Pnkd (PNKD metallo-beta-lactamase domain containing)

Gene: Pnkd (PNKD metallo-beta-lactamase domain containing) Chinchilla lanigera

Analyze

Symbol:

Pnkd

Name:

PNKD metallo-beta-lactamase domain containing

RGD ID:

8758203

Description:

INVOLVED IN negative regulation of neurotransmitter secretion (ortholog); neuromuscular process controlling posture (ortholog); regulation of dopamine metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); cerebrotendinous xanthomatosis (ortholog); dystonia (ortholog); FOUND IN membrane (ortholog); mitochondrion (ortholog); presynaptic cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

paroxysmal nonkinesigenic dyskinesia; PNKD, MBL domain containing; probable hydrolase PNKD

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	15,030,436 - 15,104,084 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	15,030,436 - 15,104,084 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alacrima, achalasia, and impaired intellectual development syndrome (ISO)

cerebrotendinous xanthomatosis (ISO)

dystonia (ISO)

genetic disease (ISO)

myofibrillar myopathy 1 (ISO)

Neurodevelopmental Disorders (ISO)

paroxysmal nonkinesigenic dyskinesia 1 (ISO)

renal cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of neurotransmitter secretion (ISO)

neuromuscular process controlling posture (ISO)

regulation of dopamine metabolic process (ISO)

regulation of synaptic transmission, dopaminergic (ISO)

Cellular Component

membrane (ISO)

mitochondrion (ISO)

presynaptic cytosol (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pnkd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	15,030,436 - 15,104,084 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	15,030,436 - 15,104,084 (-)	NCBI	ChiLan1.0	ChiLan1.0

PNKD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,270,519 - 218,346,793 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,269,651 - 218,346,793 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	219,135,242 - 219,211,516 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	218,843,359 - 218,919,760 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	212,901,694 - 212,978,127 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	210,988,212 - 211,064,476 (+)	NCBI		HuRef
CHM1_1	2	219,141,604 - 219,218,160 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	218,756,220 - 218,832,888 (+)	NCBI		T2T-CHM13v2.0

Pnkd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	74,323,757 - 74,392,851 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	74,324,089 - 74,392,853 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	74,284,599 - 74,353,692 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	74,284,930 - 74,353,694 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	74,331,608 - 74,400,266 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	74,218,241 - 74,286,899 (+)	NCBI		MGSCv36	mm8
Celera	1	74,846,387 - 74,914,676 (+)	NCBI		Celera
Cytogenetic Map	1	C3	NCBI
cM Map	1	38.53	NCBI

Pnkd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,317,757 - 83,386,263 (+)	NCBI		GRCr8
mRatBN7.2	9	75,868,620 - 75,937,126 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	75,867,468 - 75,937,124 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	84,314,159 - 84,382,631 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	89,443,080 - 89,511,569 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	87,829,296 - 87,897,762 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	81,566,074 - 81,634,531 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,566,074 - 81,634,534 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	81,332,155 - 81,400,726 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	73,611,610 - 73,697,690 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	73,445,105 - 73,513,517 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

PNKD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	120,902,654 - 120,979,020 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	120,917,602 - 120,993,993 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	105,529,775 - 105,606,207 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	224,127,504 - 224,204,046 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	224,127,504 - 224,204,046 (+)	Ensembl	panpan1.1		panPan2

PNKD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	24,948,763 - 25,008,542 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	24,948,932 - 25,005,144 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	25,769,014 - 25,828,461 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	24,964,913 - 25,024,609 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	24,964,994 - 25,024,608 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	24,870,239 - 24,929,662 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	24,804,494 - 24,863,959 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	24,824,128 - 24,883,632 (+)	NCBI		UU_Cfam_GSD_1.0

Pnkd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	174,457,181 - 174,522,677 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936569	799,926 - 865,700 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936569	799,963 - 865,462 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PNKD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	120,387,113 - 120,410,476 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	120,345,541 - 120,411,648 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	133,367,669 - 133,370,492 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PNKD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	104,152,005 - 104,227,624 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	104,152,081 - 104,229,219 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	95,173,913 - 95,249,814 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pnkd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624823	6,674,917 - 6,761,025 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624823	6,675,702 - 6,761,133 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005395654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005395655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005395656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013519933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01044881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01044882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01044883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01044884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01044885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01171046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000017728 ⟹ ENSCLAP00000017556

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955453	15,030,436 - 15,104,084 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000017729 ⟹ ENSCLAP00000017557

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955453	15,030,436 - 15,052,409 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000017730 ⟹ ENSCLAP00000017558

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955453	15,031,911 - 15,103,878 (-)	Ensembl

RefSeq Acc Id:

XM_005395654 ⟹ XP_005395711

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955453	15,030,436 - 15,104,084 (-)	NCBI

Sequence:

show sequence

TGACTCCGCCCCTAACAAGAGGGAAACAAGCGAGCGTGCGCGCCTCCAGGGTCTCCTGGGAAGG
GTAGTTCTCCCGGGCCCGATCTCTTAGGCTTCTGGGAGATGTAGTTTCTAATCTGTAGGCGGGA
CGGAAGGAGCGGGGGAGGCCCCTTACGCAAACTACAATTCCCGGCGGGGAGCGCGCTGAAGAGG
GGCGGGATCTGAACATGGCGGCGGTGGTAGCTGCTACGGCGCTGAAGGGCCGGGGGGCGAGAAA
TGCCCGTGTCCTCCGGGGGATCCTCTCAGGAGCCACAGCTAACAAGGCTTCTCAGAACAGGACC
AGAGCACTGCAGAGCCACAGCTCTCCAGAGAGCAAGGAGGAGCCTGAGCCCCTCTCCCCTGAGC
TGGAGTACATCCCTAGAAAGAGGGGGCGGAACCCCATGAAAGCTGTGGGACTAGCCTGGTACAG
CCTGTACACCCGCACCTGGCTCGGGTACCTCTTCTACCGGCAGCAGCTGCGCAGGGCTCGGAAT
CGCTACCCCAAAGGCCACTCCAAAACCCAGCCCCGCCTCTTCAACGGAGTGAAGGTGCTTCCCA
TCCCCGTCCTCTCGGACAACTACAGCTACCTCATCATCGACACCCAGGCCCGGCTGGCTGTGGT
TGTGGATCCTTCAGACCCTCGGGCTGTGCAGGCTTCCATCGAGAAGGAGGGAGTCACCTTGGTT
GCCATTCTCTGCACCCACAAGCACTGGGACCACAGTGGAGGGAATCGTGACCTCAGCCGGCGGC
ACCGCGACTGTCGGGTATACGGGAGCCCTCAGGATGGCATCCCCTACCTCACCCACCCCCTGTG
TCACCAAGATGTGGTTAGTGTGGGACGACTCCAGATCCGGGCCCTGGCCACCCCAGGCCACACG
CAAGGCCATCTGGTCTACCTGTTGGATGGGGAGCCCTACAGGGGTCCCTCTTGCCTCTTCTCAG
GGGACCTGCTCTTCCTCTCTGGCTGTGGACGGACCTTTGAGGGCACTGCAGAGACCATGCTGAG
CTCACTGGACACTGTGCTGGGGCTGGGGGATGACACCCTGCTGTGGCCTGGTCATGAGTATGCA
GAGGAGAACCTGGGCTTCGCGGGTGTGGTGGAACCCGAGAACCTGGCCCGGGAGAAGAAGATGC
AGTGGGTACAGAGGCAGCGGATGGAGCGCAAGAGCACGTGCCCATCCACCCTGGGAGAGGAGCG
CACCTACAACCCATTCCTGCGGACCCACTGCCTGGCGCTGCAGGAGGCTCTGGGGCCAGGCCCA
GGCCCCACCGGGGATGATGGCTGCTCCCGGGCCCAGCTCTTGGAAGAGCTCCGCCGGCTCAAGG
ACATGCACAAGAGCAAGTGAAGCCCCCACCCCAGCCCAGCCCAGCCCACCCCCACGGTGGGGAG
GCCACCCACCACCCACACGTCACCATCCTCATCACCACCTCCTCCATCGGTGCCCACTTGGCAT
CATGCACCCACCCTGGTCGGGGGGAAGGGTGGGACCAGGCAGTGAGACCAAGAGGAAGGGATCA
AAGGCTTGAAGACCCCCAGAGTGAGGCTGCGTCATCAAAGGTAAAAGGAAAAGATGGGCACCTG
GACCTCTCCAGACCCTGCTAACTTTGAGGGTCCCCTCCTCCCTTCTCCGACTTCTGGGACAGGC
ACGAACATGGAGGCTGCCGTGCTGCCCTCCCAGGAGGCCTCACTCTCACTGTAACCCTGGCACC
CAGGGAAGCAGGTGCCGTGCCAGGTTGAGTCCATTTTCCACCTTCCCCATTCACAGTTGGGGCC
TCCAGCGTGGTGCCTTGGGAAAGCAGTCACCGGCAGGGGCAGCCAGACGGGTGACCAGGACCCT
GCCCATGGCACTTTCAAAGGCACCTGCTCACCCTACACAGCTGGCCTGAGCCACCCCCACCCCC
CGCCCTCTGCCCCTGCCCTGGGCCACAAGGGCCTCCTTCCCGGGGGAGAGAGGGCCACGGCTGG
CTCGGCCGATGCACTTTCTTCATTTTGGCCCTTGTTCTTAGGAATTTCTGCCTGCCTTCTATCT
TTCTTAATTCCCCTTGTTTTATCTTCAACCTCTTTCCTCTTTGAGTTAGCGATTTATTCTTTTA
GCCCTGACATTCACCTGGCCTTTGCAGTTTGCCAGGAACACTCATTCCTGTGTGATTTTCCTTG
GCATCATTGGCCCCATCCTGGCTGGAAGGAGGAGGCTCTGTGCAGCGGGCCGGACCCTTCCGCT
CTGCTCACCCGCGTCCAGCTCTGCTTCTCTGGTCTTGGGTCCAGGCCCCTTTGGGGCCGCAGTG
AAGAACCCTCGGTCCTCAGGCAGGCGCCCATGGGTCAGCCAGAGCCTCTCTTCCTGGTCTAAGC
CTTCCGAGATGCGCTGTCCTCAGTTTCCCCTGCCCATCTGGCCTCTCCAGCCCCGCTCCTGGAG
CCCATTCTAGCAATACCACCAGACTAGTTAGCCTCCCGCCCCCAAGACATGCAGACTCTCGCCT
CGGTGCCTTTGCTCCCGCTGCTCCTCAGGCCGGAATGCCTTCCCCGCTCCTCCGCCTGGTCTGC
CTGGCAAACGCCCATCCATCTCTCCCAGGCCCCTCCCTAGGAAGGCGCCCCCGCCTCTCCCTTC
CAGGCTACCTCTGCACTTTGTAAATGCTTCTCTCTCATGGCACTTATCACATATATTTTACTTG
TTTACATGTTTGTCTCCCCTTCTAGACTGTGAATCTTTAAGGGCATGGACTGTATCTTACGCAT
CTCTCTGTATTTCTGCGCCTAGCACGGTGCCTGGCACATAGTAGGCGCTCAATAAATGTTGAAT
GAATGAATGAATGAATGATTTAA

hide sequence

RefSeq Acc Id:

XM_005395655 ⟹ XP_005395712

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955453	15,030,436 - 15,052,409 (-)	NCBI

Sequence:

show sequence

GCCCCCACCCCGCGGGTTCTGCACGTGGGGTCGGGACCGGCCGTCGCCTAGCAACGCCCGCCCC
GCCCCCGCCAGTCAACGGCTCCCGCCCCCAGCATGGCCTGGCAGGGCTGGCCCGCGCCCGGGCT
GTGGGTCTCCGGCTGCGGTCTGCTGCTCCTCGCCTTCATCCTGCTCCTGACCCCCCGCGGCTGC
CGAGCGCGGCTGGGCCTCCGCGGTCTGCTCATGACGCGCAGCCGGCGGCTGCTCTTCCGAATCG
GGTACAGCCTGTACACCCGCACCTGGCTCGGGTACCTCTTCTACCGGCAGCAGCTGCGCAGGGC
TCGGAATCGCTACCCCAAAGGCCACTCCAAAACCCAGCCCCGCCTCTTCAACGGAGTGAAGGTG
CTTCCCATCCCCGTCCTCTCGGACAACTACAGCTACCTCATCATCGACACCCAGGCCCGGCTGG
CTGTGGTTGTGGATCCTTCAGACCCTCGGGCTGTGCAGGCTTCCATCGAGAAGGAGGGAGTCAC
CTTGGTTGCCATTCTCTGCACCCACAAGCACTGGGACCACAGTGGAGGGAATCGTGACCTCAGC
CGGCGGCACCGCGACTGTCGGGTATACGGGAGCCCTCAGGATGGCATCCCCTACCTCACCCACC
CCCTGTGTCACCAAGATGTGGTTAGTGTGGGACGACTCCAGATCCGGGCCCTGGCCACCCCAGG
CCACACGCAAGGCCATCTGGTCTACCTGTTGGATGGGGAGCCCTACAGGGGTCCCTCTTGCCTC
TTCTCAGGGGACCTGCTCTTCCTCTCTGGCTGTGGACGGACCTTTGAGGGCACTGCAGAGACCA
TGCTGAGCTCACTGGACACTGTGCTGGGGCTGGGGGATGACACCCTGCTGTGGCCTGGTCATGA
GTATGCAGAGGAGAACCTGGGCTTCGCGGGTGTGGTGGAACCCGAGAACCTGGCCCGGGAGAAG
AAGATGCAGTGGGTACAGAGGCAGCGGATGGAGCGCAAGAGCACGTGCCCATCCACCCTGGGAG
AGGAGCGCACCTACAACCCATTCCTGCGGACCCACTGCCTGGCGCTGCAGGAGGCTCTGGGGCC
AGGCCCAGGCCCCACCGGGGATGATGGCTGCTCCCGGGCCCAGCTCTTGGAAGAGCTCCGCCGG
CTCAAGGACATGCACAAGAGCAAGTGAAGCCCCCACCCCAGCCCAGCCCAGCCCACCCCCACGG
TGGGGAGGCCACCCACCACCCACACGTCACCATCCTCATCACCACCTCCTCCATCGGTGCCCAC
TTGGCATCATGCACCCACCCTGGTCGGGGGGAAGGGTGGGACCAGGCAGTGAGACCAAGAGGAA
GGGATCAAAGGCTTGAAGACCCCCAGAGTGAGGCTGCGTCATCAAAGGTAAAAGGAAAAGATGG
GCACCTGGACCTCTCCAGACCCTGCTAACTTTGAGGGTCCCCTCCTCCCTTCTCCGACTTCTGG
GACAGGCACGAACATGGAGGCTGCCGTGCTGCCCTCCCAGGAGGCCTCACTCTCACTGTAACCC
TGGCACCCAGGGAAGCAGGTGCCGTGCCAGGTTGAGTCCATTTTCCACCTTCCCCATTCACAGT
TGGGGCCTCCAGCGTGGTGCCTTGGGAAAGCAGTCACCGGCAGGGGCAGCCAGACGGGTGACCA
GGACCCTGCCCATGGCACTTTCAAAGGCACCTGCTCACCCTACACAGCTGGCCTGAGCCACCCC
CACCCCCCGCCCTCTGCCCCTGCCCTGGGCCACAAGGGCCTCCTTCCCGGGGGAGAGAGGGCCA
CGGCTGGCTCGGCCGATGCACTTTCTTCATTTTGGCCCTTGTTCTTAGGAATTTCTGCCTGCCT
TCTATCTTTCTTAATTCCCCTTGTTTTATCTTCAACCTCTTTCCTCTTTGAGTTAGCGATTTAT
TCTTTTAGCCCTGACATTCACCTGGCCTTTGCAGTTTGCCAGGAACACTCATTCCTGTGTGATT
TTCCTTGGCATCATTGGCCCCATCCTGGCTGGAAGGAGGAGGCTCTGTGCAGCGGGCCGGACCC
TTCCGCTCTGCTCACCCGCGTCCAGCTCTGCTTCTCTGGTCTTGGGTCCAGGCCCCTTTGGGGC
CGCAGTGAAGAACCCTCGGTCCTCAGGCAGGCGCCCATGGGTCAGCCAGAGCCTCTCTTCCTGG
TCTAAGCCTTCCGAGATGCGCTGTCCTCAGTTTCCCCTGCCCATCTGGCCTCTCCAGCCCCGCT
CCTGGAGCCCATTCTAGCAATACCACCAGACTAGTTAGCCTCCCGCCCCCAAGACATGCAGACT
CTCGCCTCGGTGCCTTTGCTCCCGCTGCTCCTCAGGCCGGAATGCCTTCCCCGCTCCTCCGCCT
GGTCTGCCTGGCAAACGCCCATCCATCTCTCCCAGGCCCCTCCCTAGGAAGGCGCCCCCGCCTC
TCCCTTCCAGGCTACCTCTGCACTTTGTAAATGCTTCTCTCTCATGGCACTTATCACATATATT
TTACTTGTTTACATGTTTGTCTCCCCTTCTAGACTGTGAATCTTTAAGGGCATGGACTGTATCT
TACGCATCTCTCTGTATTTCTGCGCCTAGCACGGTGCCTGGCACATAGTAGGCGCTCAATAAAT
GTTGAATGAATGAATGAATGAATGATTTAA

hide sequence

RefSeq Acc Id:

XM_005395656 ⟹ XP_005395713

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955453	15,101,359 - 15,104,071 (-)	NCBI

Sequence:

show sequence

AACAAGAGGGAAACAAGCGAGCGTGCGCGCCTCCAGGGTCTCCTGGGAAGGGTAGTTCTCCCGG
GCCCGATCTCTTAGGCTTCTGGGAGATGTAGTTTCTAATCTGTAGGCGGGACGGAAGGAGCGGG
GGAGGCCCCTTACGCAAACTACAATTCCCGGCGGGGAGCGCGCTGAAGAGGGGCGGGATCTGAA
CATGGCGGCGGTGGTAGCTGCTACGGCGCTGAAGGGCCGGGGGGCGAGAAATGCCCGTGTCCTC
CGGGGGATCCTCTCAGGAGCCACAGCTAACAAGGCTTCTCAGAACAGGACCAGAGCACTGCAGA
GCCACAGCTCTCCAGAGAGCAAGGAGGAGCCTGAGCCCCTCTCCCCTGAGCTGGAGTACATCCC
TAGAAAGAGGGGGCGGAACCCCATGAAAGCTGTGGGACTAGCCTGGGCCTTCGGCTTCCCCTGT
GGTATCCTCCTGTTCATCCTCACCAAGCGGGAAGTGGACAAGGACCGTTTGAAGCAGATGAAGG
CTCGGCAGAACATGCGGGCGTCCAACACTGGCGAGTATGAGAGCCAGAGATTCAGGGCCTCCTC
CCAACATGCCCCATCCACGGAAGCTGGGTCCGGGATGCAGGCCTGAGGAGCACTGCCACCTCCC
CTAGACTGCATTTTGACTGCGAAGTCCTCGGTTTGGCCAATTCTGGCCCTTGCTTCTGAGACCA
CCAGAGGGCGCCTGAAGCCCAGACTGCTGCCAGCTCCTGCCCCTCCCACACGGAGGAGCCAGCC
ATAAGCAAATAAAGTTATTGAGCGTTTAAGTGGGAAGAAAA

hide sequence

RefSeq Acc Id:

XM_013519933 ⟹ XP_013375387

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955453	15,030,436 - 15,045,268 (-)	NCBI

Sequence:

show sequence

GCTGTGCCCTGAGAGATGTCAGGATTCCAGTACAGCCTGTACACCCGCACCTGGCTCGGGTACC
TCTTCTACCGGCAGCAGCTGCGCAGGGCTCGGAATCGCTACCCCAAAGGCCACTCCAAAACCCA
GCCCCGCCTCTTCAACGGAGTGAAGGTGCTTCCCATCCCCGTCCTCTCGGACAACTACAGCTAC
CTCATCATCGACACCCAGGCCCGGCTGGCTGTGGTTGTGGATCCTTCAGACCCTCGGGCTGTGC
AGGCTTCCATCGAGAAGGAGGGAGTCACCTTGGTTGCCATTCTCTGCACCCACAAGCACTGGGA
CCACAGTGGAGGGAATCGTGACCTCAGCCGGCGGCACCGCGACTGTCGGGTATACGGGAGCCCT
CAGGATGGCATCCCCTACCTCACCCACCCCCTGTGTCACCAAGATGTGGTTAGTGTGGGACGAC
TCCAGATCCGGGCCCTGGCCACCCCAGGCCACACGCAAGGCCATCTGGTCTACCTGTTGGATGG
GGAGCCCTACAGGGGTCCCTCTTGCCTCTTCTCAGGGGACCTGCTCTTCCTCTCTGGCTGTGGA
CGGACCTTTGAGGGCACTGCAGAGACCATGCTGAGCTCACTGGACACTGTGCTGGGGCTGGGGG
ATGACACCCTGCTGTGGCCTGGTCATGAGTATGCAGAGGAGAACCTGGGCTTCGCGGGTGTGGT
GGAACCCGAGAACCTGGCCCGGGAGAAGAAGATGCAGTGGGTACAGAGGCAGCGGATGGAGCGC
AAGAGCACGTGCCCATCCACCCTGGGAGAGGAGCGCACCTACAACCCATTCCTGCGGACCCACT
GCCTGGCGCTGCAGGAGGCTCTGGGGCCAGGCCCAGGCCCCACCGGGGATGATGGCTGCTCCCG
GGCCCAGCTCTTGGAAGAGCTCCGCCGGCTCAAGGACATGCACAAGAGCAAGTGAAGCCCCCAC
CCCAGCCCAGCCCAGCCCACCCCCACGGTGGGGAGGCCACCCACCACCCACACGTCACCATCCT
CATCACCACCTCCTCCATCGGTGCCCACTTGGCATCATGCACCCACCCTGGTCGGGGGGAAGGG
TGGGACCAGGCAGTGAGACCAAGAGGAAGGGATCAAAGGCTTGAAGACCCCCAGAGTGAGGCTG
CGTCATCAAAGGTAAAAGGAAAAGATGGGCACCTGGACCTCTCCAGACCCTGCTAACTTTGAGG
GTCCCCTCCTCCCTTCTCCGACTTCTGGGACAGGCACGAACATGGAGGCTGCCGTGCTGCCCTC
CCAGGAGGCCTCACTCTCACTGTAACCCTGGCACCCAGGGAAGCAGGTGCCGTGCCAGGTTGAG
TCCATTTTCCACCTTCCCCATTCACAGTTGGGGCCTCCAGCGTGGTGCCTTGGGAAAGCAGTCA
CCGGCAGGGGCAGCCAGACGGGTGACCAGGACCCTGCCCATGGCACTTTCAAAGGCACCTGCTC
ACCCTACACAGCTGGCCTGAGCCACCCCCACCCCCCGCCCTCTGCCCCTGCCCTGGGCCACAAG
GGCCTCCTTCCCGGGGGAGAGAGGGCCACGGCTGGCTCGGCCGATGCACTTTCTTCATTTTGGC
CCTTGTTCTTAGGAATTTCTGCCTGCCTTCTATCTTTCTTAATTCCCCTTGTTTTATCTTCAAC
CTCTTTCCTCTTTGAGTTAGCGATTTATTCTTTTAGCCCTGACATTCACCTGGCCTTTGCAGTT
TGCCAGGAACACTCATTCCTGTGTGATTTTCCTTGGCATCATTGGCCCCATCCTGGCTGGAAGG
AGGAGGCTCTGTGCAGCGGGCCGGACCCTTCCGCTCTGCTCACCCGCGTCCAGCTCTGCTTCTC
TGGTCTTGGGTCCAGGCCCCTTTGGGGCCGCAGTGAAGAACCCTCGGTCCTCAGGCAGGCGCCC
ATGGGTCAGCCAGAGCCTCTCTTCCTGGTCTAAGCCTTCCGAGATGCGCTGTCCTCAGTTTCCC
CTGCCCATCTGGCCTCTCCAGCCCCGCTCCTGGAGCCCATTCTAGCAATACCACCAGACTAGTT
AGCCTCCCGCCCCCAAGACATGCAGACTCTCGCCTCGGTGCCTTTGCTCCCGCTGCTCCTCAGG
CCGGAATGCCTTCCCCGCTCCTCCGCCTGGTCTGCCTGGCAAACGCCCATCCATCTCTCCCAGG
CCCCTCCCTAGGAAGGCGCCCCCGCCTCTCCCTTCCAGGCTACCTCTGCACTTTGTAAATGCTT
CTCTCTCATGGCACTTATCACATATATTTTACTTGTTTACATGTTTGTCTCCCCTTCTAGACTG
TGAATCTTTAAGGGCATGGACTGTATCTTACGCATCTCTCTGTATTTCTGCGCCTAGCACGGTG
CCTGGCACATAGTAGGCGCTCAATAAATGTTGAATGAATGAATGAATGAATGATTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005395711	(Get FASTA)	NCBI Sequence Viewer
	XP_005395712	(Get FASTA)	NCBI Sequence Viewer
	XP_005395713	(Get FASTA)	NCBI Sequence Viewer
	XP_013375387	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000017556
	ENSCLAP00000017556.1
	ENSCLAP00000017557
	ENSCLAP00000017557.1
	ENSCLAP00000017558.1

RefSeq Acc Id:	XP_005395711 ⟸ XM_005395654
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2VS68 (UniProtKB/TrEMBL), A0A8C2VLV4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAVVAATALKGRGARNARVLRGILSGATANKASQNRTRALQSHSSPESKEEPEPLSPELEYIP RKRGRNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLS DNYSYLIIDTQARLAVVVDPSDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCR VYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYRGPSCLFSGDLLF LSGCGRTFEGTAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLAREKKMQWVQR QRMERKSTCPSTLGEERTYNPFLRTHCLALQEALGPGPGPTGDDGCSRAQLLEELRRLKDMHKS K hide sequence

RefSeq Acc Id:	XP_005395712 ⟸ XM_005395655
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2VLT1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAWQGWPAPGLWVSGCGLLLLAFILLLTPRGCRARLGLRGLLMTRSRRLLFRIGYSLYTRTWLG YLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQARLAVVVDPSDPRA VQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVG RLQIRALATPGHTQGHLVYLLDGEPYRGPSCLFSGDLLFLSGCGRTFEGTAETMLSSLDTVLGL GDDTLLWPGHEYAEENLGFAGVVEPENLAREKKMQWVQRQRMERKSTCPSTLGEERTYNPFLRT HCLALQEALGPGPGPTGDDGCSRAQLLEELRRLKDMHKSK hide sequence

RefSeq Acc Id:	XP_005395713 ⟸ XM_005395656
- Peptide Label:	isoform X4
- Sequence:	show sequence MAAVVAATALKGRGARNARVLRGILSGATANKASQNRTRALQSHSSPESKEEPEPLSPELEYIP RKRGRNPMKAVGLAWAFGFPCGILLFILTKREVDKDRLKQMKARQNMRASNTGEYESQRFRASS QHAPSTEAGSGMQA hide sequence

RefSeq Acc Id:

XP_013375387 ⟸ XM_013519933

- Peptide Label:

isoform X3

- Sequence:

show sequence

MSGFQYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDT
QARLAVVVDPSDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIP
YLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYRGPSCLFSGDLLFLSGCGRTFEG
TAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLAREKKMQWVQRQRMERKSTCP
STLGEERTYNPFLRTHCLALQEALGPGPGPTGDDGCSRAQLLEELRRLKDMHKSK

hide sequence

RefSeq Acc Id:

ENSCLAP00000017557 ⟸ ENSCLAT00000017729

RefSeq Acc Id:

ENSCLAP00000017556 ⟸ ENSCLAT00000017728

RefSeq Acc Id:

ENSCLAP00000017558 ⟸ ENSCLAT00000017730

Protein Domains

Metallo-beta-lactamase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000012048	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000017728	ENTREZGENE
	ENSCLAT00000017728.1	UniProtKB/TrEMBL
	ENSCLAT00000017729	ENTREZGENE
	ENSCLAT00000017729.1	UniProtKB/TrEMBL
	ENSCLAT00000017730.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.15.10	UniProtKB/TrEMBL
InterPro	Clx_II_MBL	UniProtKB/TrEMBL
	DUF4748	UniProtKB/TrEMBL
	HAGH_C	UniProtKB/TrEMBL
	Hydroxyacylglutathione_Hdrlase	UniProtKB/TrEMBL
	Metallo-B-lactamas	UniProtKB/TrEMBL
	RibonucZ/Hydroxyglut_hydro	UniProtKB/TrEMBL
NCBI Gene	Pnkd	ENTREZGENE
PANTHER	BETA LACTAMASE DOMAIN	UniProtKB/TrEMBL
	HYDROLASE PNKD-RELATED	UniProtKB/TrEMBL
Pfam	DUF4748	UniProtKB/TrEMBL
	HAGH_C	UniProtKB/TrEMBL
	Lactamase_B	UniProtKB/TrEMBL
SMART	Lactamase_B	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56281	UniProtKB/TrEMBL
UniProt	A0A8C2VLT1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VLV4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VS68	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	Pnkd	PNKD metallo-beta-lactamase domain containing		PNKD, MBL domain containing	Symbol and/or name change	5135510	APPROVED
2018-08-07	Pnkd	PNKD, MBL domain containing		paroxysmal nonkinesigenic dyskinesia	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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