Gene: Scn8a (sodium voltage-gated channel alpha subunit 8) Rattus norvegicus
Symbol: Scn8a
Name: sodium voltage-gated channel alpha subunit 8
Description: ENCODES a protein that exhibits sodium ion binding; voltage-gated sodium channel activity; INVOLVED IN myelination; neuronal action potential; peripheral nervous system development; ASSOCIATED WITH Heart Failure; Cognitive Impairment with or without Cerebellar Ataxia (ortholog); Developmental Disabilities (ortholog); FOUND IN axon initial segment; integral component of membrane; node of Ranvier; INTERACTS WITH (+)-pilocarpine; (+)-trans-(S)-allethrin; 6-propyl-2-thiouracil
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Na+ channel; naCh6; peripheral nerve protein type 4; PN4; sodium channel 6; sodium channel protein type 8 subunit alpha; sodium channel protein type VIII subunit alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha; sodium channel, voltage-gated, type VIII, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.6
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07142,575,629 - 142,683,659 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07140,377,038 - 140,485,139 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.47139,686,180 - 139,794,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,762,616 - 139,870,727 (+)NCBI
Celera7128,450,559 - 128,618,862 (+)NCBI
Cytogenetic Map7q36NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Scn8a
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 3638
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-07-05
Status: ACTIVE