CISH (cytokine inducible SH2 containing protein) - Rat Genome Database

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Gene: CISH (cytokine inducible SH2 containing protein) Homo sapiens
Analyze
Symbol: CISH
Name: cytokine inducible SH2 containing protein
RGD ID: 735426
HGNC Page HGNC:1984
Description: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within protein kinase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Implicated in malaria and tuberculosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BACTS2; CIS; CIS-1; cytokine-inducible inhibitor of signaling type 1B; cytokine-inducible SH2-containing protein; G18; SOCS; suppressor of cytokine signaling
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,606,489 - 50,611,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,606,489 - 50,611,774 (-)EnsemblGRCh38hg38GRCh38
GRCh37350,643,920 - 50,649,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,618,924 - 50,624,207 (-)NCBINCBI36Build 36hg18NCBI36
Build 34350,618,929 - 50,624,207NCBI
Celera350,616,686 - 50,622,064 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef350,699,815 - 50,705,193 (-)NCBIHuRef
CHM1_1350,596,124 - 50,601,502 (-)NCBICHM1_1
T2T-CHM13v2.0350,636,358 - 50,641,643 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
2-nitrotoluene  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrotoluene  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
andrographolide  (ISO)
aristolochic acid A  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
benzoates  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glycidol  (ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
inulin  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methylmercury(1+)  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
niclosamide  (EXP)
nitrofen  (ISO)
O-methyleugenol  (ISO)
orphenadrine  (ISO)
oxazepam  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
stattic  (EXP)
sulpiride  (ISO)
sunitinib  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7796808   PMID:9465889   PMID:9774439   PMID:10514520   PMID:10517496   PMID:10585430   PMID:10902923   PMID:10969179   PMID:11032736   PMID:11713228   PMID:12076535   PMID:12077274  
PMID:12477932   PMID:12586763   PMID:12618484   PMID:12648219   PMID:14630083   PMID:14707129   PMID:15231748   PMID:15470047   PMID:15489334   PMID:15644415   PMID:16273093   PMID:16344560  
PMID:16684815   PMID:16961462   PMID:17666591   PMID:18420585   PMID:18508766   PMID:18647318   PMID:18820827   PMID:19592657   PMID:19595407   PMID:19622774   PMID:19807022   PMID:19913121  
PMID:20484391   PMID:20628086   PMID:21234523   PMID:21383382   PMID:21873635   PMID:21988832   PMID:22033525   PMID:22213096   PMID:22817871   PMID:23426819   PMID:23867815   PMID:23898208  
PMID:23949851   PMID:24131863   PMID:24632804   PMID:24658140   PMID:24791876   PMID:24964072   PMID:25104439   PMID:25286386   PMID:25402006   PMID:25448846   PMID:25460819   PMID:25505247  
PMID:26186194   PMID:27266592   PMID:27423467   PMID:27596538   PMID:28038963   PMID:28188673   PMID:28514442   PMID:29325454   PMID:29593227   PMID:29920655   PMID:30197185   PMID:31253590  
PMID:31980649   PMID:32097462   PMID:32814053   PMID:32961483   PMID:33961781   PMID:34072601   PMID:34989544   PMID:37118554   PMID:37563692  


Genomics

Comparative Map Data
CISH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,606,489 - 50,611,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,606,489 - 50,611,774 (-)EnsemblGRCh38hg38GRCh38
GRCh37350,643,920 - 50,649,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,618,924 - 50,624,207 (-)NCBINCBI36Build 36hg18NCBI36
Build 34350,618,929 - 50,624,207NCBI
Celera350,616,686 - 50,622,064 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef350,699,815 - 50,705,193 (-)NCBIHuRef
CHM1_1350,596,124 - 50,601,502 (-)NCBICHM1_1
T2T-CHM13v2.0350,636,358 - 50,641,643 (-)NCBIT2T-CHM13v2.0
Cish
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,173,858 - 107,179,983 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,173,225 - 107,179,983 (+)EnsemblGRCm39 Ensembl
GRCm389107,296,659 - 107,302,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,296,026 - 107,302,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,199,020 - 107,204,292 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,154,790 - 107,160,062 (+)NCBIMGSCv36mm8
Celera9106,902,900 - 106,908,144 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.99NCBI
Cish
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,850,969 - 116,855,917 (+)NCBIGRCr8
mRatBN7.28107,972,306 - 107,977,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,972,306 - 107,977,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,598,881 - 113,603,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,798,056 - 111,803,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,640,844 - 109,645,801 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,054,547 - 116,059,494 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,054,465 - 116,060,723 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,411,027 - 115,415,974 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,541,034 - 112,545,982 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,560,606 - 112,564,500 (+)NCBI
Celera8107,282,095 - 107,287,043 (+)NCBICelera
Cytogenetic Map8q32NCBI
Cish
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,378,088 - 2,386,000 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,380,380 - 2,386,000 (-)NCBIChiLan1.0ChiLan1.0
CISH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,586,428 - 50,591,908 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,591,174 - 50,596,668 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,531,870 - 50,537,319 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,769,194 - 51,774,548 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,769,194 - 51,774,548 (-)Ensemblpanpan1.1panPan2
CISH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12038,762,239 - 38,767,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2038,762,378 - 38,766,620 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,681,549 - 38,686,929 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,116,466 - 39,121,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,116,453 - 39,121,845 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,484,384 - 38,489,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,887,993 - 38,893,364 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,167,907 - 39,173,288 (+)NCBIUU_Cfam_GSD_1.0
Cish
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,358,104 - 65,364,149 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365292,118,325 - 2,124,684 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365292,116,786 - 2,124,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CISH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,085,286 - 33,090,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11333,086,280 - 33,090,540 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,354,834 - 36,358,941 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CISH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,993,212 - 11,998,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,993,242 - 11,995,375 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041154,987,569 - 154,992,718 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cish
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,435,847 - 4,440,143 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,434,817 - 4,440,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CISH
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001243926.2(MAPKAPK3):c.-436A>T single nucleotide variant Bacteremia, susceptibility to, 2 [RCV000023195]|Malaria, susceptibility to [RCV000007508]|Tuberculosis, susceptibility to [RCV000007507] Chr3:50612068 [GRCh38]
Chr3:50649499 [GRCh37]
Chr3:3p21.2		 risk factor|affects
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3		 pathogenic
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p21.31-21.2(chr3:50435928-50732729)x3 copy number gain not provided [RCV000682257] Chr3:50435928..50732729 [GRCh37]
Chr3:3p21.31-21.2		 uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1		 pathogenic
NM_145071.4(CISH):c.519C>T (p.Ser173=) single nucleotide variant not provided [RCV000882205] Chr3:50607865 [GRCh38]
Chr3:50645296 [GRCh37]
Chr3:3p21.2		 benign|likely benign
NM_145071.4(CISH):c.233G>A (p.Arg78Gln) single nucleotide variant CISH-related condition [RCV003922884]|not provided [RCV000896832] Chr3:50608381 [GRCh38]
Chr3:50645812 [GRCh37]
Chr3:3p21.2		 likely benign
NM_145071.4(CISH):c.669G>A (p.Leu223=) single nucleotide variant not provided [RCV000888935] Chr3:50607715 [GRCh38]
Chr3:50645146 [GRCh37]
Chr3:3p21.2		 benign
GRCh37/hg19 3p21.31-21.2(chr3:48807193-51363558)x1 copy number loss not provided [RCV001259686] Chr3:48807193..51363558 [GRCh37]
Chr3:3p21.31-21.2		 pathogenic
NM_145071.4(CISH):c.698G>A (p.Arg233His) single nucleotide variant not provided [RCV001354173] Chr3:50607686 [GRCh38]
Chr3:50645117 [GRCh37]
Chr3:3p21.2		 uncertain significance
NC_000003.11:g.(?_49547968)_(50685477_?)del deletion Early infantile epileptic encephalopathy with suppression bursts [RCV001970206] Chr3:49547968..50685477 [GRCh37]
Chr3:3p21.31-21.2		 pathogenic
NC_000003.11:g.(?_50431520)_(50685477_?)dup duplication not provided [RCV001959795] Chr3:50431520..50685477 [GRCh37]
Chr3:3p21.31-21.2		 uncertain significance
NC_000003.11:g.(?_50540629)_(50655235_?)dup duplication not provided [RCV002016824] Chr3:50540629..50655235 [GRCh37]
Chr3:3p21.31-21.2		 uncertain significance
NM_145071.4(CISH):c.733C>G (p.Arg245Gly) single nucleotide variant Inborn genetic diseases [RCV002779809] Chr3:50607651 [GRCh38]
Chr3:50645082 [GRCh37]
Chr3:3p21.2		 uncertain significance
NM_145071.4(CISH):c.46C>T (p.Arg16Trp) single nucleotide variant Inborn genetic diseases [RCV002818397] Chr3:50608568 [GRCh38]
Chr3:50645999 [GRCh37]
Chr3:3p21.2		 uncertain significance
NM_145071.4(CISH):c.662G>A (p.Arg221His) single nucleotide variant Inborn genetic diseases [RCV002872966] Chr3:50607722 [GRCh38]
Chr3:50645153 [GRCh37]
Chr3:3p21.2		 uncertain significance
NM_145071.4(CISH):c.650G>A (p.Arg217Lys) single nucleotide variant Inborn genetic diseases [RCV002666427] Chr3:50607734 [GRCh38]
Chr3:50645165 [GRCh37]
Chr3:3p21.2		 uncertain significance
NM_145071.4(CISH):c.20+1222A>G single nucleotide variant Inborn genetic diseases [RCV002956966] Chr3:50610409 [GRCh38]
Chr3:50647840 [GRCh37]
Chr3:3p21.2		 uncertain significance
NM_145071.4(CISH):c.523A>G (p.Ser175Gly) single nucleotide variant Inborn genetic diseases [RCV002748253] Chr3:50607861 [GRCh38]
Chr3:50645292 [GRCh37]
Chr3:3p21.2		 uncertain significance
NM_145071.4(CISH):c.428A>G (p.Asn143Ser) single nucleotide variant Inborn genetic diseases [RCV002989105] Chr3:50607956 [GRCh38]
Chr3:50645387 [GRCh37]
Chr3:3p21.2		 uncertain significance
NM_145071.4(CISH):c.532C>T (p.Pro178Ser) single nucleotide variant Inborn genetic diseases [RCV003370928] Chr3:50607852 [GRCh38]
Chr3:50645283 [GRCh37]
Chr3:3p21.2		 uncertain significance
NM_145071.4(CISH):c.138G>A (p.Val46=) single nucleotide variant CISH-related condition [RCV003898982] Chr3:50608476 [GRCh38]
Chr3:50645907 [GRCh37]
Chr3:3p21.2		 likely benign
NM_145071.4(CISH):c.*6C>T single nucleotide variant CISH-related condition [RCV003924147] Chr3:50607601 [GRCh38]
Chr3:50645032 [GRCh37]
Chr3:3p21.2		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1616
Count of miRNA genes:599
Interacting mature miRNAs:685
Transcripts:ENST00000348721, ENST00000443053, ENST00000491847
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH94332  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37350,644,101 - 50,644,236UniSTSGRCh37
Build 36350,619,105 - 50,619,240RGDNCBI36
Celera350,616,902 - 50,617,037RGD
Cytogenetic Map3p21.3UniSTS
HuRef350,700,031 - 50,700,166UniSTS
GeneMap99-GB4 RH Map3161.87UniSTS
CISH_308  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37350,644,057 - 50,644,824UniSTSGRCh37
Build 36350,619,061 - 50,619,828RGDNCBI36
Celera350,616,858 - 50,617,625RGD
HuRef350,699,987 - 50,700,754UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1184 1485 1282 402 991 298 2598 1044 580 299 686 1343 104 851 1663 1
Low 1245 1500 436 220 865 165 1745 1149 2397 114 752 235 68 1 353 1125 3 1
Below cutoff 7 3 6 1 61 2 12 2 735 4 20 32 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011533329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047447398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF035946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF035947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF511692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA435538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA957793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z77852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000348721   ⟹   ENSP00000294173
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,606,489 - 50,611,774 (-)Ensembl
RefSeq Acc Id: ENST00000443053   ⟹   ENSP00000409346
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,606,496 - 50,611,772 (-)Ensembl
RefSeq Acc Id: ENST00000491847
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,606,490 - 50,611,761 (-)Ensembl
RefSeq Acc Id: NM_013324   ⟹   NP_037456
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,606,489 - 50,611,774 (-)NCBI
GRCh37350,643,885 - 50,649,262 (-)ENTREZGENE
HuRef350,699,815 - 50,705,193 (-)ENTREZGENE
CHM1_1350,596,124 - 50,601,502 (-)NCBI
T2T-CHM13v2.0350,636,358 - 50,641,643 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145071   ⟹   NP_659508
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,606,489 - 50,611,774 (-)NCBI
GRCh37350,643,885 - 50,649,262 (-)NCBI
Build 36350,618,924 - 50,624,207 (-)NCBI Archive
HuRef350,699,815 - 50,705,193 (-)ENTREZGENE
CHM1_1350,596,124 - 50,601,502 (-)NCBI
T2T-CHM13v2.0350,636,358 - 50,641,643 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047447398   ⟹   XP_047303354
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,606,489 - 50,610,536 (-)NCBI
RefSeq Acc Id: XM_054345136   ⟹   XP_054201111
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0350,636,358 - 50,640,405 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_659508   ⟸   NM_145071
- Peptide Label: isoform 2
- UniProtKB: Q9NS38 (UniProtKB/Swiss-Prot),   G5E9R1 (UniProtKB/Swiss-Prot),   B2R9N1 (UniProtKB/Swiss-Prot),   Q9Y5R1 (UniProtKB/Swiss-Prot),   Q9NSE2 (UniProtKB/Swiss-Prot),   Q71V34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_037456   ⟸   NM_013324
- Peptide Label: isoform 1
- UniProtKB: Q71V34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000294173   ⟸   ENST00000348721
RefSeq Acc Id: ENSP00000409346   ⟸   ENST00000443053
RefSeq Acc Id: XP_047303354   ⟸   XM_047447398
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054201111   ⟸   XM_054345136
- Peptide Label: isoform X1
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NSE2-F1-model_v2 AlphaFold Q9NSE2 1-258 view protein structure

Promoters
RGD ID:6864548
Promoter ID:EPDNEW_H5439
Type:initiation region
Name:CISH_1
Description:cytokine inducible SH2 containing protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5441  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,611,774 - 50,611,834EPDNEW
RGD ID:6864552
Promoter ID:EPDNEW_H5441
Type:multiple initiation site
Name:CISH_2
Description:cytokine inducible SH2 containing protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5439  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,612,315 - 50,612,375EPDNEW
RGD ID:6800768
Promoter ID:HG_KWN:45153
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_013324,   NM_145071,   OTTHUMT00000346247
Position:
Human AssemblyChrPosition (strand)Source
Build 36350,621,071 - 50,624,227 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1984 AgrOrtholog
COSMIC CISH COSMIC
Ensembl Genes ENSG00000114737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000348721 ENTREZGENE
  ENST00000348721.4 UniProtKB/Swiss-Prot
  ENST00000443053 ENTREZGENE
  ENST00000443053.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000114737 GTEx
HGNC ID HGNC:1984 ENTREZGENE
Human Proteome Map CISH Human Proteome Map
InterPro CIS_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1154 UniProtKB/Swiss-Prot
NCBI Gene 1154 ENTREZGENE
OMIM 602441 OMIM
PANTHER CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10155:SF9 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26521 PharmGKB
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SH2 domain UniProtKB/TrEMBL
  SOCS box-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt B2R9N1 ENTREZGENE
  CISH_HUMAN UniProtKB/Swiss-Prot
  G5E9R1 ENTREZGENE
  Q71V34 ENTREZGENE, UniProtKB/TrEMBL
  Q9NS38 ENTREZGENE
  Q9NSE2 ENTREZGENE
  Q9Y5R1 ENTREZGENE
UniProt Secondary B2R9N1 UniProtKB/Swiss-Prot
  G5E9R1 UniProtKB/Swiss-Prot
  Q9NS38 UniProtKB/Swiss-Prot
  Q9Y5R1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 CISH  cytokine inducible SH2 containing protein  CISH  cytokine inducible SH2-containing protein  Symbol and/or name change 5135510 APPROVED