 - 61,269,312 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	63,073,129 - 63,088,831 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	63,042,368 - 63,058,070 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	60,572,573 - 60,588,097 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	60,572,577 - 60,588,240 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	65,081,629 - 65,097,153 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	61,581,916 - 61,598,266 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	57,848,084 - 57,863,764 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

POLR1E
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	87,088,953 - 87,106,470 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	87,092,088 - 87,112,412 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	37,331,149 - 37,348,652 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	38,255,067 - 38,272,498 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	38,255,067 - 38,272,498 (+)	Ensembl	panpan1.1		panPan2

POLR1E
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	53,793,324 - 53,808,725 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	53,793,042 - 53,808,724 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	52,383,591 - 52,398,993 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	54,903,067 - 54,918,446 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	54,902,788 - 54,929,766 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	53,401,261 - 53,416,637 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	53,430,505 - 53,445,895 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	54,126,950 - 54,142,325 (+)	NCBI		UU_Cfam_GSD_1.0

Polr1e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	168,717,909 - 168,736,657 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	5,265,441 - 5,288,417 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	5,265,489 - 5,284,231 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLR1E
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	238,197,684 - 238,220,524 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	238,197,659 - 238,219,475 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	266,106,665 - 266,126,203 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLR1E
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	43,082,707 - 43,101,416 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	43,083,197 - 43,108,367 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	40,148,685 - 40,169,530 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Polr1e
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624930	1,104,311 - 1,122,077 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624930	1,104,387 - 1,120,580 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005382878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01020481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01224045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000018696 ⟹ ENSCLAP00000018514

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955419	28,967,083 - 28,983,862 (-)	Ensembl

RefSeq Acc Id:

XM_005382878 ⟹ XP_005382935

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955419	28,970,982 - 28,983,862 (-)	NCBI

Sequence:

show sequence

GGCGGGGCCGCGCTACGCATGCTGTGGGCAGGACCCGACGAGGCCACGCCCCTTCCGGCTCGCG
GTACTTGCTGGGACCCCTCGTGTTAGCGGACGAGCTGGTGGTTGCGCTCTCCTTTTATGTGCTG
GGCGGAGGGGCAGTCGAAATGGCGGCAGAGATGTTACCCAGCGCGAGGTGGCAATACTGTGGAG
AGCCGGACGAGAGCCAGAGAGCTGTACTGGTTCAGTTCTCCAACGGGAAGCTGCAGGATCCAGG
CAGTCTGCGCTTCACTTTGTACAACAGCACTGACTCCACAAACCCCAGGAAGAGGAGTCAGCGG
ATCCTGGCAGCTGAAACAGACAGACTTTCCTATGTTGGAAATAACTTTGGGACTGGAGCCCTCA
AATGTAACACTCTGTGCAGACACTTTGTGGGAATTTTGAACAAGACCTCTGGCCAAATGGAAGT
ATATGACGCTGAATTGTTTAACATGCAGCCACTGTTTGCAGATGAATCAATTGAGAGTGAACCC
ACATCGGAAAATCAGACCAAAACTTTCAGAGAAAAGATGGATTCTTGCATTGAGGCCTTTGGTA
CCACCAAGCAGAAACGAGCTCTGAACTCCAGGAGAATGAACAAAGTTGGCAGTGAATCTTTGAA
TCTTGCAGTAGCTAAAGCTGCAGAGGAGATCATTGATACAAAGGGTGTGGAAGCACTGGTCAGT
GACGCCATCCAGGACGATTTGCAAGATGACTCCCTCTACCTTCCTCCCTGCTATGCTGATGCAG
CCAAGCCCGAAGAAGTGTATAAATTTGAAGATATTCTGTCCCCTGAGGAGTATGATGCTCTTGA
GGGCCCATCTGAAGCTTTCAGGAAGGTCACATCAGAAGAGATATTGAAGATGATTGAAGAGAAC
AGCCACTGCTTCTTTGTCATAGAAGCATTGAAGTCTTTGCCATCAAACGAGGAGAGCAGAGATC
GCCAGGCCCGGTGTATATGGTTTCTAGACACCCTCATCAAATTTCGAGCTCAGAAAGTGATAAA
GCGGAAAAGTGCCCTGGGACCTGGAATCCCCCACATCATCAACACCAAACTGCTGAAGCACTTT
ACCTGCTTGACTTACAACAATGGCAGTTTACGGAACTTAATTTCGAATTCTATGAAAGCAAAGA
TCACCGCATATGTGATCATACTTGCCTTACACATAAATGACTTCCAGATTGACCTGACAGTGTT
ACAGCGAGACTTGAAACTCAGTGAGAAAAGGATGATTGAGATAGCGAAAGCCATGAGGTTGAAG
ATCTCTAAAAGAAAGGTGTCACTGGCACCTGGCAGGGAAGAGGATCATAAGCTGGGCACTCTGT
CTATCCCACTGCCTCCAGCTCAGAACTCAAACCAGCAGTCAAAGCGGAGGAAGATGTAACTAGA
TGTATGCTTTCCAGGCAGGCATTTTGGTCCCCTCATAGCCACTGCCTGAAAAGAAAATGAAAGC
AGCCTTGCCTCTTCAGGAGTGTATAAAGGCAGAAGCCAGCATCCAAATCATGCCTGTTTTATGT
AGAAATATAAAGTGATGGCCAGACTGGACTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005382935	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000018514
	ENSCLAP00000018514.1

RefSeq Acc Id:

XP_005382935 ⟸ XM_005382878

- UniProtKB:

A0A8C2VT85 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAEMLPSARWQYCGEPDESQRAVLVQFSNGKLQDPGSLRFTLYNSTDSTNPRKRSQRILAAET
DRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFADESIESEPTSENQT
KTFREKMDSCIEAFGTTKQKRALNSRRMNKVGSESLNLAVAKAAEEIIDTKGVEALVSDAIQDD
LQDDSLYLPPCYADAAKPEEVYKFEDILSPEEYDALEGPSEAFRKVTSEEILKMIEENSHCFFV
IEALKSLPSNEESRDRQARCIWFLDTLIKFRAQKVIKRKSALGPGIPHIINTKLLKHFTCLTYN
NGSLRNLISNSMKAKITAYVIILALHINDFQIDLTVLQRDLKLSEKRMIEIAKAMRLKISKRKV
SLAPGREEDHKLGTLSIPLPPAQNSNQQSKRRKM

hide sequence

RefSeq Acc Id:

ENSCLAP00000018514 ⟸ ENSCLAT00000018696

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000012701	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000018696	ENTREZGENE
	ENSCLAT00000018696.1	UniProtKB/TrEMBL
InterPro	RNA_pol-assoc_fac_A49-like	UniProtKB/TrEMBL
NCBI Gene	Polr1e	ENTREZGENE
PANTHER	DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49	UniProtKB/TrEMBL
	PTHR14440	UniProtKB/TrEMBL
Pfam	RNA_pol_I_A49	UniProtKB/TrEMBL
UniProt	A0A8C2VT85	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-26	Polr1e	RNA polymerase I subunit E		polymerase (RNA) I polypeptide E, 53kDa	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

RGD Manual Annotations