Bmp15 (bone morphogenetic protein 15)

Gene: Bmp15 (bone morphogenetic protein 15) Mus musculus

Analyze

Symbol:

Bmp15

Name:

bone morphogenetic protein 15

RGD ID:

730934

MGI Page

MGI

Description:

Predicted to enable cytokine activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in cytoplasm. Is expressed in several structures, including central nervous system; early conceptus; metanephros; and oocyte. Human ortholog(s) of this gene implicated in ovarian dysgenesis 2 and primary ovarian insufficiency. Orthologous to human BMP15 (bone morphogenetic protein 15).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

AU015375; AU018861; AU021453; Bmp-1; Bmp-15; C86824; C87336; GDF-9B; growth/differentiation factor 9B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BMP15 (bone morphogenetic protein 15)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Bmp15 (bone morphogenetic protein 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bmp15 (bone morphogenetic protein 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BMP15 (bone morphogenetic protein 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BMP15 (bone morphogenetic protein 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bmp15 (bone morphogenetic protein 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BMP15 (bone morphogenetic protein 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BMP15 (bone morphogenetic protein 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bmp15 (bone morphogenetic protein 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Bmp15 (bone morphogenetic protein 15)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BMP15 (bone morphogenetic protein 15)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bmp15 (bone morphogenetic protein 15)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid\|ZFIN)
Xenopus tropicalis (tropical clawed frog):	bmp15	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	6,226,108 - 6,232,778 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	6,226,161 - 6,232,775 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	6,314,054 - 6,320,724 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	6,314,107 - 6,320,721 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	5,891,224 - 5,897,841 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	5,489,598 - 5,496,190 (-)	NCBI		MGSCv36	mm8
Celera	X	5,090,389 - 5,097,007 (+)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	2.81	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

autistic disorder (ISO)

congenital disorder of glycosylation type IIm (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (ISO)

neurodegeneration with brain iron accumulation 5 (ISO)

ovarian dysgenesis 2 (ISO)

polycystic ovary syndrome (ISO)

Postmenopausal Osteoporosis (ISO)

primary ovarian insufficiency (ISO)

primary ovarian insufficiency 16 (ISO)

Stocco Dos Santos type X-linked intellectual disability (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked epilepsy with variable learning disabilities and behavior disorders (ISO)

X-linked severe congenital neutropenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (EXP)

5-azacytidine (EXP)

alpha-naphthoflavone (ISO)

ammonium chloride (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

Chloroacetonitrile (EXP)

chlorothalonil (EXP)

chlorpyrifos (EXP)

copper atom (ISO)

copper(0) (ISO)

decabromodiphenyl ether (ISO)

dimethomorph (ISO)

glycidol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

progesterone (ISO)

resveratrol (ISO)

sodium arsenite (EXP)

Theaflavin 3,3'-digallate (EXP)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ovarian cumulus expansion (ISO)

positive regulation of DNA-templated transcription (ISO)

Cellular Component

cytoplasm (IDA)

extracellular region (IEA)

extracellular space (IBA)

Molecular Function

cytokine activity (IBA)

growth factor activity (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal oocyte morphology (IAGP)

abnormal ovarian folliculogenesis (IAGP)

abnormal ovary morphology (IAGP)

abnormal zona pellucida morphology (IAGP)

absent corpus luteum (IAGP)

absent cumulus expansion (IAGP)

absent oocytes (IAGP)

decreased litter size (IAGP)

decreased mature ovarian follicle number (IAGP)

decreased oocyte number (IAGP)

decreased superovulation rate (IAGP)

female infertility (IAGP)

impaired ovarian folliculogenesis (IAGP)

ovary cyst (IAGP)

polyovular ovarian follicle (IAGP)

reduced female fertility (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Missense mutations in the BMP15 gene are associated with ovarian failure.	Dixit H, etal., Hum Genet. 2006 May;119(4):408-15. Epub 2006 Mar 1.
2.	Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.	Galloway SM, etal., Nat Genet 2000 Jul;25(3):279-83.
3.	Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.	Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4.	Estrogen-related genes and postmenopausal osteoporosis risk.	Mendoza N, etal., Climacteric. 2012 Dec;15(6):587-93. doi: 10.3109/13697137.2012.656160. Epub 2012 Feb 15.
5.	MGDs mouse GO annotations	MGD data from the GO Consortium
6.	MGD IEA	MGD IEA
7.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9849956	PMID:9858711	PMID:10349636	PMID:10612437	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11376106	PMID:12446622	PMID:12477932	PMID:12666204
PMID:12887271	PMID:12912906	PMID:15326356	PMID:15342483	PMID:15489334	PMID:15531364	PMID:15809424	PMID:16141072	PMID:16141073	PMID:16537572	PMID:16602821	PMID:16818886
PMID:16943361	PMID:17015433	PMID:17553902	PMID:18045843	PMID:18633140	PMID:19480014	PMID:19553355	PMID:19553596	PMID:20382892	PMID:20702851	PMID:20857181	PMID:21047911
PMID:21226076	PMID:21267068	PMID:21731673	PMID:21873635	PMID:21911477	PMID:22847922	PMID:23233153	PMID:23382188	PMID:24357321	PMID:24548471	PMID:24952961	PMID:25100713
PMID:25416550	PMID:25810521	PMID:26254468	PMID:26267271	PMID:27050391	PMID:30060157	PMID:30302808	PMID:30352686	PMID:31657143	PMID:33824958	PMID:35104175	PMID:36424497

Genomics

Comparative Map Data

Bmp15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	6,226,108 - 6,232,778 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	6,226,161 - 6,232,775 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	6,314,054 - 6,320,724 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	6,314,107 - 6,320,721 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	5,891,224 - 5,897,841 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	5,489,598 - 5,496,190 (-)	NCBI		MGSCv36	mm8
Celera	X	5,090,389 - 5,097,007 (+)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	2.81	NCBI

BMP15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	50,910,735 - 50,916,641 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	50,910,735 - 50,916,641 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	50,653,735 - 50,659,641 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	50,670,524 - 50,676,347 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	50,486,819 - 50,492,643	NCBI
Celera	X	54,697,190 - 54,703,096 (+)	NCBI		Celera
Cytogenetic Map	X	p11.22	NCBI
HuRef	X	48,097,311 - 48,103,406 (+)	NCBI		HuRef
CHM1_1	X	50,733,338 - 50,739,244 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	50,181,955 - 50,187,861 (+)	NCBI		T2T-CHM13v2.0

Bmp15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	18,840,943 - 18,846,006 (+)	NCBI		GRCr8
mRatBN7.2	X	16,169,123 - 16,174,187 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	16,169,123 - 16,174,187 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	20,981,822 - 20,986,886 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	19,096,380 - 19,101,444 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	15,361,328 - 15,366,392 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	17,016,831 - 17,021,894 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	17,016,778 - 17,023,418 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	17,797,360 - 17,802,423 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	29,003,933 - 29,008,996 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	29,057,401 - 29,062,465 (-)	NCBI
Celera	X	16,238,220 - 16,243,279 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

Bmp15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955543	2,339,659 - 2,345,406 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955543	2,304,112 - 2,345,376 (+)	NCBI	ChiLan1.0	ChiLan1.0

BMP15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	52,284,905 - 52,291,966 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	52,288,509 - 52,295,570 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	43,071,039 - 43,076,941 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	50,783,925 - 50,789,830 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	50,783,925 - 50,791,369 (+)	Ensembl	panpan1.1		panPan2

BMP15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	43,765,126 - 43,771,277 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	43,764,777 - 43,771,287 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	18,142,461 - 18,147,409 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	43,885,645 - 43,890,593 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	43,885,666 - 43,890,593 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0	X	43,877,414 - 43,882,362 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	43,972,394 - 43,977,342 (+)	NCBI		UU_Cfam_GSD_1.0

Bmp15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	36,301,604 - 36,318,300 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936873	109,156 - 115,498 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BMP15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	44,613,122 - 44,620,575 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	44,613,122 - 44,620,575 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	49,544,707 - 49,550,877 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BMP15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	47,713,434 - 47,722,818 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	47,713,957 - 47,719,777 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666086	1,314,361 - 1,320,255 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bmp15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624893	3,014,989 - 3,021,746 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624893	3,014,535 - 3,020,862 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bmp15
153 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	777
Count of miRNA genes:	490
Interacting mature miRNAs:	590
Transcripts:	ENSMUST00000024049
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1302195	Pbwg10_m	postnatal body weight growth 10 (mouse)			Not determined		X	1	26202173	Mouse

Markers in Region

AU015375

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	6,314,674 - 6,314,913	UniSTS	GRCm38
MGSCv37	X	5,891,792 - 5,892,031	UniSTS	GRCm37
Celera	X	5,096,200 - 5,096,439	UniSTS
Cytogenetic Map	X	A1.1	UniSTS
Whitehead/MRC_RH	X	33.3	UniSTS

C86824

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	6,314,691 - 6,314,922	UniSTS	GRCm38
MGSCv37	X	5,891,809 - 5,892,040	UniSTS	GRCm37
Celera	X	5,096,191 - 5,096,422	UniSTS
Cytogenetic Map	X	A1.1	UniSTS
Whitehead/MRC_RH	X	50.84	UniSTS

RH127288

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	6,314,211 - 6,314,460	UniSTS	GRCm38
MGSCv37	X	5,891,329 - 5,891,578	UniSTS	GRCm37
Celera	X	5,096,653 - 5,096,902	UniSTS
Cytogenetic Map	X	A1.1	UniSTS
Whitehead/MRC_RH	X	55.48	UniSTS

RH136504

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	6,314,179 - 6,314,377	UniSTS	GRCm38
MGSCv37	X	5,891,297 - 5,891,495	UniSTS	GRCm37
Celera	X	5,096,736 - 5,096,934	UniSTS
Cytogenetic Map	X	A1.1	UniSTS

AU021453

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	6,314,179 - 6,314,301	UniSTS	GRCm38
MGSCv37	X	5,891,297 - 5,891,419	UniSTS	GRCm37
Celera	X	5,096,812 - 5,096,934	UniSTS
Cytogenetic Map	X	A1.1	UniSTS
Whitehead/MRC_RH	X	51.25	UniSTS

Bmp15

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	6,315,684 - 6,315,798	UniSTS	GRCm38
MGSCv37	X	5,892,802 - 5,892,916	UniSTS	GRCm37
Celera	X	5,095,314 - 5,095,428	UniSTS
Cytogenetic Map	X	A1.1	UniSTS
cM Map	X	0.5	UniSTS

AF082348

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	6,315,532 - 6,315,612	UniSTS	GRCm38
MGSCv37	X	5,892,650 - 5,892,730	UniSTS	GRCm37
Celera	X	5,095,500 - 5,095,580	UniSTS
Cytogenetic Map	X	A1.1	UniSTS
Whitehead/MRC_RH	X	51.63	UniSTS

Bmp15

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	6,315,920 - 6,316,183	UniSTS	GRCm38
MGSCv37	X	5,893,038 - 5,893,301	UniSTS	GRCm37
Celera	X	5,094,929 - 5,095,192	UniSTS
Cytogenetic Map	X	A1.1	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_009757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC125035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF082348	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ010259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ132406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK028735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK135757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK135882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK136127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK136129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK139773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK139847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK139936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AU019682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC055363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DV644809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000024049 ⟹ ENSMUSP00000024049

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	X	6,226,161 - 6,232,775 (-)	Ensembl
GRCm38.p6 Ensembl	X	6,314,107 - 6,320,721 (-)	Ensembl

RefSeq Acc Id:

NM_009757 ⟹ NP_033887

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	X	6,226,108 - 6,232,778 (-)	NCBI
GRCm38	X	6,314,054 - 6,320,724 (-)	NCBI
MGSCv37	X	5,891,224 - 5,897,841 (-)	RGD
Celera	X	5,090,389 - 5,097,007 (+)	RGD
cM Map	X		ENTREZGENE

Sequence:

show sequence

TGCTTCCTTTTAACCTATTAGATTGGGTGCAGGCCAGGTTCCTGGAATGGGCCTCTTCTCCTCG
GTTACTTTAGCCTGTCTGAGAACTGCTGTGTACTTCCCACCAGTGGGGAGTGGGAAGGGCATGC
TGCCTTGTCCCACTTGCTTTTTCTGTTTGTTTTCATGCCAAGAAGCCTAGTCAGGAGACTCGCT
TTGGCCCAGAAGATTCTCCCACAGGAAGTAAGATAGGGTCTGCCAGTCGGCGTTTCTTTTTATT
TCTTGCCCCGTCTTTGGTATTTGTTAAACCAGGATGTGGAAGAGGTCAGACTGATGTTCTTTGG
ACTTGGTTAGGAATCTGCTGAAAAGCACCAAGCTTTGCAAGATGGCCCTTCTCACAATTCTTAG
AATTCTTTTGTGGGGAGTGGTGCTTTTTATGGAACAGAGGGTCCAAATGGCAAAGCCAGGGTGG
CCCTCCACCGCCCTCCTTGCTGACGACCCTACATTGCCCTCAATTTTGGATCTGGCCAAAGAAG
CCCCTGGCAAGGAGATGAAGCAATGGCCCCAAGGCTATCCCCTGAGGTACATGCTCAAGTTATA
CCATCGTTCGGCTGACCCGCATGGCCATCCAAGGGAGAACCGCACGATTGGAGCGAAAATGGTG
AGGCTGGTAAAGCCGTCGGCCAACACAGTAAGGCCTCCCAGAGGTTCCTGGCATGTACAGACCC
TGGACTTTCCTCTAGCATCAAACCAGGTAGCATACGAACTAATCAGAGCCACTGTGGTTTACCG
CCATCAACTTCATCTAGTTAATTACCATCTCTCCTGCCATGTGGAAACTTGGGTTCCTAAATGC
CGGACCAAGCACTTACCTTCTTCTAAATCGGGTTCCTCAAAGCCTTCTCCCATGTCTAAAGCCT
GGACAGAGATAGATATTACACATTGTATTCAGCAGAAGCTCTGGAATCGCAAGGGACGGAGTGT
TCTTCGCCTCCGCTTCATGTGTCAGCAGCAAAAAGGCAATGAGACTCGTGAGTTCCGGTGGCAT
GGCATGACATCCTTGGATGTTGCCTTCTTGCTACTCTATTTCAATGACACCGATGACAGAGTTC
AGGGTAAACTTCTTGCAAGAGGCCAAGAGGAGTTAACTGATAGGGAATCTTCTTTTCTCATGCG
GAGTGTCCGGCAAGCATGCAGCATTGAATCTGATGCCTCTTGTCCTTCTCAGGAACATGATGGG
TCTGTAAATAACCAGTGTTCCCTCCATCCTTACAAGGTCAGCTTCCACCAACTAGGCTGGGATC
ACTGGATCATTGCTCCTCGTCTCTATACCCCAAATTACTGTAAAGGAATCTGTACTCGGGTATT
ACCCTATGGTCTCAATTCACCCAACCATGCCATCATTCAGAGCCTTGTCAATGAACTAGTGAAT
CACAGTGTACCTCAGCCTTCCTGTGTCCCTTATAATTTTCTTCCTATGAGCATCCTCCTGATTG
AGACCAACGGGAGTATCTTGTACAAGGAGTATGAGGGTATGATTGCCCAGTCCTGTACATGTAG
ATAATAGTGAAGTTGTTGCTATCTCAGGTTTCCCAAGAAGCTATAGATGTTTAAAGAAAACTGT
GTTAAAGCTGGCAGTGATCTACCCAACCTACAGATTCTGTTCCTTATCTTTAAAAAATATATTG
TGCTTATGCTTAAAATATAAGAGCCCTTTGTACTCTATAAACAAAATGCTAGGATCCCATCTTA
ATATTTTTTAAAAGTAATTTAAAATACCATGAAATGGTTATCTTAAGCATTGTTTAAATCTCTC
ACCCCATTTTTGAGCTCCTCAGCTTGTAAAAATGTTTCTGGTGCTGGTATCCTAGCATGGATCA
GTAGAACTTAACTAGCCCCCAATACTGAGATAAGATGCTTTCTGGAGATACATTATTACATCAT
TTTTATTGTGACTTTGGGAAAAAAAATCAAGAAAATACTGGTCCATGGTAGAAGAACATATGGA
GTCCTGGAGGTGACTTCATTCTGGGCTCACTTGATTGATGTGTCCAGTTGGGCTCTTCTGGGCT
TAGGTCTCTGGGAGACAACCTTGCTGTTTGGGAGGAAGTATAGAGCTCTTTCTTGAACTAAATT
ATGTTCACAGGATGATTTCTTGTTTTTTTCCCTGTTTTTTTTGTTTTGGATTATTATTATTATT
ATTATTTTGTGCTGAGAATAAGCAAGTGTTCTACCACTGTGCTGTATCCCCAGCCCAGTTTATC
TTCTCTATAATTCTATACTATATTTAAGTGTTGGGACAATATTGCAAATGAATGATGCTTTTTT
TTTTGTTAAAGATCTTGAATGCTTTGGAGATTAGGAGAGAGTGAAAAGAAAGAATTTATATCTT
TTATTCTCTATGGCTATAATCTAGAGCTCTACTTTAATCCCTGAGGGATGGGGCCAGAGGCTCC
TCTGAGTTCTGTCTCAGACAGCACTACTAATAAACAGCTCTTACTAAGGTACTAGTTAAAGAAG
CCCAGCATGTCTCAGTACCTGCCTAGCTATTGACTAGTTTTATCACATTCTCTCTGGGATGGAA
CCTGATTTAGGGCATGGGCATGTGCTCATCATTGTTCATTCCTATCTGTTCCTTACATTTCCCA
TACATTAACTCAGTTATTTCTTTCTCAACAGTTGATGCTCACAGGACTGAATATATGTGGATCT
ATTCCTTAGCATCATTTTGCTCACATATCTACTTAGAAATCAATTCAGGCTTTACTGTTCTTCT
CTTCAGTATTCTCATGACAACCAGTTTCAAGTCGCTGTCTCTCCTCCCATCTCAAAGCACAGCA
TGGTTTCCCTTAAAATGCTCTAGTATTACTGTCTTCACTGAGAAAAGATGGAGCTCCCTTTGAA
CGCTTTACTTGGCTCATTGTCTTCTGAATAGCCAGAACTGAAAACCTAGGAAGTCCTTTGATGA
ATACAAAAAGTTGACTTTTTTGTGTGTGTGAGACATGGAATACCCCCCTATTTATATATTTGTA
TGTTTATGTATTTTCTTAATCTTAAAGAATAAATTTTCATTTATGTGTGCTTTGCATATAAAGT
TAGTAATTTCAAAACTGTACAAATTATAAGAGATGATGAAAGCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_033887	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC99766	(Get FASTA)	NCBI Sequence Viewer
	AAH55363	(Get FASTA)	NCBI Sequence Viewer
	BAC26090	(Get FASTA)	NCBI Sequence Viewer
	BAE22642	(Get FASTA)	NCBI Sequence Viewer
	BAE22833	(Get FASTA)	NCBI Sequence Viewer
	BAE22834	(Get FASTA)	NCBI Sequence Viewer
	BAE24134	(Get FASTA)	NCBI Sequence Viewer
	BAE24158	(Get FASTA)	NCBI Sequence Viewer
	BAE24187	(Get FASTA)	NCBI Sequence Viewer
	CAA09053	(Get FASTA)	NCBI Sequence Viewer
	CAB40966	(Get FASTA)	NCBI Sequence Viewer
	EDL33879	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000024049
	ENSMUSP00000024049.8
GenBank Protein	Q9Z0L4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_033887 ⟸ NM_009757
- Peptide Label:	preproprotein
- UniProtKB:	Q3UT46 (UniProtKB/Swiss-Prot), Q9Z0L4 (UniProtKB/Swiss-Prot), Q3USZ3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALLTILRILLWGVVLFMEQRVQMAKPGWPSTALLADDPTLPSILDLAKEAPGKEMKQWPQGYP LRYMLKLYHRSADPHGHPRENRTIGAKMVRLVKPSANTVRPPRGSWHVQTLDFPLASNQVAYEL IRATVVYRHQLHLVNYHLSCHVETWVPKCRTKHLPSSKSGSSKPSPMSKAWTEIDITHCIQQKL WNRKGRSVLRLRFMCQQQKGNETREFRWHGMTSLDVAFLLLYFNDTDDRVQGKLLARGQEELTD RESSFLMRSVRQACSIESDASCPSQEHDGSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYC KGICTRVLPYGLNSPNHAIIQSLVNELVNHSVPQPSCVPYNFLPMSILLIETNGSILYKEYEGM IAQSCTCR hide sequence

RefSeq Acc Id:

ENSMUSP00000024049 ⟸ ENSMUST00000024049

Protein Domains

TGF-beta family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9Z0L4-F1-model_v2	AlphaFold	Q9Z0L4	1-392	view protein structure

Promoters

RGD ID:

6845533

Promoter ID:

MM_KWN:59372

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lung

Transcripts:

NM_009757

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	X	5,897,346 - 5,897,846 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1316745	AgrOrtholog
Ensembl Genes	ENSMUSG00000023279	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000024049	ENTREZGENE
	ENSMUST00000024049.8	UniProtKB/Swiss-Prot
Gene3D-CATH	2.10.90.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:12155	UniProtKB/Swiss-Prot
MGD	MGI:1316745	ENTREZGENE
NCBI Gene	12155	ENTREZGENE
PANTHER	PTHR11848	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11848:SF22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Bmp15	PhenoGen
PRINTS	INHIBINA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	BMP15_MOUSE	UniProtKB/Swiss-Prot
	Q3USZ3	ENTREZGENE, UniProtKB/TrEMBL
	Q3UT46	ENTREZGENE
	Q3UWT0_MOUSE	UniProtKB/TrEMBL
	Q9Z0L4	ENTREZGENE
UniProt Secondary	Q3UT46	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype