Dthd1 (death domain containing 1) - Rat Genome Database

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Gene: Dthd1 (death domain containing 1) Mus musculus
Analyze
Symbol: Dthd1
Name: death domain containing 1
RGD ID: 5144970
MGI Page MGI
Description: Orthologous to human DTHD1 (death domain containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: death domain-containing protein 1; Gm17384
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39562,968,999 - 63,045,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl562,969,017 - 63,045,651 (+)EnsemblGRCm39 Ensembl
GRCm38562,811,656 - 62,888,318 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl562,811,674 - 62,888,308 (+)EnsemblGRCm38mm10GRCm38
MGSCv37563,205,062 - 63,279,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera560,111,159 - 60,188,203 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map532.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:12040188   PMID:38355793  


Genomics

Comparative Map Data
Dthd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39562,968,999 - 63,045,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl562,969,017 - 63,045,651 (+)EnsemblGRCm39 Ensembl
GRCm38562,811,656 - 62,888,318 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl562,811,674 - 62,888,308 (+)EnsemblGRCm38mm10GRCm38
MGSCv37563,205,062 - 63,279,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera560,111,159 - 60,188,203 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map532.04NCBI
DTHD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38436,281,616 - 36,347,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl436,281,616 - 36,347,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37436,283,238 - 36,349,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36435,959,791 - 36,021,841 (+)NCBINCBI36Build 36hg18NCBI36
Celera436,722,811 - 36,786,900 (+)NCBICelera
Cytogenetic Map4p14NCBI
HuRef435,609,534 - 35,672,974 (+)NCBIHuRef
CHM1_1436,282,366 - 36,345,554 (+)NCBICHM1_1
T2T-CHM13v2.0436,250,598 - 36,316,504 (+)NCBIT2T-CHM13v2.0
Dthd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81450,773,694 - 50,877,217 (-)NCBIGRCr8
mRatBN7.21446,670,438 - 46,673,183 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.01448,612,893 - 48,677,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1448,629,983 - 48,676,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01448,781,234 - 48,890,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41450,439,737 - 50,593,278 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1445,908,465 - 45,975,608 (-)NCBICelera
Cytogenetic Map14p11NCBI
Dthd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544310,443,547 - 10,501,424 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544310,444,916 - 10,501,215 (-)NCBIChiLan1.0ChiLan1.0
DTHD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2336,461,370 - 36,525,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1436,650,386 - 36,714,052 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0430,598,434 - 30,664,305 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1436,460,761 - 36,522,566 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl436,460,507 - 36,522,524 (+)Ensemblpanpan1.1panPan2
DTHD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1375,542,333 - 75,603,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl375,542,653 - 75,606,145 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha378,029,475 - 78,105,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0376,324,654 - 76,400,068 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl376,324,514 - 76,387,656 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1375,589,354 - 75,665,709 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0375,746,212 - 75,821,795 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0376,121,514 - 76,197,308 (-)NCBIUU_Cfam_GSD_1.0
Dthd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528541,635,889 - 41,697,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364824,603,473 - 4,661,118 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364824,603,473 - 4,661,598 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DTHD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl827,998,500 - 28,072,309 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1827,997,486 - 28,073,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2829,364,244 - 29,438,552 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DTHD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12713,932,420 - 14,001,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2713,935,413 - 13,998,489 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604760,382,047 - 60,448,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dthd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248404,849,426 - 4,926,891 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248404,849,668 - 4,925,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dthd1
3290 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:89
Interacting mature miRNAs:91
Transcripts:ENSMUST00000170704
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
1300926Hpi2_mhepatic PMN infiltration 2 (mouse)Not determined53758148864806579Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
13464245Ahl12_mage related hearing loss, early onset 12 (mouse)53811168172111798Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4141473Lfnq1_mlung function QTL 1 (mouse)Not determined5441111064579648Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000170704   ⟹   ENSMUSP00000131534
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl562,971,166 - 63,045,651 (+)Ensembl
GRCm38.p6 Ensembl562,813,823 - 62,888,308 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238474   ⟹   ENSMUSP00000158635
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl562,969,017 - 63,045,651 (+)Ensembl
GRCm38.p6 Ensembl562,811,674 - 62,888,308 (+)Ensembl
RefSeq Acc Id: NM_001170705   ⟹   NP_001164176
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39562,968,999 - 63,045,661 (+)NCBI
GRCm38562,811,656 - 62,888,318 (+)NCBI
MGSCv37563,205,062 - 63,279,557 (+)ENTREZGENE
Celera560,111,159 - 60,188,203 (+)ENTREZGENE
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001164176 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL37699 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000131534.2
  ENSMUSP00000158635
  ENSMUSP00000158635.2
Reference Protein Sequences
RefSeq Acc Id: NP_001164176   ⟸   NM_001170705
- UniProtKB: A0A571BG01 (UniProtKB/TrEMBL),   E9PZX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000158635   ⟸   ENSMUST00000238474
RefSeq Acc Id: ENSMUSP00000131534   ⟸   ENSMUST00000170704
Protein Domains
Death   ZU5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A571BG01-F1-model_v2 AlphaFold A0A571BG01 1-905 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:4937018 AgrOrtholog
Ensembl Genes ENSMUSG00000090326 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000170704.2 UniProtKB/TrEMBL
  ENSMUST00000238474 ENTREZGENE
  ENSMUST00000238474.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.60.220.30 UniProtKB/TrEMBL
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  ZU5_dom UniProtKB/TrEMBL
KEGG Report mmu:100322896 UniProtKB/TrEMBL
MGD MGI:4937018 ENTREZGENE
NCBI Gene 100322896 ENTREZGENE
PANTHER BA1-643 UniProtKB/TrEMBL
  DEATH DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
PhenoGen Dthd1 PhenoGen
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt A0A571BG01 ENTREZGENE, UniProtKB/TrEMBL
  E9PZX1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-07 Dthd1  death domain containing 1  Gm17384  predicted gene, 17384  Symbol and/or name change 5135510 APPROVED