Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of CYP2D9 mRNA | CTD | PMID:28189721 and PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of CYP2D9 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of CYP2D9 mRNA | CTD | PMID:12072388 | 1H-pyrazole | decreases expression | EXP | | 6480464 | pyrazole results in decreased expression of CYP2D9 mRNA | CTD | PMID:17945193 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2D9 mRNA] and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP2D9 gene] | CTD | PMID:22978700 and PMID:28213091 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CYP2D9 mRNA | CTD | PMID:26377647 and PMID:28922406 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CYP2D9 mRNA | CTD | PMID:19770486 more ... | 3-methylcholanthrene | multiple interactions | EXP | | 6480464 | Methylcholanthrene results in decreased expression of and results in decreased activity of CYP2D9 protein and POR gene mutant form inhibits the reaction [Methylcholanthrene affects the expression of CYP2D9 protein] | CTD | PMID:22978700 and PMID:23169610 | 3-methylcholanthrene | increases expression | EXP | | 6480464 | Methylcholanthrene results in increased expression of CYP2D9 mRNA | CTD | PMID:30503582 | 3-methylcholanthrene | decreases expression | EXP | | 6480464 | Methylcholanthrene results in decreased expression of CYP2D9 mRNA | CTD | PMID:22978700 and PMID:23169610 | 3-methylcholanthrene | affects expression | EXP | | 6480464 | Methylcholanthrene affects the expression of CYP2D9 protein | CTD | PMID:23169610 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of CYP2D9 mRNA | CTD | PMID:28973697 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of CYP2D9 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of CYP2D9 protein | CTD | PMID:34472326 | buta-1,3-diene | decreases expression | EXP | | 6480464 | 1 and 3-butadiene results in decreased expression of CYP2D9 mRNA | CTD | PMID:29038090 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon results in increased expression of CYP2D9 mRNA | CTD | PMID:25620056 | choline | multiple interactions | EXP | | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA and [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of CYP2D9 mRNA | CTD | PMID:33549593 | cyanocob(III)alamin | multiple interactions | EXP | | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA and [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of CYP2D9 mRNA | CTD | PMID:33549593 | cyproconazole | increases expression | EXP | | 6480464 | cyproconazole results in increased expression of CYP2D9 mRNA | CTD | PMID:22334560 | dextran sulfate | multiple interactions | EXP | | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CYP2D9 mRNA | CTD | PMID:29950665 | dextromethorphan | increases metabolic processing | EXP | | 6480464 | CYP2D9 protein results in increased metabolism of Dextromethorphan | CTD | PMID:30503582 | dextromethorphan | multiple interactions | EXP | | 6480464 | [CYP2D9 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan | CTD | PMID:30503582 | dextrorphan | multiple interactions | EXP | | 6480464 | [CYP2D9 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan | CTD | PMID:30503582 | diquat | increases expression | EXP | | 6480464 | Diquat results in increased expression of CYP2D9 mRNA | CTD | PMID:36851058 | epoxiconazole | increases expression | EXP | | 6480464 | epoxiconazole results in increased expression of CYP2D9 mRNA | CTD | PMID:22334560 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA and [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of CYP2D9 mRNA | CTD | PMID:33549593 | glycine betaine | multiple interactions | EXP | | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA and [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of CYP2D9 mRNA | CTD | PMID:33549593 | indometacin | multiple interactions | EXP | | 6480464 | TLR4 protein affects the reaction [Indomethacin results in decreased activity of CYP2D9 protein] | CTD | PMID:12927920 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA and [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of CYP2D9 mRNA | CTD | PMID:33549593 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CYP2D9 protein | CTD | PMID:21329376 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of CYP2D9 mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | affects expression | EXP | | 6480464 | perfluorooctanoic acid affects the expression of CYP2D9 mRNA | CTD | PMID:18281256 | phenobarbital | multiple interactions | EXP | | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA | CTD | PMID:33549593 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CYP2D9 mRNA | CTD | PMID:33549593 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of CYP2D9 mRNA | CTD | PMID:17950772 and PMID:20813756 | potassium dichromate | affects expression | EXP | | 6480464 | Potassium Dichromate affects the expression of CYP2D9 mRNA | CTD | PMID:23608068 | prochloraz | increases expression | EXP | | 6480464 | prochloraz results in increased expression of CYP2D9 protein | CTD | PMID:33150952 | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of CYP2D9 mRNA | CTD | PMID:22334560 | rifampicin | decreases expression | EXP | | 6480464 | Rifampin results in decreased expression of CYP2D9 mRNA | CTD | PMID:30503582 | sodium arsenite | affects expression | EXP | | 6480464 | sodium arsenite affects the expression of CYP2D9 mRNA | CTD | PMID:16507464 | sodium arsenite | multiple interactions | EXP | | 6480464 | NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP2D9 mRNA] | CTD | PMID:33933676 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of CYP2D9 mRNA and sodium arsenite results in increased expression of CYP2D9 protein | CTD | PMID:29044176 and PMID:33933676 | testosterone | increases expression | EXP | | 6480464 | Testosterone results in increased expression of CYP2D9 mRNA | CTD | PMID:20844152 and PMID:21669218 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CYP2D9 mRNA | CTD | PMID:31919559 | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of CYP2D9 mRNA | CTD | PMID:23557971 | titanium dioxide | multiple interactions | EXP | | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CYP2D9 mRNA | CTD | PMID:29950665 | trichloroethene | multiple interactions | EXP | | 6480464 | PPARA protein inhibits the reaction [Trichloroethylene results in increased expression of CYP2D9 protein] | CTD | PMID:15363585 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of CYP2D9 mRNA | CTD | PMID:15363585 | XL147 | multiple interactions | EXP | | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CYP2D9 mRNA | CTD | PMID:27935865 | zinc atom | multiple interactions | EXP | | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA and [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of CYP2D9 mRNA | CTD | PMID:33549593 | zinc(0) | multiple interactions | EXP | | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA and [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 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Gene Ontology Annotations Click to see Annotation Detail View
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