Mup5 (major urinary protein 5) - Rat Genome Database

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Gene: Mup5 (major urinary protein 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mup5 (Ensembl: LOC298116)
Name: major urinary protein 5 (Ensembl:alpha-2u-globulin (L type))
RGD ID: 735107
Description: Predicted to enable pheromone binding activity and small molecule binding activity. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-2u globulin PGCL5; alpha-2u globulin PGCL6; LOC298107; PGCL6
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8579,996,023 - 79,999,893 (-)NCBIGRCr8
mRatBN7.2575,201,324 - 75,204,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl575,142,157 - 75,564,845 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx577,101,006 - 77,104,392 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0578,922,668 - 78,926,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0578,894,822 - 78,898,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0577,744,217 - 77,903,161 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl577,405,142 - 77,903,113 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0581,870,535 - 81,875,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4578,468,165 - 78,471,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1578,473,277 - 78,476,680 (-)NCBI
Celera573,992,412 - 73,995,819 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Molecular evidence of complex tissue- and sex-specific mRNA expression of the rat alpha(2u)-globulin multigene family. Saito K, etal., Biochem Biophys Res Commun 2000 Jun 7;272(2):337-44.
Additional References at PubMed
PMID:21619679  


Genomics

Variants

.
Variants in Mup5
141 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:111
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000012293, ENSRNOT00000046857, ENSRNOT00000073954
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat

Markers in Region
RH130736  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2575,142,184 - 75,142,391 (+)MAPPERmRatBN7.2
mRatBN7.2575,394,151 - 75,394,358 (+)MAPPERmRatBN7.2
mRatBN7.2574,842,350 - 74,842,557 (+)MAPPERmRatBN7.2
Rnor_6.0577,549,951 - 77,550,157NCBIRnor6.0
Rnor_6.0577,744,252 - 77,744,458NCBIRnor6.0
Rnor_5.0581,870,493 - 81,870,699UniSTSRnor5.0
Rnor_5.0581,680,425 - 81,680,631UniSTSRnor5.0
RH 3.4 Map5556.7UniSTS
Cytogenetic Map5q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 3 3
Medium 6 6 6
Low 2 2 1 1 1 1 1 1 3 1 1
Below cutoff 2 10 10 2 9 2 3 5 14 4 11 8 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012293   ⟹   ENSRNOP00000012293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,221,343 - 75,316,567 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000059320   ⟹   ENSRNOP00000056082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,201,491 - 75,316,606 (-)Ensembl
Rnor_6.0 Ensembl577,405,142 - 77,903,101 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000073954   ⟹   ENSRNOP00000064857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl577,900,780 - 77,903,062 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000074349   ⟹   ENSRNOP00000067018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,171,958 - 75,204,822 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076074   ⟹   ENSRNOP00000068018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl577,899,666 - 77,903,113 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076466   ⟹   ENSRNOP00000068285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,201,416 - 75,283,184 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076791   ⟹   ENSRNOP00000067914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,314,410 - 75,316,625 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089382   ⟹   ENSRNOP00000068776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl577,549,993 - 77,903,101 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094674   ⟹   ENSRNOP00000084655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,221,343 - 75,564,845 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100434   ⟹   ENSRNOP00000080129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,142,157 - 75,224,768 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106951   ⟹   ENSRNOP00000088900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,495,447 - 75,564,827 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116257   ⟹   ENSRNOP00000093267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,201,401 - 75,204,929 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120034   ⟹   ENSRNOP00000092008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,167,219 - 75,224,768 (-)Ensembl
RefSeq Acc Id: NM_203325   ⟹   NP_976070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8579,996,293 - 79,999,695 (-)NCBI
mRatBN7.2575,201,401 - 75,204,803 (-)NCBI
Rnor_5.0581,870,535 - 81,875,854 (-)NCBI
RGSC_v3.4578,468,165 - 78,471,567 (-)RGD
Celera573,992,412 - 73,995,819 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109478   ⟹   XP_038965406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8579,996,023 - 79,999,893 (-)NCBI
mRatBN7.2575,201,324 - 75,204,903 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_976070   ⟸   NM_203325
- Peptide Label: precursor
- UniProtKB: A6KDY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068776   ⟸   ENSRNOT00000089382
RefSeq Acc Id: ENSRNOP00000064857   ⟸   ENSRNOT00000073954
RefSeq Acc Id: ENSRNOP00000056082   ⟸   ENSRNOT00000059320
RefSeq Acc Id: ENSRNOP00000068018   ⟸   ENSRNOT00000076074
RefSeq Acc Id: XP_038965406   ⟸   XM_039109478
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AJN1 (UniProtKB/TrEMBL),   Q9JJI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088900   ⟸   ENSRNOT00000106951
RefSeq Acc Id: ENSRNOP00000067018   ⟸   ENSRNOT00000074349
RefSeq Acc Id: ENSRNOP00000068285   ⟸   ENSRNOT00000076466
RefSeq Acc Id: ENSRNOP00000093267   ⟸   ENSRNOT00000116257
RefSeq Acc Id: ENSRNOP00000084655   ⟸   ENSRNOT00000094674
RefSeq Acc Id: ENSRNOP00000012293   ⟸   ENSRNOT00000012293
RefSeq Acc Id: ENSRNOP00000092008   ⟸   ENSRNOT00000120034
RefSeq Acc Id: ENSRNOP00000080129   ⟸   ENSRNOT00000100434
RefSeq Acc Id: ENSRNOP00000067914   ⟸   ENSRNOT00000076791
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQM1-F1-model_v2 AlphaFold F1LQM1 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735107 AgrOrtholog
BioCyc Gene G2FUF-41118 BioCyc
Ensembl Genes ENSRNOG00000050595 Ensembl
  ENSRNOG00000067602 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012293.5 UniProtKB/TrEMBL
  ENSRNOT00000074349.3 UniProtKB/TrEMBL
  ENSRNOT00000076466.2 UniProtKB/TrEMBL
  ENSRNOT00000076791.3 UniProtKB/TrEMBL
  ENSRNOT00000094674.1 UniProtKB/TrEMBL
  ENSRNOT00000106951.1 UniProtKB/TrEMBL
  ENSRNOT00000116257 ENTREZGENE
  ENSRNOT00000116257.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/TrEMBL
  Maj_urinary UniProtKB/TrEMBL
KEGG Report rno:298107 UniProtKB/TrEMBL
NCBI Gene 298107 ENTREZGENE
PANTHER MAJOR URINARY PROTEIN 1-RELATED UniProtKB/TrEMBL
  PTHR11430 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PhenoGen Mup5 PhenoGen
PRINTS LIPOCALIN UniProtKB/TrEMBL
  MAJORURINARY UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050595 RatGTEx
  ENSRNOG00000067602 RatGTEx
Superfamily-SCOP Calycin UniProtKB/TrEMBL
UniProt A0A096MIX6_RAT UniProtKB/TrEMBL
  A0A096MJW3_RAT UniProtKB/TrEMBL
  A0A8I5ZYK0_RAT UniProtKB/TrEMBL
  A0A8I6A7F8_RAT UniProtKB/TrEMBL
  A0A8I6AJN1 ENTREZGENE, UniProtKB/TrEMBL
  A6KDY3 ENTREZGENE, UniProtKB/TrEMBL
  F7ET54_RAT UniProtKB/TrEMBL
  M0RBS2_RAT UniProtKB/TrEMBL
  Q9JJI1 ENTREZGENE, UniProtKB/TrEMBL
  Q9JJI2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mup5  major urinary protein 5  LOC298107  alpha-2u globulin  Symbol and Name updated 1299863 APPROVED