Tcl1a (TCL1 family AKT coactivator A)

Gene: Tcl1a (TCL1 family AKT coactivator A) Chinchilla lanigera

Analyze

Symbol:

Tcl1a

Name:

TCL1 family AKT coactivator A

RGD ID:

8722766

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase binding (ortholog); protein serine/threonine kinase activator activity (ortholog); INVOLVED IN intracellular signal transduction (ortholog); negative regulation of gene expression (ortholog); regulation of stem cell population maintenance (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); COVID-19 (ortholog); essential thrombocythemia (ortholog); FOUND IN cell cortex (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

T cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955438	16,934,650 - 16,952,926 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

COVID-19 (ISO)

essential thrombocythemia (ISO)

genetic disease (ISO)

Mycoplasma pneumoniae pneumonia (ISO)

myelofibrosis (ISO)

T-cell acute lymphoblastic leukemia (ISO)

T-Cell Lymphoma 1A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (ISO)

negative regulation of gene expression (ISO)

regulation of stem cell population maintenance (ISO)

somatic stem cell population maintenance (ISO)

Cellular Component

cell cortex (ISO)

cytosol (ISO)

endoplasmic reticulum (ISO)

nucleoplasm (ISO)

nucleus (ISO)

ooplasm (ISO)

pronucleus (ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

protein kinase binding (ISO)

protein serine/threonine kinase activator activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Tcl1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955438	16,934,650 - 16,952,926 (+)	NCBI	ChiLan1.0	ChiLan1.0

TCL1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	95,709,947 - 95,714,125 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	95,709,947 - 95,714,196 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	96,176,284 - 96,180,462 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	95,246,057 - 95,250,286 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	95,246,057 - 95,250,201	NCBI
Celera	14	76,232,053 - 76,236,282 (-)	NCBI		Celera
Cytogenetic Map	14	q32.13	NCBI
HuRef	14	76,361,876 - 76,366,105 (-)	NCBI		HuRef
CHM1_1	14	96,114,282 - 96,118,511 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	89,941,532 - 89,945,710 (-)	NCBI		T2T-CHM13v2.0

Tcl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	105,183,012 - 105,188,996 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	105,183,009 - 105,189,052 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	105,216,753 - 105,222,737 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	105,216,750 - 105,222,793 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	106,454,963 - 106,460,947 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	105,617,805 - 105,623,761 (-)	NCBI		MGSCv36	mm8
Celera	12	106,449,260 - 106,455,244 (-)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	55.28	NCBI

Tcl1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	129,889,763 - 129,895,756 (-)	NCBI		GRCr8
mRatBN7.2	6	124,125,032 - 124,131,025 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	124,125,032 - 124,131,025 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	124,254,793 - 124,260,933 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	124,550,061 - 124,556,201 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	123,904,588 - 123,910,717 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	128,888,768 - 128,894,761 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	128,888,768 - 128,894,761 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	138,085,869 - 138,091,862 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	129,370,968 - 129,376,961 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	129,376,456 - 129,380,647 (-)	NCBI
Celera	6	121,577,748 - 121,583,741 (-)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

TCL1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	96,865,201 - 96,869,911 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	96,081,707 - 96,086,417 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	76,339,614 - 76,343,546 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	95,664,120 - 95,667,375 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	95,664,120 - 95,667,375 (-)	Ensembl	panpan1.1		panPan2

TCL1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	8	64,109,547 - 64,115,503 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	64,799,042 - 64,805,003 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	8	64,473,243 - 64,479,198 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	64,535,078 - 64,541,036 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	64,858,694 - 64,864,651 (-)	NCBI		UU_Cfam_GSD_1.0

Tcl1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	9,951,362 - 9,954,489 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936604	127,841 - 131,056 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TCL1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	116,934,948 - 116,939,320 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	116,933,785 - 116,939,353 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	124,148,800 - 124,154,336 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TCL1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	73,556,188 - 73,570,376 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	73,566,270 - 73,570,348 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	60,724,929 - 60,738,858 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tcl1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624734	8,111,655 - 8,116,084 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013517147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01035425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01035426	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01309630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_013517147 ⟹ XP_013372601

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955438	16,934,650 - 16,952,926 (+)	NCBI

Sequence:

show sequence

TTGTTTTTGCACTGCCCAGGCGCCATGGCCGAGTCCTTGTTCTTCAACAGGCAGCTAAAGCACC
TAACCGAGCACCCCAGCCGCCTGTGGATATGGGACAAGGTCACGTTCATGGATGAGCAGCGGCG
CACCTGGCTGCCGATAATTCTCCAGACAGAGAATAACATGCAGGTGCTCATGCGGCAGGAAACG
GTCACCGTGGGGGACCCCCAGAGCCCCACCCAGCTCCGCTCATGCCCTCTGCCTCTGATGTGGC
AACACTACCCCTCCGACAGAGTATACCGAGCCAGCGACTCCACCTTATGGCGTGTAGTGTACCA
CATCGAGGACCTGCCCACTCACCAGGCTCTGCCTGTTCTCTCTCCCTCGCTGCTCTCCCAGCTG
CTCATCGTCCCTTCCTCCTTCCCTGGCTGGCTGGGGCAGCACAGCAGGATGAGGAGTTGGGAGA
CCGGGGTTCCTGGTCAGCCCGGGCTCAGAATTTGGTGTGGGGCCTGGCACACAGCAGAGGTTCT
GTGTCTCTGGAGCCCAGCCCCAGGCCCTCAGGAAGCTGCCAGGCTCAAGGACAGCACCACCAAA
GAGCAATGTGACCCAGCAGAACCGCCATACCAGAGACATTTGACATGTGAAGTCCTTAATGGTC
CCACTGAGGAAGATGTCCTTGGGCAACACAGCCGGGAAGGGCCAGGGCTGCTCCTCCGGGACGC
AGATGTCCAGAGGTGCCAGCAGCATCTGTTTTCACCAATCAGGCCTGAAGTCACAGGTGGTGGA
GGGTCTGAATGTCACCCTGCCTCAGGCCACAGGCTCATCCAAACAGCAGTACAGGGAACCCTAA
AGCGTGCCCCCTTGTGGCTGGTGATTCCAACATGCCACTCAGACCACCTGTGGCTGCCCATCCT
GCCTTAG

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Protein Sequences


Protein RefSeqs	XP_013372601	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013372601 ⟸ XM_013517147

- Sequence:

show sequence

MAESLFFNRQLKHLTEHPSRLWIWDKVTFMDEQRRTWLPIILQTENNMQVLMRQETVTVGDPQS
PTQLRSCPLPLMWQHYPSDRVYRASDSTLWRVVYHIEDLPTHQALPVLSPSLLSQLLIVPSSFP
GWLGQHSRMRSWETGVPGQPGLRIWCGAWHTAEVLCLWSPAPGPQEAARLKDSTTKEQCDPAEP
PYQRHLTCEVLNGPTEEDVLGQHSREGPGLLLRDADVQRCQQHLFSPIRPEVTGGGGSECHPAS
GHRLIQTAVQGTLKRAPLWLVIPTCHSDHLWLPILP

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Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Tcl1a	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-05-05	Tcl1a	TCL1 family AKT coactivator A	Tcl1a	T cell leukemia/lymphoma 1A	Symbol and/or name change	5135510	APPROVED
2017-12-19	Tcl1a	T cell leukemia/lymphoma 1A		T-cell leukemia/lymphoma 1A	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM