MMP7 (matrix metallopeptidase 7) - Rat Genome Database

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Gene: MMP7 (matrix metallopeptidase 7) Canis lupus familiaris
Analyze
Symbol: MMP7
Name: matrix metallopeptidase 7
RGD ID: 12216168
Description: ENCODES a protein that exhibits heparin binding (ortholog); INVOLVED IN antibacterial peptide biosynthetic process (ortholog); antibacterial peptide secretion (ortholog); cellular response to mechanical stimulus (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); asphyxiating thoracic dystrophy (ortholog); ataxia telangiectasia (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: matrilysin; matrix metallopeptidase 7 (matrilysin, uterine)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,187,902 - 29,196,157 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,187,851 - 29,196,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,135,576 - 29,143,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,239,121 - 29,247,375 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,238,932 - 29,247,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,273,927 - 29,282,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,153,310 - 29,161,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,328,802 - 29,337,062 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15782307   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MMP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,187,902 - 29,196,157 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,187,851 - 29,196,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,135,576 - 29,143,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,239,121 - 29,247,375 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,238,932 - 29,247,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,273,927 - 29,282,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,153,310 - 29,161,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,328,802 - 29,337,062 (+)NCBIUU_Cfam_GSD_1.0
MMP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,520,508 - 102,530,747 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,520,508 - 102,530,750 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,391,239 - 102,401,478 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,896,449 - 101,906,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411101,896,448 - 101,906,688NCBI
Celera1199,552,782 - 99,563,021 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,318,241 - 98,328,480 (-)NCBIHuRef
CHM1_111102,274,287 - 102,284,528 (-)NCBICHM1_1
T2T-CHM13v2.011102,522,678 - 102,532,920 (-)NCBIT2T-CHM13v2.0
Mmp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,692,095 - 7,699,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,692,091 - 7,699,586 (+)EnsemblGRCm39 Ensembl
GRCm3897,692,090 - 7,699,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,692,090 - 7,699,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,692,111 - 7,699,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,692,097 - 7,699,255 (+)NCBIMGSCv36mm8
Celera95,082,790 - 5,090,191 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,133,043 - 13,140,761 (+)NCBIGRCr8
mRatBN7.284,848,186 - 4,855,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,848,186 - 4,855,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,808,955 - 8,816,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,106,740 - 7,114,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,107,859 - 5,115,573 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,893,253 - 5,900,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,893,249 - 5,901,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,895,393 - 5,903,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,526,018 - 4,533,730 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,526,033 - 4,533,729 (+)NCBI
Celera86,407,543 - 6,415,255 (+)NCBICelera
Cytogenetic Map8q11NCBI
Mmp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,778,502 - 5,792,445 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,780,772 - 5,792,485 (-)NCBIChiLan1.0ChiLan1.0
MMP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,319,695 - 103,329,920 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,408,059 - 104,418,283 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,467,037 - 97,477,305 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,960,107 - 100,970,355 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,960,032 - 100,971,099 (-)Ensemblpanpan1.1panPan2
Mmp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,138,756 - 86,148,072 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,388,459 - 5,395,071 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,388,456 - 5,395,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,214,594 - 33,225,080 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,214,590 - 33,225,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,133,037 - 37,143,432 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,889,189 - 93,901,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,889,198 - 93,899,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,959,442 - 31,969,839 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878345,038 - 361,652 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878345,038 - 364,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MMP7
99 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 6 2
Low 1 1 1 3
Below cutoff 3 1 8 4 4 2 1 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023937   ⟹   ENSCAFP00000022222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl529,187,851 - 29,194,815 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000035228   ⟹   ENSCAFP00000030464
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl529,187,851 - 29,196,153 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845001697   ⟹   ENSCAFP00845001341
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl529,238,932 - 29,247,371 (+)Ensembl
RefSeq Acc Id: NM_001242726   ⟹   NP_001229655
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1529,187,902 - 29,196,157 (+)NCBI
Dog10K_Boxer_Tasha529,135,576 - 29,143,842 (+)NCBI
ROS_Cfam_1.0529,239,121 - 29,247,375 (+)NCBI
UMICH_Zoey_3.1529,273,927 - 29,282,176 (+)NCBI
UNSW_CanFamBas_1.0529,153,310 - 29,161,571 (+)NCBI
UU_Cfam_GSD_1.0529,328,802 - 29,337,062 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001229655 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEA40854 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000030464.2
  ENSCAFP00030023234.1
  ENSCAFP00040033775.1
  ENSCAFP00845001341
  ENSCAFP00845001341.1
Reference Protein Sequences
RefSeq Acc Id: NP_001229655   ⟸   NM_001242726
- Peptide Label: precursor
- UniProtKB: F2YQ11 (UniProtKB/TrEMBL),   A0A8C0TCL1 (UniProtKB/TrEMBL),   A0A8I3MCQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000030464   ⟸   ENSCAFT00000035228
RefSeq Acc Id: ENSCAFP00000022222   ⟸   ENSCAFT00000023937
RefSeq Acc Id: ENSCAFP00845001341   ⟸   ENSCAFT00845001697
Protein Domains
Peptidase metallopeptidase

Promoters
RGD ID:13683187
Promoter ID:EPDNEW_C1257
Type:single initiation site
Name:MMP7_1
Description:matrix metallopeptidase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1529,187,858 - 29,187,918EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015080 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014402 UniProtKB/TrEMBL
  ENSCAFG00040020899 UniProtKB/TrEMBL
  ENSCAFG00845000992 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000035228.5 UniProtKB/TrEMBL
  ENSCAFT00030026618.1 UniProtKB/TrEMBL
  ENSCAFT00040038721.1 UniProtKB/TrEMBL
  ENSCAFT00845001697 ENTREZGENE
  ENSCAFT00845001697.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
InterPro M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/TrEMBL
KEGG Report cfa:489432 UniProtKB/TrEMBL
NCBI Gene MMP7 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/TrEMBL
  PTHR10201:SF143 UniProtKB/TrEMBL
Pfam Peptidase_M10 UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/TrEMBL
SMART ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF47090 UniProtKB/TrEMBL
UniProt A0A8C0TCL1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MCQ8 ENTREZGENE, UniProtKB/TrEMBL
  F2YQ11 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43288 ENTREZGENE