Scn8a (sodium voltage-gated channel alpha subunit 8) - Rat Genome Database

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Gene: Scn8a (sodium voltage-gated channel alpha subunit 8) Chinchilla lanigera
Analyze
Symbol: Scn8a
Name: sodium voltage-gated channel alpha subunit 8
RGD ID: 8807813
Description: ENCODES a protein that exhibits sodium ion binding (ortholog); voltage-gated sodium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); locomotory behavior (ortholog); muscle organ development (ortholog); ASSOCIATED WITH Ataxia (ortholog); autistic disorder (ortholog); benign familial infantile seizures 5 (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium channel protein type 8 subunit alpha; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,086,178 - 2,195,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Scn8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,086,178 - 2,195,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBIChiLan1.0ChiLan1.0
SCN8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,591,233 - 51,812,864 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,590,266 - 51,812,864 (+)EnsemblGRCh38hg38GRCh38
GRCh371251,985,017 - 52,206,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,271,287 - 50,488,574 (+)NCBINCBI36Build 36hg18NCBI36
Build 341250,271,286 - 50,488,365NCBI
Celera1250,787,152 - 51,004,408 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,089,349 - 49,239,456 (+)NCBIHuRef
CHM1_11251,951,468 - 52,173,106 (+)NCBICHM1_1
T2T-CHM13v2.01251,554,795 - 51,776,384 (+)NCBIT2T-CHM13v2.0
Scn8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,766,600 - 100,943,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,767,739 - 100,943,819 (+)EnsemblGRCm39 Ensembl
GRCm3815100,869,863 - 101,045,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,869,858 - 101,045,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715100,701,114 - 100,876,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,764,359 - 100,868,722 (+)NCBIMGSCv36mm8
Celera15103,017,992 - 103,192,774 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.39NCBI
Scn8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,860,901 - 134,034,809 (+)NCBIGRCr8
mRatBN7.27131,982,152 - 132,156,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,982,480 - 132,151,292 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,784,484 - 133,952,871 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,014,006 - 136,182,387 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,924,362 - 136,093,194 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,575,629 - 142,683,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,575,672 - 142,684,114 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,377,038 - 140,485,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,686,180 - 139,794,282 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,762,616 - 139,870,727 (+)NCBI
Celera7128,450,559 - 128,618,862 (+)NCBICelera
Cytogenetic Map7q36NCBI
SCN8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,385,627 - 42,604,490 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,382,391 - 42,601,856 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,950,057 - 37,172,235 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,725,471 - 38,057,190 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,730,900 - 37,876,357 (-)Ensemblpanpan1.1panPan2
SCN8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,174,257 - 3,348,349 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,176,013 - 3,296,482 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,959,130 - 43,080,423 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,170,259 - 3,346,792 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,172,854 - 3,345,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,189,615 - 3,363,479 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,173,058 - 3,350,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,304,862 - 43,478,762 (+)NCBIUU_Cfam_GSD_1.0
Scn8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,880,790 - 64,000,520 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,164,262 - 9,279,688 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,164,310 - 9,281,795 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl516,977,700 - 17,169,543 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1516,977,468 - 17,173,831 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,560,130 - 17,767,953 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCN8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,770,513 - 47,983,843 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,838,358 - 47,978,399 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037198,106,707 - 198,322,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816499,179 - 631,936 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816498,737 - 631,850 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000002617   ⟹   ENSCLAP00000002564
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555472,086,178 - 2,195,971 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000002618   ⟹   ENSCLAP00000002565
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555472,086,215 - 2,195,971 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000002619   ⟹   ENSCLAP00000002566
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555472,086,215 - 2,195,971 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000002620   ⟹   ENSCLAP00000002567
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555472,086,263 - 2,195,971 (+)Ensembl
RefSeq Acc Id: XM_005411910   ⟹   XP_005411967
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005411911   ⟹   XP_005411968
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005411914   ⟹   XP_005411971
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005411915   ⟹   XP_005411972
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555472,109,450 - 2,201,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005411916   ⟹   XP_005411973
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555472,116,425 - 2,201,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013508490   ⟹   XP_013363944
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001232232
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001232233
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005411967   ⟸   XM_005411910
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YJ62 (UniProtKB/TrEMBL),   A0A8C2UMX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005411971   ⟸   XM_005411914
- Peptide Label: isoform X4
- UniProtKB: A0A8C2YJ67 (UniProtKB/TrEMBL),   A0A8C2UMX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005411968   ⟸   XM_005411911
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UN58 (UniProtKB/TrEMBL),   A0A8C2UMX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005411972   ⟸   XM_005411915
- Peptide Label: isoform X5
- UniProtKB: A0A8C2UMX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005411973   ⟸   XM_005411916
- Peptide Label: isoform X6
- UniProtKB: A0A8C2UMX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013363944   ⟸   XM_013508490
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UMX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000002565   ⟸   ENSCLAT00000002618
RefSeq Acc Id: ENSCLAP00000002564   ⟸   ENSCLAT00000002617
RefSeq Acc Id: ENSCLAP00000002566   ⟸   ENSCLAT00000002619
RefSeq Acc Id: ENSCLAP00000002567   ⟸   ENSCLAT00000002620
Protein Domains
Ion transport   Sodium ion transport-associated   Voltage-gated Na+ ion channel cytoplasmic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001856 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002617 ENTREZGENE
  ENSCLAT00000002617.1 UniProtKB/TrEMBL
  ENSCLAT00000002618 ENTREZGENE
  ENSCLAT00000002618.1 UniProtKB/TrEMBL
  ENSCLAT00000002619 ENTREZGENE
  ENSCLAT00000002619.1 UniProtKB/TrEMBL
  ENSCLAT00000002620.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  iswi atpase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Na_channel_a8su UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Scn8a ENTREZGENE
PANTHER PTHR10037 UniProtKB/TrEMBL
  SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
PRINTS NACHANNEL UniProtKB/TrEMBL
  NACHANNEL8 UniProtKB/TrEMBL
PROSITE PS50096 UniProtKB/TrEMBL
SMART SM00015 UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C2UMX4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UN58 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YJ62 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YJ67 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Scn8a  sodium voltage-gated channel alpha subunit 8    sodium channel, voltage gated, type VIII alpha subunit  Symbol and/or name change 5135510 APPROVED
2015-08-25 Scn8a  sodium channel, voltage gated, type VIII alpha subunit    sodium channel, voltage gated, type VIII, alpha subunit  Symbol and/or name change 5135510 APPROVED