Gene: Scn8a (sodium voltage-gated channel alpha subunit 8) Rattus norvegicus
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Symbol: Scn8a
Name: sodium voltage-gated channel alpha subunit 8
Description: ENCODES a protein that exhibits sodium ion binding; voltage-gated sodium channel activity; INVOLVED IN myelination; neuronal action potential; peripheral nervous system development; ASSOCIATED WITH congestive heart failure; Heart Failure; Ataxia (ortholog); FOUND IN axon initial segment; integral component of membrane; node of Ranvier; INTERACTS WITH (+)-pilocarpine; (+)-trans-(S)-allethrin; 6-propyl-2-thiouracil
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Na+ channel; naCh6; peripheral nerve protein type 4; PN4; sodium channel 6; sodium channel protein type 8 subunit alpha; sodium channel protein type VIII subunit alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha; sodium channel, voltage-gated, type VIII, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.6
Orthologs:
Homo sapiens (human) : SCN8A (sodium voltage-gated channel alpha subunit 8)  HGNC  AGR
Mus musculus (house mouse) : Scn8a (sodium channel, voltage-gated, type VIII, alpha)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Scn8a (sodium voltage-gated channel alpha subunit 8)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN8A (sodium voltage-gated channel alpha subunit 8)
Canis lupus familiaris (dog) : SCN8A (sodium voltage-gated channel alpha subunit 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn8a (sodium voltage-gated channel alpha subunit 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07142,575,629 - 142,683,659 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07140,377,038 - 140,485,139 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.47139,686,180 - 139,794,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,762,616 - 139,870,727 (+)NCBI
Celera7128,450,559 - 128,618,862 (+)NCBI
Cytogenetic Map7q36NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Scn8a
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 3638
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-10
Status: ACTIVE