OVOL3 (ovo like zinc finger 3) - Rat Genome Database

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Gene: OVOL3 (ovo like zinc finger 3) Homo sapiens
Analyze
Symbol: OVOL3
Name: ovo like zinc finger 3
RGD ID: 5683924
HGNC Page HGNC:14186
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epidermal cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HOVO3; OVO homolog-like 3; ovo-like 3; ovo-like 3 (Drosophila); ovo-like zinc finger 3; putative transcription factor Ovo-like 2-like; putative transcription factor ovo-like protein 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,111,143 - 36,113,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,111,143 - 36,113,711 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,602,045 - 36,604,613 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,287,925 - 41,296,403 (+)NCBINCBI36Build 36hg18NCBI36
Celera1933,316,285 - 33,318,744 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,107,590 - 33,110,099 (+)NCBIHuRef
CHM1_11936,603,447 - 36,605,955 (+)NCBICHM1_1
T2T-CHM13v2.01938,656,961 - 38,659,529 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (ISA)
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12213202   PMID:15057824   PMID:21873635   PMID:22737237  


Genomics

Comparative Map Data
OVOL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,111,143 - 36,113,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,111,143 - 36,113,711 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,602,045 - 36,604,613 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,287,925 - 41,296,403 (+)NCBINCBI36Build 36hg18NCBI36
Celera1933,316,285 - 33,318,744 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,107,590 - 33,110,099 (+)NCBIHuRef
CHM1_11936,603,447 - 36,605,955 (+)NCBICHM1_1
T2T-CHM13v2.01938,656,961 - 38,659,529 (+)NCBIT2T-CHM13v2.0
Ovol3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39729,932,722 - 29,937,000 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl729,932,864 - 29,935,150 (-)EnsemblGRCm39 Ensembl
GRCm38730,233,297 - 30,237,575 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,233,439 - 30,235,725 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,018,458 - 31,020,478 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36729,942,199 - 29,944,119 (-)NCBIMGSCv36mm8
MGSCv36722,511,594 - 22,513,514 (-)NCBIMGSCv36mm8
Celera724,837,823 - 24,839,843 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.34NCBI
Ovol3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,612,417 - 94,616,053 (-)NCBIGRCr8
mRatBN7.2185,484,956 - 85,488,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,484,956 - 85,488,592 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx190,901,557 - 90,905,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,368,921 - 99,372,542 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,659,818 - 92,663,435 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0191,037,531 - 91,041,167 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl191,038,886 - 91,041,121 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,688,299 - 88,690,534 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0192,174,474 - 92,178,324 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera179,859,395 - 79,863,031 (-)NCBICelera
Cytogenetic Map1q21NCBI
Ovol3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,495,567 - 2,498,508 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,495,567 - 2,498,508 (-)NCBIChiLan1.0ChiLan1.0
OVOL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22042,112,976 - 42,115,735 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11944,096,533 - 44,099,284 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01933,030,285 - 33,032,988 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,777,055 - 41,780,124 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,777,055 - 41,780,124 (+)Ensemblpanpan1.1panPan2
OVOL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,587,569 - 116,594,086 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,587,599 - 116,589,497 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1115,992,945 - 115,999,678 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,190,335 - 117,197,055 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,190,570 - 117,192,468 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,757,730 - 116,764,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,377,910 - 116,384,643 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,433,080 - 117,439,809 (-)NCBIUU_Cfam_GSD_1.0
Ovol3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,357,768 - 11,360,128 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936922128,196 - 130,197 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936922128,196 - 130,197 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OVOL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,478,098 - 45,480,786 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,477,261 - 45,480,822 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,878,391 - 40,882,993 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OVOL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1631,016,622 - 31,020,104 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660738,817,498 - 8,820,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ovol3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,357,829 - 10,359,935 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,355,883 - 10,360,083 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19q12-13.13(chr19:29661858-38114723)x1 copy number loss See cases [RCV000135879] Chr19:29661858..38114723 [GRCh38]
Chr19:30152765..38605363 [GRCh37]
Chr19:34844605..43297203 [NCBI36]
Chr19:19q12-13.13		 pathogenic
GRCh38/hg38 19q12-13.13(chr19:29671324-37902990)x1 copy number loss See cases [RCV000136794] Chr19:29671324..37902990 [GRCh38]
Chr19:30162231..38393630 [GRCh37]
Chr19:34854071..43085470 [NCBI36]
Chr19:19q12-13.13		 pathogenic
GRCh37/hg19 19q13.12-13.13(chr19:36475577-38399402)x3 copy number gain See cases [RCV000240597] Chr19:36475577..38399402 [GRCh37]
Chr19:19q13.12-13.13		 uncertain significance
GRCh37/hg19 19q13.12(chr19:36147111-37249653)x1 copy number loss See cases [RCV000511504] Chr19:36147111..37249653 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.11-13.12(chr19:35111811-37744992) copy number loss Generalized epilepsy with febrile seizures plus, type 1 [RCV000767768] Chr19:35111811..37744992 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
GRCh37/hg19 19q13.12(chr19:36570287-36655341)x3 copy number gain not provided [RCV000846132] Chr19:36570287..36655341 [GRCh37]
Chr19:19q13.12		 uncertain significance
NC_000019.9:g.(?_33167170)_(36643309_?)dup duplication Hereditary spastic paraplegia 75 [RCV003107659] Chr19:33167170..36643309 [GRCh37]
Chr19:19q13.11-13.12		 uncertain significance
GRCh37/hg19 19p13.11-q13.2(chr19:19546923-41313229)x3 copy number gain Specific learning disability [RCV001801194] Chr19:19546923..41313229 [GRCh37]
Chr19:19p13.11-q13.2		 pathogenic
NC_000019.9:g.(?_35521725)_(36643309_?)del deletion Brugada syndrome 5 [RCV001910265] Chr19:35521725..36643309 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19q13.12(chr19:36312941-36751702)x3 copy number gain not provided [RCV003485199] Chr19:36312941..36751702 [GRCh37]
Chr19:19q13.12		 uncertain significance
Single allele deletion not provided [RCV003448708] Chr19:35225414..37357598 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q13.12(chr19:36451071-36752221)x3 copy number gain not specified [RCV003986106] Chr19:36451071..36752221 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19q11-13.2(chr19:28271146-41508851)x3 copy number gain not specified [RCV003986115] Chr19:28271146..41508851 [GRCh37]
Chr19:19q11-13.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:908
Count of miRNA genes:420
Interacting mature miRNAs:464
Transcripts:ENST00000262637, ENST00000585332, ENST00000586670
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 3 105
Low 123 17 220 27 371 29 365 25 542 35 533 263 4 21 170
Below cutoff 1813 1737 1107 406 871 273 2931 1372 2585 236 693 1044 139 841 1876 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000585332   ⟹   ENSP00000465620
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1936,111,203 - 36,113,711 (+)Ensembl
RefSeq Acc Id: ENST00000633214   ⟹   ENSP00000487603
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1936,111,143 - 36,113,711 (+)Ensembl
RefSeq Acc Id: NM_001302757   ⟹   NP_001289686
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,111,143 - 36,113,711 (+)NCBI
CHM1_11936,603,447 - 36,605,955 (+)NCBI
T2T-CHM13v2.01938,656,961 - 38,659,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027191   ⟹   XP_016882680
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381936,111,203 - 36,113,711 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054321909   ⟹   XP_054177884
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01938,657,021 - 38,659,529 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001289686 (Get FASTA)   NCBI Sequence Viewer  
  XP_016882680 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177884 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB51180 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000465620.2
  ENSP00000487603
  ENSP00000487603.1
GenBank Protein O00110 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001289686   ⟸   NM_001302757
- UniProtKB: O00110 (UniProtKB/Swiss-Prot),   A0A0J9YVN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016882680   ⟸   XM_017027191
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000465620   ⟸   ENST00000585332
RefSeq Acc Id: ENSP00000487603   ⟸   ENST00000633214
RefSeq Acc Id: XP_054177884   ⟸   XM_054321909
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O00110-F1-model_v2 AlphaFold O00110 1-214 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14186 AgrOrtholog
COSMIC OVOL3 COSMIC
Ensembl Genes ENSG00000105261 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000585332.3 UniProtKB/TrEMBL
  ENST00000633214 ENTREZGENE
  ENST00000633214.2 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
GTEx ENSG00000105261 GTEx
HGNC ID HGNC:14186 ENTREZGENE
Human Proteome Map OVOL3 Human Proteome Map
InterPro Ovo-like UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report hsa:728361 UniProtKB/Swiss-Prot
NCBI Gene OVOL3 ENTREZGENE
OMIM 616442 OMIM
PANTHER PTHR10032 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR OVO-LIKE PROTEIN 3-RELATED UniProtKB/Swiss-Prot
Pfam zf-H2C2_2 UniProtKB/Swiss-Prot
PharmGKB PA166048946 PharmGKB
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A0A0J9YVN9 ENTREZGENE
  A0AA75L0V4_HUMAN UniProtKB/TrEMBL
  O00110 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0J9YVN9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 OVOL3  ovo like zinc finger 3    ovo-like zinc finger 3  Symbol and/or name change 5135510 APPROVED
2013-10-22 OVOL3  ovo-like zinc finger 3    ovo-like 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED