STX4 (syntaxin 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: STX4 (syntaxin 4) Homo sapiens
Analyze
Symbol: STX4
Name: syntaxin 4
RGD ID: 731468
HGNC Page HGNC:11439
Description: Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. Implicated in autosomal recessive nonsyndromic deafness.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DFNB123; LOC101928762; p35-2; renal carcinoma antigen NY-REN-31; STX4A; syntaxin 4A (placental); syntaxin-4; uncharacterized LOC101928762
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,033,095 - 31,040,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,032,889 - 31,042,975 (+)EnsemblGRCh38hg38GRCh38
GRCh371631,044,416 - 31,051,489 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,952,404 - 30,958,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341630,952,403 - 30,958,985NCBI
Celera1629,246,015 - 29,253,171 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,606,302 - 28,613,331 (+)NCBIHuRef
CHM1_11632,361,656 - 32,368,735 (+)NCBICHM1_1
T2T-CHM13v2.01631,420,532 - 31,430,402 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. The GLUT4 code. Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
Additional References at PubMed
PMID:7690687   PMID:7768895   PMID:7791877   PMID:8206394   PMID:8663154   PMID:8760387   PMID:8770861   PMID:8973549   PMID:9045631   PMID:9168999   PMID:9815132   PMID:9852078  
PMID:10194441   PMID:10394363   PMID:10397765   PMID:10508479   PMID:10713150   PMID:10820264   PMID:10856305   PMID:11031247   PMID:11063739   PMID:11252894   PMID:11842301   PMID:11880646  
PMID:11884531   PMID:11994746   PMID:12130530   PMID:12145319   PMID:12417022   PMID:12435603   PMID:12477932   PMID:12517971   PMID:12556468   PMID:12558796   PMID:12651853   PMID:12773094  
PMID:12828989   PMID:12832401   PMID:12853575   PMID:12855681   PMID:14702039   PMID:14993220   PMID:15184072   PMID:15351710   PMID:15489334   PMID:15576373   PMID:16189514   PMID:16339081  
PMID:16677249   PMID:18029348   PMID:18535201   PMID:18588921   PMID:18793635   PMID:19546860   PMID:19738201   PMID:20434989   PMID:20458337   PMID:20595382   PMID:20956541   PMID:20959521  
PMID:21393240   PMID:21516116   PMID:21720706   PMID:21873635   PMID:22153078   PMID:22226963   PMID:22558309   PMID:22939629   PMID:23246001   PMID:23376485   PMID:24055037   PMID:24146186  
PMID:24552216   PMID:24623722   PMID:24711643   PMID:24807903   PMID:25416956   PMID:25468996   PMID:25673907   PMID:25762204   PMID:25910212   PMID:26186194   PMID:27107014   PMID:27530212  
PMID:27662481   PMID:28514442   PMID:28524818   PMID:28624237   PMID:28798239   PMID:29180619   PMID:29358308   PMID:29360461   PMID:29892012   PMID:29896202   PMID:29997244   PMID:30217970  
PMID:30639242   PMID:30833792   PMID:31515488   PMID:31871319   PMID:32296183   PMID:32913203   PMID:33845483   PMID:33961781   PMID:34079125   PMID:34373451   PMID:34482824   PMID:34706264  
PMID:35253629   PMID:35271311   PMID:35337019   PMID:35748872   PMID:35831314   PMID:36215168   PMID:36300783   PMID:36355422   PMID:36610398   PMID:36724073   PMID:37885878   PMID:38136609  


Genomics

Comparative Map Data
STX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,033,095 - 31,040,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,032,889 - 31,042,975 (+)EnsemblGRCh38hg38GRCh38
GRCh371631,044,416 - 31,051,489 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,952,404 - 30,958,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341630,952,403 - 30,958,985NCBI
Celera1629,246,015 - 29,253,171 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,606,302 - 28,613,331 (+)NCBIHuRef
CHM1_11632,361,656 - 32,368,735 (+)NCBICHM1_1
T2T-CHM13v2.01631,420,532 - 31,430,402 (+)NCBIT2T-CHM13v2.0
Stx4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,439,832 - 127,450,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,423,466 - 127,448,191 (+)EnsemblGRCm39 Ensembl
GRCm387127,840,643 - 127,850,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,824,294 - 127,849,019 (+)EnsemblGRCm38mm10GRCm38
MGSCv377134,985,322 - 134,992,493 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,632,956 - 127,640,127 (+)NCBIMGSCv36mm8
Celera7127,676,765 - 127,683,936 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.77NCBI
Stx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,880,549 - 191,890,333 (+)NCBIGRCr8
mRatBN7.21182,451,108 - 182,459,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,451,117 - 182,459,979 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,802,134 - 190,809,219 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,988,229 - 197,995,314 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,658,604 - 190,665,673 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,287,384 - 199,295,606 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,287,710 - 199,294,979 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,309,816 - 206,318,028 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,125,847 - 187,132,932 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,275,727 - 187,282,813 (+)NCBI
Celera1180,102,717 - 180,109,811 (+)NCBICelera
Cytogenetic Map1q37NCBI
STX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,239,001 - 34,257,513 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,042,394 - 39,058,935 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,917,576 - 23,933,884 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,400,189 - 31,407,547 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,400,915 - 31,411,364 (+)Ensemblpanpan1.1panPan2
STX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,184,044 - 17,189,481 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,184,399 - 17,189,370 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,759,405 - 18,764,838 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,314,720 - 17,320,111 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,314,723 - 17,320,127 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,115,083 - 17,120,474 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,034,169 - 17,039,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,346,511 - 17,351,885 (-)NCBIUU_Cfam_GSD_1.0
Stx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,303,930 - 125,310,459 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,401,989 - 13,408,325 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,401,095 - 13,408,316 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,416,842 - 17,431,053 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,422,266 - 17,431,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,752,907 - 17,761,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,725,121 - 27,734,442 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,724,495 - 27,732,736 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,739,403 - 1,746,068 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,090,850 - 14,105,058 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,094,727 - 14,101,210 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in STX4
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p11.2-11.1(chr16:30691912-36160463)x3 copy number gain See cases [RCV000133811] Chr16:30691912..36160463 [GRCh38]
Chr16:30703233..35147508 [GRCh37]
Chr16:30610734..35005009 [NCBI36]
Chr16:16p11.2-11.1		 pathogenic
GRCh38/hg38 16p11.2(chr16:29909613-31438697)x3 copy number gain See cases [RCV000135339] Chr16:29909613..31438697 [GRCh38]
Chr16:29920934..31450018 [GRCh37]
Chr16:29828435..31357519 [NCBI36]
Chr16:16p11.2		 pathogenic
GRCh38/hg38 16p12.1-11.2(chr16:27311746-31193406)x3 copy number gain See cases [RCV000140341] Chr16:27311746..31193406 [GRCh38]
Chr16:27323067..31204727 [GRCh37]
Chr16:27230568..31112228 [NCBI36]
Chr16:16p12.1-11.2		 pathogenic
GRCh38/hg38 16p11.2(chr16:30960404-31066796)x1 copy number loss See cases [RCV000139523] Chr16:30960404..31066796 [GRCh38]
Chr16:30971725..31078117 [GRCh37]
Chr16:30879226..30985618 [NCBI36]
Chr16:16p11.2		 likely benign
GRCh38/hg38 16p12.2-11.2(chr16:23752047-31943755)x3 copy number gain See cases [RCV000141141] Chr16:23752047..31943755 [GRCh38]
Chr16:23763368..31955076 [GRCh37]
Chr16:23670869..31862577 [NCBI36]
Chr16:16p12.2-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:30391304-31122666)x3 copy number gain Breast ductal adenocarcinoma [RCV000207028] Chr16:30391304..31122666 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
Single allele deletion Branched-chain keto acid dehydrogenase kinase deficiency [RCV000735205] Chr16:30554158..31536880 [GRCh37]
Chr16:16p11.2		 uncertain significance
NC_000016.10:g.(?_30992801)_(31068051_?)del deletion Generalized epilepsy with febrile seizures plus, type 9 [RCV000558002] Chr16:30992801..31068051 [GRCh38]
Chr16:31004122..31079372 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:30943854-31171177)x1 copy number loss See cases [RCV000446201] Chr16:30943854..31171177 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p11.2(chr16:30830287-31827011)x4 copy number gain See cases [RCV000447708] Chr16:30830287..31827011 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:28826162-29043901)x1 copy number loss See cases [RCV000448084] Chr16:28826162..29043901 [GRCh37]
Chr16:16p11.2		 likely pathogenic
GRCh37/hg19 16p11.2(chr16:30952806-31177641)x1 copy number loss See cases [RCV000511906] Chr16:30952806..31177641 [GRCh37]
Chr16:16p11.2		 likely pathogenic
GRCh37/hg19 16p11.2(chr16:30607048-31117069)x1 copy number loss See cases [RCV000511454] Chr16:30607048..31117069 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
NM_004604.5(STX4):c.107G>T (p.Ser36Ile) single nucleotide variant not specified [RCV004314195] Chr16:31034089 [GRCh38]
Chr16:31045410 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p11.2(chr16:30738551-34194635)x3 copy number gain not provided [RCV000739123] Chr16:30738551..34194635 [GRCh37]
Chr16:16p11.2		 benign
GRCh37/hg19 16p11.2(chr16:30851860-31156762)x1 copy number loss not provided [RCV000848082] Chr16:30851860..31156762 [GRCh37]
Chr16:16p11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p11.2(chr16:30350747-31905898)x3 copy number gain not provided [RCV001258619] Chr16:30350747..31905898 [GRCh37]
Chr16:16p11.2		 uncertain significance
GRCh37/hg19 16p11.2(chr16:30943854-31171177) copy number loss not specified [RCV002052525] Chr16:30943854..31171177 [GRCh37]
Chr16:16p11.2		 likely pathogenic
NM_004604.5(STX4):c.232+6T>C single nucleotide variant Hearing loss, autosomal recessive 123 [RCV003883471]|Sensorineural hearing loss disorder [RCV002291511] Chr16:31034331 [GRCh38]
Chr16:31045652 [GRCh37]
Chr16:16p11.2		 pathogenic|likely pathogenic
NM_004604.5(STX4):c.179A>G (p.Gln60Arg) single nucleotide variant not specified [RCV004217147] Chr16:31034272 [GRCh38]
Chr16:31045593 [GRCh37]
Chr16:16p11.2		 likely benign
NM_004604.5(STX4):c.697A>C (p.Met233Leu) single nucleotide variant not specified [RCV004089029] Chr16:31038642 [GRCh38]
Chr16:31049963 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_004604.5(STX4):c.403G>A (p.Val135Met) single nucleotide variant not specified [RCV004198747] Chr16:31037950 [GRCh38]
Chr16:31049271 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_004604.5(STX4):c.289A>G (p.Ile97Val) single nucleotide variant not specified [RCV004071277] Chr16:31034518 [GRCh38]
Chr16:31045839 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_004604.5(STX4):c.352G>A (p.Val118Ile) single nucleotide variant not specified [RCV004089798] Chr16:31035014 [GRCh38]
Chr16:31046335 [GRCh37]
Chr16:16p11.2		 likely benign
NM_004604.5(STX4):c.718C>T (p.Arg240Trp) single nucleotide variant not provided [RCV003881722] Chr16:31039556 [GRCh38]
Chr16:31050877 [GRCh37]
Chr16:16p11.2		 uncertain significance
NM_004604.5(STX4):c.74T>C (p.Leu25Pro) single nucleotide variant not specified [RCV004458633] Chr16:31034056 [GRCh38]
Chr16:31045377 [GRCh37]
Chr16:16p11.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4858
Count of miRNA genes:970
Interacting mature miRNAs:1198
Transcripts:ENST00000313843, ENST00000394998, ENST00000457779, ENST00000460668, ENST00000461455, ENST00000468583, ENST00000475862, ENST00000478150, ENST00000486660, ENST00000487411, ENST00000493902, ENST00000496977, ENST00000503629, ENST00000564368, ENST00000565483, ENST00000566353
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH48799  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,045,951 - 31,046,136UniSTSGRCh37
Build 361630,953,452 - 30,953,637RGDNCBI36
Celera1629,251,938 - 29,252,123RGD
Cytogenetic Map16p11.2UniSTS
HuRef1628,607,837 - 28,608,022UniSTS
RH11484  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,051,233 - 31,051,365UniSTSGRCh37
Build 361630,958,734 - 30,958,866RGDNCBI36
Celera1629,246,135 - 29,246,267RGD
Cytogenetic Map16p11.2UniSTS
HuRef1628,613,075 - 28,613,207UniSTS
SHGC-146535  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,050,039 - 31,050,327UniSTSGRCh37
Build 361630,957,540 - 30,957,828RGDNCBI36
Celera1629,247,173 - 29,247,461RGD
Cytogenetic Map16p11.2UniSTS
HuRef1628,611,881 - 28,612,169UniSTS
TNG Radiation Hybrid Map1617320.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2427 2731 1687 585 1895 428 4313 1975 3166 391 1443 1596 170 1204 2752 3
Low 12 260 39 39 56 37 44 222 568 28 17 17 5 1 36 3 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001272095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001272096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005255521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054313785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001752117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008484727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008484728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008484729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008484730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_243383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC135050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF026007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF318489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI755734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ775670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X85784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000313843   ⟹   ENSP00000317714
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,558 - 31,040,164 (+)Ensembl
RefSeq Acc Id: ENST00000394998   ⟹   ENSP00000378447
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,095 - 31,040,163 (+)Ensembl
RefSeq Acc Id: ENST00000457779   ⟹   ENSP00000390788
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,032,889 - 31,035,032 (+)Ensembl
RefSeq Acc Id: ENST00000460668   ⟹   ENSP00000454419
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,547 - 31,038,187 (+)Ensembl
RefSeq Acc Id: ENST00000461455
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,588 - 31,034,877 (+)Ensembl
RefSeq Acc Id: ENST00000468583
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,038,619 - 31,040,168 (+)Ensembl
RefSeq Acc Id: ENST00000475862
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,038,601 - 31,040,168 (+)Ensembl
RefSeq Acc Id: ENST00000478150
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,786 - 31,034,507 (+)Ensembl
RefSeq Acc Id: ENST00000486660
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,038,510 - 31,040,012 (+)Ensembl
RefSeq Acc Id: ENST00000487411
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,546 - 31,039,803 (+)Ensembl
RefSeq Acc Id: ENST00000493902
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,095 - 31,040,129 (+)Ensembl
RefSeq Acc Id: ENST00000496977   ⟹   ENSP00000454841
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,547 - 31,038,647 (+)Ensembl
RefSeq Acc Id: ENST00000503629
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,039,080 - 31,042,975 (+)Ensembl
RefSeq Acc Id: ENST00000564368
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,039,320 - 31,040,147 (+)Ensembl
RefSeq Acc Id: ENST00000565483
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,606 - 31,034,853 (+)Ensembl
RefSeq Acc Id: ENST00000566353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,557 - 31,039,747 (+)Ensembl
RefSeq Acc Id: ENST00000613541   ⟹   ENSP00000480544
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1631,033,805 - 31,034,877 (+)Ensembl
RefSeq Acc Id: NM_001272095   ⟹   NP_001259024
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,033,491 - 31,040,168 (+)NCBI
GRCh371631,044,416 - 31,051,489 (+)NCBI
HuRef1628,606,302 - 28,613,331 (+)NCBI
CHM1_11632,362,052 - 32,368,735 (+)NCBI
T2T-CHM13v2.01631,420,928 - 31,427,606 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001272096   ⟹   NP_001259025
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,033,095 - 31,040,168 (+)NCBI
GRCh371631,044,416 - 31,051,489 (+)NCBI
HuRef1628,606,302 - 28,613,331 (+)NCBI
CHM1_11632,361,656 - 32,368,735 (+)NCBI
T2T-CHM13v2.01631,420,532 - 31,427,606 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004604   ⟹   NP_004595
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,033,558 - 31,040,164 (+)NCBI
GRCh371631,044,416 - 31,051,489 (+)NCBI
Build 361630,952,404 - 30,958,986 (+)NCBI Archive
HuRef1628,606,302 - 28,613,331 (+)NCBI
CHM1_11632,362,052 - 32,368,735 (+)NCBI
T2T-CHM13v2.01631,420,995 - 31,427,602 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005255521   ⟹   XP_005255578
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,033,491 - 31,040,168 (+)NCBI
GRCh371631,044,416 - 31,051,489 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047434542   ⟹   XP_047290498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,033,491 - 31,038,193 (+)NCBI
RefSeq Acc Id: XM_047434543   ⟹   XP_047290499
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,035,738 - 31,040,168 (+)NCBI
RefSeq Acc Id: XM_054313784   ⟹   XP_054169759
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01631,420,928 - 31,427,606 (+)NCBI
RefSeq Acc Id: XM_054313785   ⟹   XP_054169760
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01631,420,928 - 31,425,631 (+)NCBI
RefSeq Acc Id: XR_008484727
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01631,420,928 - 31,430,402 (+)NCBI
RefSeq Acc Id: XR_008484728
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01631,420,928 - 31,430,402 (+)NCBI
RefSeq Acc Id: XR_008484729
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01631,420,928 - 31,430,402 (+)NCBI
RefSeq Acc Id: XR_008484730
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01631,423,175 - 31,430,402 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_004595   ⟸   NM_004604
- Peptide Label: isoform 3
- UniProtKB: Q15525 (UniProtKB/Swiss-Prot),   A8MXY0 (UniProtKB/Swiss-Prot),   Q6FHE8 (UniProtKB/Swiss-Prot),   Q12846 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001259025   ⟸   NM_001272096
- Peptide Label: isoform 2
- UniProtKB: Q12846 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001259024   ⟸   NM_001272095
- Peptide Label: isoform 1
- UniProtKB: B7Z425 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005255578   ⟸   XM_005255521
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000480544   ⟸   ENST00000613541
RefSeq Acc Id: ENSP00000454841   ⟸   ENST00000496977
RefSeq Acc Id: ENSP00000390788   ⟸   ENST00000457779
RefSeq Acc Id: ENSP00000317714   ⟸   ENST00000313843
RefSeq Acc Id: ENSP00000378447   ⟸   ENST00000394998
RefSeq Acc Id: ENSP00000454419   ⟸   ENST00000460668
RefSeq Acc Id: XP_047290498   ⟸   XM_047434542
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047290499   ⟸   XM_047434543
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054169759   ⟸   XM_054313784
- Peptide Label: isoform X4
- UniProtKB: Q15525 (UniProtKB/Swiss-Prot),   Q12846 (UniProtKB/Swiss-Prot),   A8MXY0 (UniProtKB/Swiss-Prot),   Q6FHE8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054169760   ⟸   XM_054313785
- Peptide Label: isoform X2
Protein Domains
Syntaxin N-terminal   t-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q12846-F1-model_v2 AlphaFold Q12846 1-297 view protein structure

Promoters
RGD ID:6793488
Promoter ID:HG_KWN:23591
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000255538,   OTTHUMT00000317180,   OTTHUMT00000317182,   OTTHUMT00000317183,   OTTHUMT00000317184,   OTTHUMT00000317185,   OTTHUMT00000317186,   OTTHUMT00000317187,   UC002EAK.1,   UC002EAM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361630,951,666 - 30,952,522 (+)MPROMDB
RGD ID:7232049
Promoter ID:EPDNEW_H21770
Type:initiation region
Name:STX4_1
Description:syntaxin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21771  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,033,558 - 31,033,618EPDNEW
RGD ID:7232051
Promoter ID:EPDNEW_H21771
Type:initiation region
Name:STX4_2
Description:syntaxin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21770  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,033,742 - 31,033,802EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11439 AgrOrtholog
COSMIC STX4 COSMIC
Ensembl Genes ENSG00000103496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000313843 ENTREZGENE
  ENST00000313843.8 UniProtKB/Swiss-Prot
  ENST00000394998 ENTREZGENE
  ENST00000394998.5 UniProtKB/Swiss-Prot
  ENST00000457779.6 UniProtKB/TrEMBL
  ENST00000460668.5 UniProtKB/TrEMBL
  ENST00000496977.5 UniProtKB/TrEMBL
  ENST00000613541.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000103496 GTEx
HGNC ID HGNC:11439 ENTREZGENE
Human Proteome Map STX4 Human Proteome Map
InterPro SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin/epimorphin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6810 UniProtKB/Swiss-Prot
NCBI Gene 6810 ENTREZGENE
OMIM 186591 OMIM
PANTHER PTHR19957 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNTAXIN-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36236 PharmGKB
PROSITE SYNTAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SynN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  t_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WWW0_HUMAN UniProtKB/TrEMBL
  A8MXY0 ENTREZGENE
  B7Z425 ENTREZGENE, UniProtKB/TrEMBL
  C9JFM5_HUMAN UniProtKB/TrEMBL
  H3BMK2_HUMAN UniProtKB/TrEMBL
  Q12846 ENTREZGENE
  Q15525 ENTREZGENE
  Q6FHE8 ENTREZGENE
  STX4_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A8MXY0 UniProtKB/Swiss-Prot
  Q15525 UniProtKB/Swiss-Prot
  Q6FHE8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-12-14 STX4  syntaxin 4  LOC101928762  uncharacterized LOC101928762  Data Merged 737654 PROVISIONAL