Insl6 (insulin-like 6) - Rat Genome Database

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Gene: Insl6 (insulin-like 6) Mus musculus
Analyze
Symbol: Insl6
Name: insulin-like 6
RGD ID: 62353
MGI Page MGI
Description: Predicted to enable hormone activity. Acts upstream of or within several processes, including flagellated sperm motility; male gonad development; and spermatid development. Predicted to be located in extracellular region. Is expressed in several structures, including colon; gonad; heart; hemolymphoid system gland; and liver. Orthologous to human INSL6 (insulin like 6).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: insulin-like peptide 6; insulin-like peptide INSL6; relaxin/insulin-like factor 1; RI; RIF1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,298,754 - 29,302,718 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,298,744 - 29,302,756 (-)EnsemblGRCm39 Ensembl
GRCm381929,321,354 - 29,325,318 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,321,344 - 29,325,356 (-)EnsemblGRCm38mm10GRCm38
MGSCv371929,395,844 - 29,399,808 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361929,387,351 - 29,391,315 (-)NCBIMGSCv36mm8
Celera1930,097,916 - 30,101,880 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10598589   PMID:10614671   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15804440   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17971504  
PMID:19520787   PMID:20807758   PMID:21677750   PMID:24952961   PMID:29887522   PMID:34585777  


Genomics

Comparative Map Data
Insl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,298,754 - 29,302,718 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,298,744 - 29,302,756 (-)EnsemblGRCm39 Ensembl
GRCm381929,321,354 - 29,325,318 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,321,344 - 29,325,356 (-)EnsemblGRCm38mm10GRCm38
MGSCv371929,395,844 - 29,399,808 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361929,387,351 - 29,391,315 (-)NCBIMGSCv36mm8
Celera1930,097,916 - 30,101,880 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.82NCBI
INSL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3894,991,976 - 5,185,639 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl95,123,880 - 5,185,647 (-)EnsemblGRCh38hg38GRCh38
GRCh3795,163,868 - 5,185,639 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,153,863 - 5,175,618 (-)NCBINCBI36Build 36hg18NCBI36
Build 3495,153,864 - 5,175,618NCBI
Celera95,089,480 - 5,111,235 (-)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef95,119,294 - 5,141,049 (-)NCBIHuRef
CHM1_195,164,034 - 5,185,789 (-)NCBICHM1_1
T2T-CHM13v2.094,992,955 - 5,190,714 (-)NCBIT2T-CHM13v2.0
Insl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,483,530 - 236,487,065 (-)NCBIGRCr8
mRatBN7.21227,069,958 - 227,073,493 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,069,958 - 227,073,493 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,471,624 - 235,475,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,401,288 - 242,404,815 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,218,731 - 235,222,261 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,473,292 - 247,476,827 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,473,292 - 247,476,827 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,721,416 - 254,724,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,990,534 - 232,994,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11233,154,556 - 233,158,092 (-)NCBI
Celera1224,221,875 - 224,225,410 (-)NCBICelera
Cytogenetic Map1q52NCBI
Insl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554349,349,142 - 9,355,739 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554349,349,033 - 9,355,817 (-)NCBIChiLan1.0ChiLan1.0
INSL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211119,362,748 - 119,434,904 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,368,695 - 119,390,561 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v095,007,158 - 5,029,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.195,192,023 - 5,213,827 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,192,023 - 5,213,827 (-)Ensemblpanpan1.1panPan2
INSL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,457,854 - 93,474,777 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,459,945 - 93,474,793 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,866,056 - 93,882,980 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0194,011,512 - 94,028,434 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,011,678 - 94,028,449 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,643,885 - 93,660,812 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,368,454 - 93,385,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0194,132,819 - 94,149,742 (-)NCBIUU_Cfam_GSD_1.0
Insl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947141,095,258 - 141,105,131 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493650367,933 - 78,496 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,792,787 - 216,823,479 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,792,785 - 216,820,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,534,691 - 242,561,841 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INSL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,345,243 - 74,372,778 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,346,706 - 74,372,729 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603862,743,906 - 62,770,088 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247369,838,781 - 9,848,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Insl6
117 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:41
Interacting mature miRNAs:56
Transcripts:ENSMUST00000052380
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192777198535295381Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse

Markers in Region
RH135780  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381929,321,346 - 29,321,474UniSTSGRCm38
MGSCv371929,395,836 - 29,395,964UniSTSGRCm37
Celera1930,097,908 - 30,098,036UniSTS
Cytogenetic Map19C3UniSTS
cM Map19 UniSTS
UniSTS:237917  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381929,321,509 - 29,321,712UniSTSGRCm38
MGSCv371929,395,999 - 29,396,202UniSTSGRCm37
Celera1930,098,071 - 30,098,274UniSTS
Cytogenetic Map19C3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000052380   ⟹   ENSMUSP00000054488
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,298,744 - 29,302,756 (-)Ensembl
GRCm38.p6 Ensembl1929,321,344 - 29,325,356 (-)Ensembl
RefSeq Acc Id: NM_013754   ⟹   NP_038782
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,298,754 - 29,302,718 (-)NCBI
GRCm381929,321,354 - 29,325,318 (-)ENTREZGENE
MGSCv371929,395,844 - 29,399,808 (-)RGD
Celera1930,097,916 - 30,101,880 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_038782 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD30158 (Get FASTA)   NCBI Sequence Viewer  
  AAH28752 (Get FASTA)   NCBI Sequence Viewer  
  BAB24156 (Get FASTA)   NCBI Sequence Viewer  
  EDL41675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000054488
  ENSMUSP00000054488.4
GenBank Protein Q9QY05 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_038782   ⟸   NM_013754
- Peptide Label: precursor
- UniProtKB: Q9QY05 (UniProtKB/Swiss-Prot),   Q545M1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000054488   ⟸   ENSMUST00000052380
Protein Domains
Insulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QY05-F1-model_v2 AlphaFold Q9QY05 1-191 view protein structure

Promoters
RGD ID:13679210
Promoter ID:EPDNEW_M23755
Type:initiation region
Name:Insl6_1
Description:Mus musculus insulin-like 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381929,325,319 - 29,325,379EPDNEW
RGD ID:6830132
Promoter ID:MM_KWN:26789
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000052380
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361929,399,631 - 29,400,131 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351595 AgrOrtholog
Ensembl Genes ENSMUSG00000050957 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052380 ENTREZGENE
  ENSMUST00000052380.5 UniProtKB/Swiss-Prot
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_pep_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:27356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1351595 ENTREZGENE
NCBI Gene 27356 ENTREZGENE
PANTHER PTHR12004:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RELAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Insulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Insl6 PhenoGen
PIRSF Insulin-like_peptide_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IlGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt INSL6_MOUSE UniProtKB/Swiss-Prot
  Q545M1 ENTREZGENE, UniProtKB/TrEMBL
  Q9QY05 ENTREZGENE