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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-hydroxy-5alpha-androstan-3-one | decreases expression | ISO | RGD:1551168 | 6480464 | Dihydrotestosterone results in decreased expression of TSG101 mRNA | CTD | PMID:17023530 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1551168 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TSG101 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1551168 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TSG101 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TSG101 mRNA | CTD | PMID:22298810 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1349732 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of TSG101 mRNA | CTD | PMID:12419474 | ciguatoxin CTX1B | affects expression | ISO | RGD:1551168 | 6480464 | Ciguatoxins affects the expression of TSG101 mRNA | CTD | PMID:18353800 | doxorubicin | affects response to substance | ISO | RGD:1349732 | 6480464 | TSG101 affects the susceptibility to Doxorubicin | CTD | PMID:15044860 | paracetamol | affects expression | ISO | RGD:1551168 | 6480464 | Acetaminophen affects the expression of TSG101 mRNA | CTD | PMID:17562736 | quercetin | increases expression | ISO | RGD:1349732 | 6480464 | Quercetin results in increased expression of TSG101 mRNA | CTD | PMID:15309432 | resveratrol | increases expression | ISO | RGD:1349732 | 6480464 | resveratrol results in increased expression of TSG101 mRNA | CTD | PMID:15767336 | resveratrol | increases expression | ISO | RGD:1551168 | 6480464 | resveratrol results in increased expression of TSG101 mRNA | CTD | PMID:11588890 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1349732 | 6480464 | tert-Butylhydroperoxide results in decreased expression of TSG101 mRNA | CTD | PMID:12419474 | trans-resveratrol | increases expression | ISO | RGD:1349732 | 6480464 | resveratrol results in increased expression of TSG101 mRNA | CTD | PMID:15767336 | trans-resveratrol | increases expression | ISO | RGD:1551168 | 6480464 | resveratrol results in increased expression of TSG101 mRNA | CTD | PMID:11588890 | vincristine | affects response to substance | ISO | RGD:1349732 | 6480464 | TSG101 affects the susceptibility to Vincristine | CTD | PMID:15044860 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Endocytosis |
| Pathway Interaction Database | Glucocorticoid receptor regulatory network (PID:200091) |
| Internalization of ErbB1 (PID:200171) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Endocytosis |
| Pathway Interaction Database | Glucocorticoid receptor regulatory network (PID:200091) |
| Internalization of ErbB1 (PID:200171) | |
References - curated| 1. |
Burgdorf S, etal., J Biol Chem 2004 Apr 23;279(17):17524-34. Epub 2004 Feb 2. |
| 2. |
Chang JG, etal., Br J Cancer. 1999 Feb;79(3-4):445-50. |
| 3. |
Klaes R, etal., Eur J Cancer. 1999 May;35(5):733-7. |
| 4. |
Leithe E, etal., J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. Epub 2009 Oct 6. |
| 5. |
Li L, etal., Cell. 1997 Jan 10;88(1):143-54. |
| 6. |
Lo YF, etal., Breast Cancer Res Treat. 2000 Apr;60(3):259-66. |
| 7. |
MGD data from the GO Consortium |
| 8. |
O'Boyle JD, etal., Gynecol Oncol. 1999 Dec;75(3):401-5. |
| 9. |
Oh KB, etal., Oncogene. 2007 Aug 30;26(40):5950-9. Epub 2007 Mar 19. |
| 10. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 11. |
RGD automated data pipeline |
| 12. |
RGD automated import pipeline for gene-chemical interactions |
| 13. |
RGD Automated Pipelines |
| 14. |
Rusten TE and Stenmark H, J Cell Sci. 2009 Jul 1;122(Pt 13):2179-83. |
| 15. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 16. |
Sun Z, etal., Oncogene. 1997 Dec 18;15(25):3121-5. |
| 17. |
Turpin E, etal., Oncogene. 1999 Dec 16;18(54):7834-7. |
| 18. |
Young TW, etal., Clin Cancer Res. 2007 Jul 1;13(13):3848-54. |
References - uncuratedRGD Disease Portals| Tsg101 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Tsg101 (Rattus norvegicus) |
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| TSG101 (Homo sapiens) |
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| Tsg101 (Mus musculus) |
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Position Markers| D1Rat267 |
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| RH130601 |
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| AU047244 |
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| AW140530 |
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| BI276330 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_181628 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06004846 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06004847 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01005086 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01005087 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY293306 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC070951 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473979 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231102 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_181628 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_853659 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_853659 | (Get FASTA) |
| GenBank Protein | AAH70951 | (Get FASTA) |
| AAP45008 | (Get FASTA) | |
| EDM07247 | (Get FASTA) | |
| Q6IRE4 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000013381 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000018194 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000018194 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 292925 | ENTREZGENE |
| Gene3D-CATH | UBQ-conjugat_E2 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 4584 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7100763 | IMAGE-MGC_LOAD |
| InterPro | Steadiness_box | UniProtKB/Swiss-Prot |
| Tsg101 | UniProtKB/Swiss-Prot | |
| UBQ-conjugat/RWD-like | UniProtKB/Swiss-Prot | |
| IPI | IPI00421916 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:292925 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:91392 | IMAGE-MGC_LOAD |
| Pfam | UEV | UniProtKB/Swiss-Prot |
| Vps23_core | UniProtKB/Swiss-Prot | |
| PROSITE | PS51312 | UniProtKB/Swiss-Prot |
| UEV | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | UBQ-conjugat/RWD-like | UniProtKB/Swiss-Prot |
| UniGene | Rn.7410 | ENTREZGENE |
| UniProt | F1LRB7_RAT | UniProtKB/TrEMBL |
| TS101_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Tsg101 | Tumor supressor gene | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_physical_interaction | binds apoptosis-antagonizing transcription factor (AATF) | 1300501 |
| More on Tsg101 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3909 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.