Mmp7 (matrix metallopeptidase 7) - Rat Genome Database

Name: Mmp7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Mmp7 (matrix metallopeptidase 7) Chinchilla lanigera

Analyze

Symbol:

Mmp7

Name:

matrix metallopeptidase 7

RGD ID:

8767773

Description:

ENCODES a protein that exhibits endopeptidase activity (ortholog); heparin binding (ortholog); metallopeptidase activity (ortholog); INVOLVED IN antibacterial peptide biosynthetic process (ortholog); antibacterial peptide secretion (ortholog); cellular response to mechanical stimulus (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); asphyxiating thoracic dystrophy (ortholog); ataxia telangiectasia (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

matrilysin; matrix metallopeptidase 7 (matrilysin, uterine)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	5,778,502 - 5,792,445 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	5,780,772 - 5,792,485 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

asphyxiating thoracic dystrophy (ISO)

ataxia telangiectasia (ISO)

bladder neck obstruction (ISO)

Burns (ISO)

Cardiac Fibrosis (ISO)

Chronic Allograft Nephropathy (ISO)

Colonic Neoplasms (ISO)

coronary restenosis (ISO)

endometrial cancer (ISO)

endometrial hyperplasia (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Autoimmune Neuritis (ISO)

Experimental Mammary Neoplasms (ISO)

genetic disease (ISO)

glioblastoma (ISO)

Hearing Loss, Noise-Induced (ISO)

hypertension (ISO)

intellectual disability (ISO)

Intimal Hyperplasia (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

myocardial infarction (ISO)

Osteolysis (ISO)

Peripheral Nerve Injuries (ISO)

pre-malignant neoplasm (ISO)

prostate cancer (ISO)

prostate carcinoma (ISO)

pulmonary tuberculosis (ISO)

Recurrence (ISO)

renal hypertension (ISO)

Spontaneous Abortions (ISO)

Stomach Neoplasms (ISO)

ureteral obstruction (ISO)

Ventilator-Induced Lung Injury (ISO)

Wounds and Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibacterial peptide biosynthetic process (ISO)

antibacterial peptide secretion (ISO)

cellular response to mechanical stimulus (ISO)

defense response to bacterium (ISO)

defense response to Gram-negative bacterium (ISO)

defense response to Gram-positive bacterium (ISO)

estrous cycle (ISO)

maternal process involved in female pregnancy (ISO)

membrane protein ectodomain proteolysis (ISO)

membrane protein intracellular domain proteolysis (ISO)

positive regulation of cell migration (ISO)

proteolysis (ISO)

regulation of cell population proliferation (ISO)

response to nutrient levels (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

cell surface (ISO)

extracellular space (ISO)

Molecular Function

endopeptidase activity (ISO)

heparin binding (ISO)

metallopeptidase activity (ISO)

peptidase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

syndecan signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Mmp7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	5,778,502 - 5,792,445 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	5,780,772 - 5,792,485 (-)	NCBI	ChiLan1.0	ChiLan1.0

MMP7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	102,520,508 - 102,530,747 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	102,520,508 - 102,530,750 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	102,391,239 - 102,401,478 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	101,896,449 - 101,906,688 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	101,896,448 - 101,906,688	NCBI
Celera	11	99,552,782 - 99,563,021 (-)	NCBI		Celera
Cytogenetic Map	11	q22.2	NCBI
HuRef	11	98,318,241 - 98,328,480 (-)	NCBI		HuRef
CHM1_1	11	102,274,287 - 102,284,528 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	102,522,678 - 102,532,920 (-)	NCBI		T2T-CHM13v2.0

Mmp7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	7,692,095 - 7,699,587 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	7,692,091 - 7,699,586 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	7,692,090 - 7,699,585 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	7,692,090 - 7,699,585 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	7,692,111 - 7,699,416 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	7,692,097 - 7,699,255 (+)	NCBI		MGSCv36	mm8
Celera	9	5,082,790 - 5,090,191 (+)	NCBI		Celera
Cytogenetic Map	9	A1	NCBI
cM Map	9	2.46	NCBI

Mmp7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	13,133,043 - 13,140,761 (+)	NCBI		GRCr8
mRatBN7.2	8	4,848,186 - 4,855,908 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	4,848,186 - 4,855,902 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	8,808,955 - 8,816,704 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	7,106,740 - 7,114,491 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	5,107,859 - 5,115,573 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	5,893,253 - 5,900,965 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	5,893,249 - 5,901,049 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	5,895,393 - 5,903,105 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	4,526,018 - 4,533,730 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	4,526,033 - 4,533,729 (+)	NCBI
Celera	8	6,407,543 - 6,415,255 (+)	NCBI		Celera
Cytogenetic Map	8	q11	NCBI

MMP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	103,319,695 - 103,329,920 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	104,408,059 - 104,418,283 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	97,467,037 - 97,477,305 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	100,960,107 - 100,970,355 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	100,960,032 - 100,971,099 (-)	Ensembl	panpan1.1		panPan2

MMP7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	29,187,902 - 29,196,157 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	29,187,851 - 29,196,153 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	29,135,576 - 29,143,842 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	29,239,121 - 29,247,375 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	29,238,932 - 29,247,371 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	29,273,927 - 29,282,176 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	29,153,310 - 29,161,571 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	29,328,802 - 29,337,062 (+)	NCBI		UU_Cfam_GSD_1.0

Mmp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	86,138,756 - 86,148,072 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936551	5,388,459 - 5,395,071 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936551	5,388,456 - 5,395,071 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MMP7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	33,214,594 - 33,225,080 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	33,214,590 - 33,225,080 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	37,133,037 - 37,143,432 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MMP7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	93,889,189 - 93,901,077 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	93,889,198 - 93,899,587 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	31,959,442 - 31,969,839 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mmp7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624878	345,038 - 361,652 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624878	345,038 - 364,986 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005377982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01012657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01012658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01007320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000022598 ⟹ ENSCLAP00000022393

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955412	5,778,502 - 5,792,445 (-)	Ensembl

RefSeq Acc Id:

XM_005377982 ⟹ XP_005378039

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955412	5,780,772 - 5,792,485 (-)	NCBI

Sequence:

show sequence

GCATTAAACTTCAAACCAATCATAGGCCTGAGAACAGCTGATGGTAGCTATGCTGCTCACCCTG
CTGTGGGCCGTGTGTCTGCTGCCCAGCTGCCTGGCCCTGCCGCTGCCCCCGGAGGCGAGAGACA
CGAGCGACCTGCAGTGGGCAAAGGCACAGGACTACCTCAAGAGATTTTATCTCCTTGACTCAGA
AAGAAAGGATGCCAACAGTTTCAAAGACAAACTCAAGGAAATGGAGAAGTTCTTCCATCTACCT
ATAACAGGGAAGTTAAACCCTCGCATCACAGCAATAATGCAGAAGCCCAGATGTGGAGTGCCAG
ACGTTGCAGAATATTCACTATTTGCAGAAAAGCCAAAGTGGACTTCCACAGTTGTCACTTACAG
AATTGTATCCTATACTCCAGACTTACCACAGAGCAGAGTGGATGAAATAGTGGCAAAAGCGTTA
AGCCTGTGGAGCGAGGAGATCCCACTGAGCTTCAGGAGAATTCGGTTTGGAACAGCTGATATAG
AGATTGGCTTTGCCAGAGGAGCTCACGGTGACTTCCACCCATTTGACGGACCAGGAAACGTTCT
GGCTCATGCCTTCCCACCTGGGCCAGGCTTAGGAGGAGATGCTCACTTCGACAAGGATGAACTC
TGGACCGACGGCAGCAGACTAGGAATTAACTTCCTGTATGTGGCAACTCATGAACTTGGCCATT
CTCTGGGCCTGAGTCACTCCGCCAACCCTGACGCCGTGATGTACCCAACATACGGAAACGGAGA
CTTTCGAAGCTTCAGACTTGCGTGGGATGACATTGAAGGCATTCAGGAATTATACGGAAAGAAA
AGTAATGAAAGAAAGAGATAGAAACTTCAGGGTGAATATCCATTCATTCATTCATTCACTGGAT
TCTGTATCAGCATCACCCAGACGGAATTAACAACCGCTCCTCCTCCTGCGCTCCACTCAGAATT
TATTTCACTCTTGCTCGGGTGTGGCTGCTTTGGCCACGTTTCTCCTTCTCTGGAGGATAAATTC
CTTTATGACGTGACTTGGTCTTACTCACGTATAATTGTCTTCAGGCAACATCAGTTGGTAGATG
TCAATAAATGTCACATACAAAAATAAGTAAAGCTCTTATTTCATGGTGAGATTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005378039	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022393
	ENSCLAP00000022393.1

RefSeq Acc Id:

XP_005378039 ⟸ XM_005377982

- UniProtKB:

A0A8C2W361 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVAMLLTLLWAVCLLPSCLALPLPPEARDTSDLQWAKAQDYLKRFYLLDSERKDANSFKDKLKE
MEKFFHLPITGKLNPRITAIMQKPRCGVPDVAEYSLFAEKPKWTSTVVTYRIVSYTPDLPQSRV
DEIVAKALSLWSEEIPLSFRRIRFGTADIEIGFARGAHGDFHPFDGPGNVLAHAFPPGPGLGGD
AHFDKDELWTDGSRLGINFLYVATHELGHSLGLSHSANPDAVMYPTYGNGDFRSFRLAWDDIEG
IQELYGKKSNERKR

hide sequence

RefSeq Acc Id:

ENSCLAP00000022393 ⟸ ENSCLAT00000022598

Protein Domains

Peptidase metallopeptidase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015356	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022598	ENTREZGENE
	ENSCLAT00000022598.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.390.10	UniProtKB/TrEMBL
InterPro	M10A_MMP	UniProtKB/TrEMBL
	MetalloPept_cat_dom_sf	UniProtKB/TrEMBL
	Pept_M10_metallopeptidase	UniProtKB/TrEMBL
	Pept_M10A	UniProtKB/TrEMBL
	Pept_M10A_Zn_BS	UniProtKB/TrEMBL
	Peptidase_Metallo	UniProtKB/TrEMBL
	Peptidoglycan-bd-like	UniProtKB/TrEMBL
	PGBD-like_sf	UniProtKB/TrEMBL
NCBI Gene	Mmp7	ENTREZGENE
PANTHER	MATRIX METALLOPROTEINASE	UniProtKB/TrEMBL
	PTHR10201:SF143	UniProtKB/TrEMBL
Pfam	Peptidase_M10	UniProtKB/TrEMBL
	PG_binding_1	UniProtKB/TrEMBL
PRINTS	MATRIXIN	UniProtKB/TrEMBL
PROSITE	CYSTEINE_SWITCH	UniProtKB/TrEMBL
SMART	ZnMc	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
	SSF47090	UniProtKB/TrEMBL
UniProt	A0A8C2W361	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	Mmp7	matrix metallopeptidase 7		matrix metallopeptidase 7 (matrilysin, uterine)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)