Ctsj (cathepsin J) - Rat Genome Database

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Gene: Ctsj (cathepsin J) Mus musculus
Analyze
No known orthologs.
Symbol: Ctsj
Name: cathepsin J
RGD ID: 736422
MGI Page MGI
Description: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Predicted to colocalize with perinuclear region of cytoplasm. Is expressed in several structures, including brain; extraembryonic component; and placenta.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CA; Cat P; cathepsin L-related protein; cathepsin P; catlrp-p; CATP; CatRLP; Ct; Ctsp; gene/Cathepsin L-related protein; MGC117662
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391361,147,993 - 61,153,739 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1361,147,993 - 61,153,773 (-)EnsemblGRCm39 Ensembl
GRCm381361,000,179 - 61,005,925 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1361,000,179 - 61,005,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371361,101,639 - 61,107,275 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361361,009,901 - 61,015,539 (-)NCBIMGSCv36mm8
Celera1362,038,357 - 62,043,986 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1332.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of a rat placental cDNA encoding a novel cathepsin L-related protein. Conliffe PR, etal., Mol Reprod Dev 1995 Feb;40(2):146-56.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P. Sol-Church K, etal., Biochim Biophys Acta 2000 Apr 25;1491(1-3):289-94.
Additional References at PubMed
PMID:10349636   PMID:10510293   PMID:10526153   PMID:10557321   PMID:10903127   PMID:11042159   PMID:11076861   PMID:11829493   PMID:12477932   PMID:14629193   PMID:15489334   PMID:15680921  
PMID:16141072   PMID:16141073   PMID:16862160   PMID:17531191   PMID:21873635   PMID:24391757   PMID:38355793  


Genomics

Variants

.
Variants in Ctsj
214 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:76
Interacting mature miRNAs:77
Transcripts:ENSMUST00000071526
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse

Markers in Region
Ctsj  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381361,002,477 - 61,003,815UniSTSGRCm38
MGSCv371361,103,838 - 61,105,176UniSTSGRCm37
Celera1362,040,556 - 62,041,894UniSTS
Cytogenetic Map13B2UniSTS
cM Map1335.5UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000071526   ⟹   ENSMUSP00000071457
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1361,148,092 - 61,153,725 (-)Ensembl
GRCm38.p6 Ensembl1361,000,278 - 61,005,911 (-)Ensembl
RefSeq Acc Id: ENSMUST00000224224   ⟹   ENSMUSP00000153389
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1361,147,993 - 61,153,773 (-)Ensembl
GRCm38.p6 Ensembl1361,000,179 - 61,005,959 (-)Ensembl
RefSeq Acc Id: ENSMUST00000224306
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1361,151,571 - 61,153,725 (-)Ensembl
GRCm38.p6 Ensembl1361,003,757 - 61,005,911 (-)Ensembl
RefSeq Acc Id: NM_001356291   ⟹   NP_001343220
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391361,147,993 - 61,153,739 (-)NCBI
GRCm381361,000,179 - 61,005,925 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012007   ⟹   NP_036137
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391361,147,993 - 61,153,739 (-)NCBI
GRCm381361,000,179 - 61,005,925 (-)NCBI
MGSCv371361,101,639 - 61,107,275 (-)RGD
Celera1362,038,357 - 62,043,986 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036137   ⟸   NM_012007
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0R4J0V8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001343220   ⟸   NM_001356291
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9R014 (UniProtKB/Swiss-Prot),   Q91XK6 (UniProtKB/Swiss-Prot),   Q564D9 (UniProtKB/Swiss-Prot),   Q9WV51 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000071457   ⟸   ENSMUST00000071526
RefSeq Acc Id: ENSMUSP00000153389   ⟸   ENSMUST00000224224
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R014-F1-model_v2 AlphaFold Q9R014 1-334 view protein structure

Promoters
RGD ID:8680586
Promoter ID:EPDNEW_M18324
Type:multiple initiation site
Name:Ctsj_1
Description:Mus musculus cathepsin J , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381361,005,925 - 61,005,985EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1349426 AgrOrtholog
Ensembl Genes ENSMUSG00000055298 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000071526 ENTREZGENE
  ENSMUST00000071526.6 UniProtKB/TrEMBL
  ENSMUST00000224224 ENTREZGENE
  ENSMUST00000224224.2 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26898 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1349426 ENTREZGENE
NCBI Gene 26898 ENTREZGENE
PANTHER CATHEPSIN J UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctsj PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0V8 ENTREZGENE, UniProtKB/TrEMBL
  CATJ_MOUSE UniProtKB/Swiss-Prot
  Q564D9 ENTREZGENE
  Q91XK6 ENTREZGENE
  Q9R014 ENTREZGENE
  Q9WV51 ENTREZGENE
UniProt Secondary Q564D9 UniProtKB/Swiss-Prot
  Q91XK6 UniProtKB/Swiss-Prot
  Q9WV51 UniProtKB/Swiss-Prot