Nr1h2 (nuclear receptor subfamily 1 group H member 2) - Rat Genome Database

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Pathways
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Gene: Nr1h2 (nuclear receptor subfamily 1 group H member 2) Chinchilla lanigera
Analyze
Symbol: Nr1h2
Name: nuclear receptor subfamily 1 group H member 2
RGD ID: 8887353
Description: ENCODES a protein that exhibits apolipoprotein A-I receptor binding (ortholog); ATPase binding (ortholog); chromatin DNA binding (ortholog); INVOLVED IN cellular lipid metabolic process (ortholog); cholesterol homeostasis (ortholog); lipid homeostasis (ortholog); ASSOCIATED WITH atherosclerosis (ortholog); cholestasis (ortholog); Experimental Arthritis (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear receptor subfamily 1, group H, member 2; oxysterols receptor LXR-beta
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559730,670 - 737,505 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955559731,630 - 736,973 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular lipid metabolic process  (ISO)
cholesterol homeostasis  (ISO)
lipid homeostasis  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of pinocytosis  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of response to endoplasmic reticulum stress  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
phosphatidylcholine acyl-chain remodeling  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cholesterol transport  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of high-density lipoprotein particle assembly  (ISO)
positive regulation of lipid storage  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of pancreatic juice secretion  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of secretion of lysosomal enzymes  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to nutrient levels  (ISO)
retinoic acid receptor signaling pathway  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nr1h2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559730,670 - 737,505 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955559731,630 - 736,973 (-)NCBIChiLan1.0ChiLan1.0
NR1H2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,376,457 - 50,383,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,329,653 - 50,383,388 (+)EnsemblGRCh38hg38GRCh38
GRCh371950,879,714 - 50,886,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,571,497 - 55,578,079 (+)NCBINCBI36Build 36hg18NCBI36
Build 341955,571,514 - 55,578,048NCBI
Celera1947,929,924 - 47,936,510 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,217,814 - 47,224,423 (+)NCBIHuRef
CHM1_11950,881,453 - 50,888,062 (+)NCBICHM1_1
T2T-CHM13v2.01953,464,005 - 53,470,940 (+)NCBIT2T-CHM13v2.0
Nr1h2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,199,040 - 44,204,928 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,199,040 - 44,203,375 (-)EnsemblGRCm39 Ensembl
GRCm38744,549,616 - 44,553,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,549,616 - 44,553,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv37751,805,002 - 51,809,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,417,674 - 44,421,965 (-)NCBIMGSCv36mm8
Celera739,999,761 - 40,004,052 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.83NCBI
Nr1h2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,178,483 - 104,183,863 (-)NCBIGRCr8
mRatBN7.2195,041,967 - 95,047,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,041,967 - 95,047,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,427,372 - 100,432,752 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,900,016 - 108,905,396 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,190,437 - 102,195,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,554,577 - 100,559,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,554,544 - 100,559,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,619,964 - 101,625,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,027,197 - 95,032,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,105,321 - 95,110,627 (-)NCBI
Celera189,304,444 - 89,309,763 (-)NCBICelera
Cytogenetic Map1q22NCBI
NR1H2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,442,021 - 56,448,701 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,363,472 - 58,370,113 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,340,077 - 47,346,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,243,124 - 56,250,024 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,243,124 - 56,250,024 (+)Ensemblpanpan1.1panPan2
NR1H2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,332,691 - 106,339,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,332,798 - 106,339,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,905,786 - 105,912,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,843,783 - 106,850,258 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,843,781 - 106,850,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,515,887 - 106,522,355 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,157,420 - 106,163,895 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,998,070 - 107,004,546 (-)NCBIUU_Cfam_GSD_1.0
Nr1h2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,347,505 - 22,353,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889223,101 - 229,990 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889223,137 - 229,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR1H2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,239,500 - 55,245,456 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,238,536 - 55,245,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,087,383 - 51,094,318 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR1H2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,438,428 - 43,445,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,437,950 - 43,446,063 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607323,425,677 - 23,432,503 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr1h2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,132,904 - 4,140,896 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,136,052 - 4,141,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000006486   ⟹   ENSCLAP00000006380
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955559730,670 - 737,505 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000006487   ⟹   ENSCLAP00000006381
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955559732,013 - 736,138 (-)Ensembl
RefSeq Acc Id: XM_013509031   ⟹   XP_013364485
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955559731,630 - 736,973 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013509032   ⟹   XP_013364486
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955559732,013 - 736,973 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013364485 (Get FASTA)   NCBI Sequence Viewer  
  XP_013364486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000006380.1
  ENSCLAP00000006381
  ENSCLAP00000006381.1
Reference Protein Sequences
RefSeq Acc Id: XP_013364485   ⟸   XM_013509031
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UWD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364486   ⟸   XM_013509032
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UWD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000006381   ⟸   ENSCLAT00000006487
RefSeq Acc Id: ENSCLAP00000006380   ⟸   ENSCLAT00000006486
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004511 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000006486.1 UniProtKB/TrEMBL
  ENSCLAT00000006487 ENTREZGENE
  ENSCLAT00000006487.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro Liver_X_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Nr1h2 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  OXYSTEROLS RECEPTOR LXR-BETA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS LIVERXRECPTR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A8C2UVG1_CHILA UniProtKB/TrEMBL
  A0A8C2UWD2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nr1h2  nuclear receptor subfamily 1 group H member 2    nuclear receptor subfamily 1, group H, member 2  Symbol and/or name change 5135510 APPROVED