PNKD (PNKD metallo-beta-lactamase domain containing) - Rat Genome Database

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Gene: PNKD (PNKD metallo-beta-lactamase domain containing) Sus scrofa
Analyze
Symbol: PNKD
Name: PNKD metallo-beta-lactamase domain containing
RGD ID: 14229475
Description: ENCODES a protein that exhibits hydrolase activity (inferred); hydroxyacylglutathione hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of neurotransmitter secretion (ortholog); neuromuscular process controlling posture (ortholog); regulation of dopamine metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); cerebrotendinous xanthomatosis (ortholog); dystonia (ortholog); FOUND IN presynaptic cytosol (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: paroxysmal nonkinesigenic dyskinesia; PNKD, MBL domain containing; probable hydrolase PNKD
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,387,113 - 120,410,476 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,345,541 - 120,411,648 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,367,669 - 133,370,492 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PNKD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,387,113 - 120,410,476 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,345,541 - 120,411,648 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,367,669 - 133,370,492 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNKD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,270,519 - 218,346,793 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,269,651 - 218,346,793 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,135,242 - 219,211,516 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,843,359 - 218,919,760 (+)NCBINCBI36Build 36hg18NCBI36
Celera2212,901,694 - 212,978,127 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2210,988,212 - 211,064,476 (+)NCBIHuRef
CHM1_12219,141,604 - 219,218,160 (+)NCBICHM1_1
T2T-CHM13v2.02218,756,220 - 218,832,888 (+)NCBIT2T-CHM13v2.0
Pnkd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,323,757 - 74,392,851 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,324,089 - 74,392,853 (+)EnsemblGRCm39 Ensembl
GRCm38174,284,599 - 74,353,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,284,930 - 74,353,694 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,331,608 - 74,400,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,218,241 - 74,286,899 (+)NCBIMGSCv36mm8
Celera174,846,387 - 74,914,676 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.53NCBI
Pnkd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,317,757 - 83,386,263 (+)NCBIGRCr8
mRatBN7.2975,868,620 - 75,937,126 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,867,468 - 75,937,124 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,314,159 - 84,382,631 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,443,080 - 89,511,569 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,829,296 - 87,897,762 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,566,074 - 81,634,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,566,074 - 81,634,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,332,155 - 81,400,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,611,610 - 73,697,690 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera973,445,105 - 73,513,517 (+)NCBICelera
Cytogenetic Map9q33NCBI
Pnkd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545315,030,436 - 15,104,084 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545315,030,436 - 15,104,084 (-)NCBIChiLan1.0ChiLan1.0
PNKD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213120,902,654 - 120,979,020 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B120,917,602 - 120,993,993 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,529,775 - 105,606,207 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,127,504 - 224,204,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,127,504 - 224,204,046 (+)Ensemblpanpan1.1panPan2
PNKD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13724,948,763 - 25,008,542 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3724,948,932 - 25,005,144 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3725,769,014 - 25,828,461 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03724,964,913 - 25,024,609 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3724,964,994 - 25,024,608 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,870,239 - 24,929,662 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,804,494 - 24,863,959 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,824,128 - 24,883,632 (+)NCBIUU_Cfam_GSD_1.0
Pnkd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,457,181 - 174,522,677 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936569799,926 - 865,700 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936569799,963 - 865,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNKD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,152,005 - 104,227,624 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,152,081 - 104,229,219 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604095,173,913 - 95,249,814 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnkd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,674,917 - 6,761,025 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,675,702 - 6,761,133 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PNKD
1995 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 10
Low 10 4 3 3 2 13 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000031141   ⟹   ENSSSCP00000020530
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,345,551 - 120,411,637 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000052542   ⟹   ENSSSCP00000035603
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,345,577 - 120,413,353 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000056507   ⟹   ENSSSCP00000056700
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,387,113 - 120,410,476 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000058126   ⟹   ENSSSCP00000034064
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,386,919 - 120,409,908 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000087421   ⟹   ENSSSCP00000063986
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,345,577 - 120,413,353 (+)Ensembl
RefSeq Acc Id: XM_003361265   ⟹   XP_003361313
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115120,345,541 - 120,348,029 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076195   ⟹   XP_020931854
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115120,345,541 - 120,411,648 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076196   ⟹   XP_020931855
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115120,386,924 - 120,411,648 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076197   ⟹   XP_020931856
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115120,345,570 - 120,411,648 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076198   ⟹   XP_020931857
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115120,345,579 - 120,411,648 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020931854   ⟸   XM_021076195
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UGG2 (UniProtKB/TrEMBL),   A0A8D0W2R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003361313   ⟸   XM_003361265
- Peptide Label: isoform X4
- UniProtKB: A0A8D1ITD1 (UniProtKB/TrEMBL),   A0A8W4F8I9 (UniProtKB/TrEMBL),   A0A8D0W2L3 (UniProtKB/TrEMBL),   A0A8D0LSQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931856   ⟸   XM_021076197
- Peptide Label: isoform X3
- UniProtKB: A0A480PCP2 (UniProtKB/TrEMBL),   A0A8D0NYN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931857   ⟸   XM_021076198
- Peptide Label: isoform X3
- UniProtKB: A0A480PCP2 (UniProtKB/TrEMBL),   A0A8D0NYN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931855   ⟸   XM_021076196
- Peptide Label: isoform X2
- UniProtKB: A0A287BJJ7 (UniProtKB/TrEMBL),   A0A8D1XGQ2 (UniProtKB/TrEMBL),   A0A8D0NYN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000034064   ⟸   ENSSSCT00000058126
RefSeq Acc Id: ENSSSCP00000020530   ⟸   ENSSSCT00000031141
RefSeq Acc Id: ENSSSCP00000035603   ⟸   ENSSSCT00000052542
RefSeq Acc Id: ENSSSCP00000056700   ⟸   ENSSSCT00000056507
RefSeq Acc Id: ENSSSCP00000063986   ⟸   ENSSSCT00000087421
Protein Domains
Metallo-beta-lactamase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00000060885 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005030995 UniProtKB/TrEMBL
  ENSSSCG00015042975 UniProtKB/TrEMBL
  ENSSSCG00025020682 UniProtKB/TrEMBL
  ENSSSCG00030022351 UniProtKB/TrEMBL
  ENSSSCG00035046538 UniProtKB/TrEMBL
  ENSSSCG00040042677 UniProtKB/TrEMBL
  ENSSSCG00045033290 UniProtKB/TrEMBL
  ENSSSCG00050053227 UniProtKB/TrEMBL
  ENSSSCG00055019644 UniProtKB/TrEMBL
  ENSSSCG00060016039 UniProtKB/TrEMBL
  ENSSSCG00065010750 UniProtKB/TrEMBL
  ENSSSCG00070017626 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000056507 ENTREZGENE
  ENSSSCT00000056507.3 UniProtKB/TrEMBL
  ENSSSCT00000094005 ENTREZGENE
  ENSSSCT00000094005.1 UniProtKB/TrEMBL
  ENSSSCT00005049380.1 UniProtKB/TrEMBL
  ENSSSCT00005049409.1 UniProtKB/TrEMBL
  ENSSSCT00005049415.1 UniProtKB/TrEMBL
  ENSSSCT00005049453.1 UniProtKB/TrEMBL
  ENSSSCT00015057258.1 UniProtKB/TrEMBL
  ENSSSCT00015057309.1 UniProtKB/TrEMBL
  ENSSSCT00015057475.1 UniProtKB/TrEMBL
  ENSSSCT00025028100.1 UniProtKB/TrEMBL
  ENSSSCT00025028160.1 UniProtKB/TrEMBL
  ENSSSCT00025028172.1 UniProtKB/TrEMBL
  ENSSSCT00030031054.1 UniProtKB/TrEMBL
  ENSSSCT00030031065.1 UniProtKB/TrEMBL
  ENSSSCT00030031076.1 UniProtKB/TrEMBL
  ENSSSCT00035061890.1 UniProtKB/TrEMBL
  ENSSSCT00035061892.1 UniProtKB/TrEMBL
  ENSSSCT00035061895.1 UniProtKB/TrEMBL
  ENSSSCT00040057097.1 UniProtKB/TrEMBL
  ENSSSCT00040057216.1 UniProtKB/TrEMBL
  ENSSSCT00040057261.1 UniProtKB/TrEMBL
  ENSSSCT00040057335.1 UniProtKB/TrEMBL
  ENSSSCT00045056905.1 UniProtKB/TrEMBL
  ENSSSCT00045056999.1 UniProtKB/TrEMBL
  ENSSSCT00045057084.1 UniProtKB/TrEMBL
  ENSSSCT00045057169.1 UniProtKB/TrEMBL
  ENSSSCT00050072491.1 UniProtKB/TrEMBL
  ENSSSCT00050072498.1 UniProtKB/TrEMBL
  ENSSSCT00055038447.1 UniProtKB/TrEMBL
  ENSSSCT00055038562.1 UniProtKB/TrEMBL
  ENSSSCT00055038625.1 UniProtKB/TrEMBL
  ENSSSCT00055038739.1 UniProtKB/TrEMBL
  ENSSSCT00055038826.1 UniProtKB/TrEMBL
  ENSSSCT00060021364.1 UniProtKB/TrEMBL
  ENSSSCT00060021369.1 UniProtKB/TrEMBL
  ENSSSCT00060021372.1 UniProtKB/TrEMBL
  ENSSSCT00060021376.1 UniProtKB/TrEMBL
  ENSSSCT00065014314.1 UniProtKB/TrEMBL
  ENSSSCT00065014324.1 UniProtKB/TrEMBL
  ENSSSCT00065014328.1 UniProtKB/TrEMBL
  ENSSSCT00070034812.1 UniProtKB/TrEMBL
  ENSSSCT00070034820.1 UniProtKB/TrEMBL
  ENSSSCT00070034824.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.15.10 UniProtKB/TrEMBL
InterPro Clx_II_MBL UniProtKB/TrEMBL
  DUF4748 UniProtKB/TrEMBL
  HAGH_C UniProtKB/TrEMBL
  Hydroxyacylglutathione_Hdrlase UniProtKB/TrEMBL
  Metallo-B-lactamas UniProtKB/TrEMBL
  RibonucZ/Hydroxyglut_hydro UniProtKB/TrEMBL
KEGG Report ssc:102161004 UniProtKB/TrEMBL
NCBI Gene PNKD ENTREZGENE
PANTHER BETA LACTAMASE DOMAIN UniProtKB/TrEMBL
  HYDROLASE PNKD-RELATED UniProtKB/TrEMBL
Pfam DUF4748 UniProtKB/TrEMBL
  HAGH_C UniProtKB/TrEMBL
  Lactamase_B UniProtKB/TrEMBL
SMART Lactamase_B UniProtKB/TrEMBL
Superfamily-SCOP SSF56281 UniProtKB/TrEMBL
UniProt A0A287BJJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A480PCP2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UGG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1ULS3_PIG UniProtKB/TrEMBL
  A0A4X1ULT3_PIG UniProtKB/TrEMBL
  A0A8D0JVI0_PIG UniProtKB/TrEMBL
  A0A8D0JVI8_PIG UniProtKB/TrEMBL
  A0A8D0LRQ9_PIG UniProtKB/TrEMBL
  A0A8D0LSQ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NYN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0W2L3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0W2R7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ZWQ0_PIG UniProtKB/TrEMBL
  A0A8D1EJ93_PIG UniProtKB/TrEMBL
  A0A8D1ITD1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R214_PIG UniProtKB/TrEMBL
  A0A8D1R2K2_PIG UniProtKB/TrEMBL
  A0A8D1XGQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F8I9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:96493 ENTREZGENE