Akap4 (A kinase anchor protein 4) - Rat Genome Database

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Gene: Akap4 (A kinase anchor protein 4) Mus musculus
Analyze
Symbol: Akap4
Name: A kinase anchor protein 4 (Ensembl:A kinase (PRKA) anchor protein 4)
RGD ID: 732831
MGI Page MGI
Description: Enables protein kinase A binding activity. Involved in flagellated sperm motility. Acts upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; establishment of protein localization; and sperm flagellum assembly. Located in Z disc; perinuclear region of cytoplasm; and sperm flagellum. Orthologous to human AKAP4 (A-kinase anchoring protein 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A kinase (PRKA) anchor protein 4; A kinase anchoring protein 4; A-kinase anchor protein 4; A-kinase anchor protein 82 kDa; AKAP 82; AKAP-4; AKAP82; Fsc; Fsc1; major sperm fibrous sheath protein; mAKAP82; p82; PRKA4; protein kinase A-anchoring protein 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X6,933,754 - 6,944,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX6,933,758 - 6,944,848 (+)EnsemblGRCm39 Ensembl
GRCm38X7,067,515 - 7,078,609 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,067,519 - 7,078,609 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X6,644,645 - 6,655,735 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,224,469 - 6,235,378 (+)NCBIMGSCv36mm8
MGSCv36X3,237,368 - 3,248,069 (+)NCBIMGSCv36mm8
CeleraX4,385,111 - 4,395,986 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Miki K, etal., Dev Biol 2002 Aug 15;248(2):331-42.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
Additional References at PubMed
PMID:7711182   PMID:8088444   PMID:9021145   PMID:9344676   PMID:9822690   PMID:9852104   PMID:10319321   PMID:10349636   PMID:10857745   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11803562   PMID:12079992   PMID:12466851   PMID:12477932   PMID:12606363   PMID:15385410   PMID:16141072   PMID:16141073   PMID:16687648   PMID:16687649   PMID:17923693   PMID:20731842  
PMID:21715716   PMID:21873635   PMID:21923911   PMID:23675479   PMID:31146259   PMID:31255637   PMID:31969357   PMID:33023073   PMID:33486757   PMID:33913480   PMID:34415320   PMID:35967402  


Genomics

Comparative Map Data
Akap4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X6,933,754 - 6,944,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX6,933,758 - 6,944,848 (+)EnsemblGRCm39 Ensembl
GRCm38X7,067,515 - 7,078,609 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,067,519 - 7,078,609 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X6,644,645 - 6,655,735 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,224,469 - 6,235,378 (+)NCBIMGSCv36mm8
MGSCv36X3,237,368 - 3,248,069 (+)NCBIMGSCv36mm8
CeleraX4,385,111 - 4,395,986 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.17NCBI
AKAP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X50,190,777 - 50,201,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX50,190,777 - 50,201,007 (-)EnsemblGRCh38hg38GRCh38
GRCh37X49,955,420 - 49,965,658 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X49,842,151 - 49,852,404 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X49,658,457 - 49,668,040NCBI
CeleraX54,024,511 - 54,034,765 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX47,427,699 - 47,437,860 (-)NCBIHuRef
CHM1_1X50,035,048 - 50,045,361 (-)NCBICHM1_1
T2T-CHM13v2.0X49,508,429 - 49,518,665 (-)NCBIT2T-CHM13v2.0
Akap4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X18,107,256 - 18,117,549 (-)NCBIGRCr8
mRatBN7.2X15,435,391 - 15,445,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX15,435,410 - 15,445,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX20,251,578 - 20,261,972 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X19,821,331 - 19,831,725 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,086,288 - 16,096,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X16,296,027 - 16,306,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX16,296,735 - 16,306,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X17,081,382 - 17,091,111 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,515,009 - 27,524,606 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X27,568,477 - 27,578,075 (-)NCBI
CeleraX15,510,282 - 15,520,669 (-)NCBICelera
Cytogenetic MapXq12NCBI
Akap4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555431,357,997 - 1,367,897 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555431,358,086 - 1,367,838 (+)NCBIChiLan1.0ChiLan1.0
AKAP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X51,609,197 - 51,621,892 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X51,612,573 - 51,625,268 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X42,396,399 - 42,406,725 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X50,109,391 - 50,119,651 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX50,109,367 - 50,119,658 (-)Ensemblpanpan1.1panPan2
AKAP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,935,831 - 42,946,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,935,815 - 42,946,149 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX17,313,189 - 17,323,613 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X43,074,974 - 43,085,399 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX43,074,994 - 43,085,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X43,060,826 - 43,071,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X43,048,110 - 43,058,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X43,143,002 - 43,153,434 (-)NCBIUU_Cfam_GSD_1.0
Akap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X35,452,021 - 35,462,091 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,692,623 - 1,702,348 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367211,692,623 - 1,700,256 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,885,394 - 43,895,981 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,885,584 - 43,895,142 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,812,671 - 48,822,999 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X47,046,209 - 47,056,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX47,046,240 - 47,056,319 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666086628,681 - 638,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248931,759,045 - 1,767,918 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248931,759,148 - 1,767,831 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap4
259 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:441
Count of miRNA genes:146
Interacting mature miRNAs:150
Transcripts:ENSMUST00000057101, ENSMUST00000115750, ENSMUST00000115751
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse

Markers in Region
U10341  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,078,494 - 7,078,595UniSTSGRCm38
MGSCv37X6,655,620 - 6,655,721UniSTSGRCm37
CeleraX4,385,125 - 4,385,226UniSTS
Cytogenetic MapXA1.1UniSTS
Whitehead_YACX UniSTS
Akap4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA1.1UniSTS
cM MapX1.6UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000057101   ⟹   ENSMUSP00000050962
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX6,933,758 - 6,944,848 (+)Ensembl
GRCm38.p6 EnsemblX7,067,519 - 7,078,609 (+)Ensembl
RefSeq Acc Id: ENSMUST00000115750   ⟹   ENSMUSP00000111416
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX6,933,759 - 6,944,843 (+)Ensembl
GRCm38.p6 EnsemblX7,067,520 - 7,078,604 (+)Ensembl
RefSeq Acc Id: ENSMUST00000115751   ⟹   ENSMUSP00000111417
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX6,934,452 - 6,944,830 (+)Ensembl
GRCm38.p6 EnsemblX7,068,213 - 7,078,591 (+)Ensembl
RefSeq Acc Id: NM_001042542   ⟹   NP_001036007
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X6,934,449 - 6,944,848 (+)NCBI
GRCm38X7,068,210 - 7,078,609 (+)NCBI
MGSCv37X6,644,645 - 6,655,735 (+)RGD
CeleraX4,385,111 - 4,395,990 (-)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009651   ⟹   NP_033781
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X6,933,754 - 6,944,848 (+)NCBI
GRCm38X7,067,515 - 7,078,609 (+)NCBI
MGSCv37X6,644,645 - 6,655,735 (+)RGD
CeleraX4,385,111 - 4,395,990 (-)NCBI
cM MapX ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033781   ⟸   NM_009651
- Peptide Label: isoform a
- UniProtKB: Q60630 (UniProtKB/Swiss-Prot),   B1AXM7 (UniProtKB/Swiss-Prot),   Q8R2G7 (UniProtKB/Swiss-Prot),   Q60662 (UniProtKB/Swiss-Prot),   A1L3T6 (UniProtKB/TrEMBL),   Q9Z263 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001036007   ⟸   NM_001042542
- Peptide Label: isoform b
- UniProtKB: Q9Z263 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000111416   ⟸   ENSMUST00000115750
RefSeq Acc Id: ENSMUSP00000111417   ⟸   ENSMUST00000115751
RefSeq Acc Id: ENSMUSP00000050962   ⟸   ENSMUST00000057101
Protein Domains
A-kinase anchor 110kDa C-terminal   RII binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60662-F1-model_v2 AlphaFold Q60662 1-849 view protein structure

Promoters
RGD ID:6845444
Promoter ID:MM_KWN:59382
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_001042542
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X6,644,206 - 6,644,706 (+)MPROMDB
RGD ID:13679948
Promoter ID:EPDNEW_M24123
Type:multiple initiation site
Name:Akap4_1
Description:Mus musculus A kinase anchor protein 4 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X7,068,213 - 7,068,273EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102794 AgrOrtholog
Ensembl Genes ENSMUSG00000050089 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000057101 ENTREZGENE
  ENSMUST00000057101.13 UniProtKB/Swiss-Prot
  ENSMUST00000115750.8 UniProtKB/Swiss-Prot
  ENSMUST00000115751 ENTREZGENE
  ENSMUST00000115751.3 UniProtKB/Swiss-Prot
InterPro AKAP_110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AKAP_110_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RII_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPHK1-interactor_AKAP_110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11643 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:102794 ENTREZGENE
NCBI Gene 11643 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10226 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AKAP_110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RII_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akap4 PhenoGen
SMART AKAP_110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1L3T6 ENTREZGENE, UniProtKB/TrEMBL
  AKAP4_MOUSE UniProtKB/Swiss-Prot
  B1AXM7 ENTREZGENE
  Q60630 ENTREZGENE
  Q60662 ENTREZGENE
  Q8R2G7 ENTREZGENE
  Q9D3Z3_MOUSE UniProtKB/TrEMBL
  Q9Z263 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B1AXM7 UniProtKB/Swiss-Prot
  Q60630 UniProtKB/Swiss-Prot
  Q8R2G7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Akap4  A kinase anchor protein 4  Akap4  A kinase (PRKA) anchor protein 4  Symbol and/or name change 5135510 APPROVED