Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | P2ry6 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of P2RY6 mRNA] | CTD | PMID:31150632 | 1,1-dichloroethene | increases expression | EXP | | 6480464 | vinylidene chloride results in increased expression of P2RY6 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of P2RY6 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of P2RY6 mRNA | CTD | PMID:12655037 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of P2RY6 mRNA | CTD | PMID:19484750 | 17beta-estradiol | multiple interactions | ISO | P2RY6 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of P2RY6 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of P2RY6 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of P2RY6 mRNA | CTD | PMID:33387578 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | P2RY6 (Homo sapiens) | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of P2RY6 mRNA | CTD | PMID:29704546 | 2,4,6-trinitrotoluene | affects expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Trinitrotoluene affects the expression of P2RY6 mRNA | CTD | PMID:21346803 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of P2RY6 mRNA | CTD | PMID:30951980 | acetamide | increases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of P2RY6 mRNA | CTD | PMID:31881176 | aflatoxin B1 | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of P2RY6 mRNA | CTD | PMID:22100608 | aflatoxin B1 | increases methylation | ISO | P2RY6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of P2RY6 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of P2RY6 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of P2RY6 mRNA | CTD | PMID:16483693 | antirheumatic drug | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of P2RY6 mRNA | CTD | PMID:24449571 | arsane | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Arsenic results in increased expression of P2RY6 mRNA | CTD | PMID:36861143 | arsenic atom | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Arsenic results in increased expression of P2RY6 mRNA | CTD | PMID:36861143 | ATP | multiple interactions | ISO | P2RY6 (Homo sapiens) | 6480464 | N more ... | CTD | PMID:22129738 | benzo[a]pyrene | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of P2RY6 mRNA | CTD | PMID:20064835 and PMID:22316170 | benzo[a]pyrene | affects methylation | ISO | P2RY6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of P2RY6 5' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of P2RY6 mRNA | CTD | PMID:22228805 and PMID:23735875 | benzo[e]pyrene | increases methylation | ISO | P2RY6 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of P2RY6 intron | CTD | PMID:30157460 | Benzo[k]fluoranthene | increases expression | EXP | | 6480464 | benzo(k)fluoranthene results in increased expression of P2RY6 mRNA | CTD | PMID:26377693 | bis(2-ethylhexyl) phthalate | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of P2RY6 mRNA | CTD | PMID:31163220 | bisphenol A | increases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of P2RY6 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of P2RY6 mRNA | CTD | PMID:29718440 | cadmium atom | multiple interactions | ISO | P2RY6 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of P2RY6 mRNA | CTD | PMID:35301059 | cadmium atom | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Cadmium results in increased expression of P2RY6 mRNA | CTD | PMID:33194959 | cadmium dichloride | multiple interactions | ISO | P2RY6 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of P2RY6 mRNA | CTD | PMID:35301059 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | P2RY6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to P2RY6 gene] | CTD | PMID:28238834 | chloroprene | decreases expression | EXP | | 6480464 | Chloroprene results in decreased expression of P2RY6 mRNA | CTD | PMID:23125180 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of P2RY6 mRNA | CTD | PMID:20938992 | cisplatin | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of P2RY6 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | P2RY6 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of P2RY6 mRNA | CTD | PMID:27392435 | copper atom | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Copper results in increased expression of P2RY6 mRNA | CTD | PMID:19747488 | copper(0) | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Copper results in increased expression of P2RY6 mRNA | CTD | PMID:19747488 | copper(II) sulfate | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of P2RY6 mRNA | CTD | PMID:19549813 | crocidolite asbestos | increases expression | EXP | | 6480464 | Asbestos and Crocidolite results in increased expression of P2RY6 mRNA | CTD | PMID:23917077 | Cuprizon | increases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of P2RY6 mRNA | CTD | PMID:27523638 | dextran sulfate | multiple interactions | EXP | | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of P2RY6 mRNA | CTD | PMID:29950665 | dibutyl phthalate | decreases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in decreased expression of P2RY6 mRNA | CTD | PMID:21266533 | dicrotophos | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of P2RY6 mRNA | CTD | PMID:28302478 | dioxygen | multiple interactions | EXP | | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of P2RY6 mRNA | CTD | PMID:30529165 | doxorubicin | affects response to substance | ISO | P2RY6 (Homo sapiens) | 6480464 | P2RY6 mRNA affects the susceptibility to Doxorubicin | CTD | PMID:16044152 | doxorubicin | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of P2RY6 mRNA | CTD | PMID:29803840 | endosulfan | affects expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Endosulfan affects the expression of P2RY6 mRNA | CTD | PMID:29391264 | ethanol | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of P2RY6 mRNA | CTD | PMID:30517762 | folic acid | multiple interactions | EXP | | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | furan | increases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | furan results in increased expression of P2RY6 mRNA | CTD | PMID:27387713 | hydrogen peroxide | affects expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of P2RY6 mRNA | CTD | PMID:20044591 | hydrogen peroxide | multiple interactions | ISO | P2RY6 (Homo sapiens) | 6480464 | N more ... | CTD | PMID:22129738 | hydroxyurea | increases expression | EXP | | 6480464 | Hydroxyurea results in increased expression of P2RY6 mRNA | CTD | PMID:27208086 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of P2RY6 mRNA | CTD | PMID:20938992 | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of P2RY6 mRNA | CTD | PMID:21829687 | Licochalcone B | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | licochalcone B results in decreased expression of P2RY6 mRNA | CTD | PMID:33647349 | lipopolysaccharide | increases expression | EXP | | 6480464 | Lipopolysaccharides results in increased expression of P2RY6 mRNA | CTD | PMID:27339419 | lipopolysaccharide | multiple interactions | EXP | | 6480464 | P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]] and P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] | CTD | PMID:18523137 | methapyrilene | increases methylation | ISO | P2RY6 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of P2RY6 intron | CTD | PMID:30157460 | nickel atom | increases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Nickel results in increased expression of P2RY6 mRNA | CTD | PMID:24768652 and PMID:25583101 | niclosamide | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Niclosamide results in decreased expression of P2RY6 mRNA | CTD | PMID:36318118 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of P2RY6 mRNA | CTD | PMID:17562736 | perfluorohexanesulfonic acid | increases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in increased expression of P2RY6 mRNA | CTD | PMID:37995155 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of P2RY6 mRNA | CTD | PMID:17426115 | quercitrin | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | quercitrin results in decreased expression of P2RY6 mRNA | CTD | PMID:25193878 | silicon dioxide | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of P2RY6 mRNA | CTD | PMID:25895662 | silicon dioxide | increases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Silicon Dioxide results in increased expression of P2RY6 mRNA | CTD | PMID:32721576 | silver atom | decreases expression | EXP | | 6480464 | Silver results in decreased expression of P2RY6 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | EXP | | 6480464 | Silver results in decreased expression of P2RY6 mRNA | CTD | PMID:27131904 | sinapic acid | decreases expression | EXP | | 6480464 | sinapinic acid analog results in decreased expression of P2RY6 mRNA | CTD | PMID:36279966 | sodium dichromate | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | sodium bichromate results in decreased expression of P2RY6 mRNA | CTD | PMID:17685462 | sulforaphane | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of P2RY6 mRNA | CTD | PMID:31838189 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of P2RY6 mRNA | CTD | PMID:27339419 | tetrachloromethane | multiple interactions | ISO | P2ry6 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of P2RY6 mRNA] | CTD | PMID:31150632 | tetrachloromethane | decreases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of P2RY6 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of P2RY6 mRNA | CTD | PMID:30517762 | thioacetamide | increases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of P2RY6 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of P2RY6 mRNA | CTD | PMID:23557971 | titanium dioxide | multiple interactions | EXP | | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of P2RY6 mRNA | CTD | PMID:29950665 | trichloroethene | decreases expression | ISO | P2ry6 (Rattus norvegicus) | 6480464 | Trichloroethylene results in decreased expression of P2RY6 mRNA | CTD | PMID:33387578 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of P2RY6 mRNA | CTD | PMID:33045310 | UDP | multiple interactions | EXP | | 6480464 | P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]] more ... | CTD | PMID:18523137 | UDP | affects response to substance | EXP | | 6480464 | P2RY6 gene affects the susceptibility to Uridine Diphosphate | CTD | PMID:18523137 | urethane | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Urethane results in decreased expression of P2RY6 mRNA | CTD | PMID:28818685 | zinc atom | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Zinc results in decreased expression of P2RY6 mRNA | CTD | PMID:18316168 | zinc(0) | decreases expression | ISO | P2RY6 (Homo sapiens) | 6480464 | Zinc results in decreased expression of P2RY6 mRNA | CTD | PMID:18316168 | |