Akr1a1 (aldo-keto reductase family 1 member A1) - Rat Genome Database

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Pathways
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Gene: Akr1a1 (aldo-keto reductase family 1 member A1) Heterocephalus glaber
Analyze
Symbol: Akr1a1
Name: aldo-keto reductase family 1 member A1
RGD ID: 18936367
Description: ENCODES a protein that exhibits all-trans-retinol dehydrogenase (NAD+) activity (ortholog); INVOLVED IN aldehyde catabolic process (ortholog); D-glucuronate catabolic process (ortholog); L-ascorbic acid biosynthetic process (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; prostaglandin biosynthetic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); breast cancer (ortholog); Carcinogenesis (ortholog); FOUND IN cytosol (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Alcohol dehydrogenase; alcohol dehydrogenase (NADP(+)); alcohol dehydrogenase [NADP(+)]
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,462,693 - 1,474,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,463,201 - 1,474,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
plasma membrane  (IEA)
synapse  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Akr1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,462,693 - 1,474,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,463,201 - 1,474,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
AKR1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,550,826 - 45,570,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,550,543 - 45,570,049 (+)EnsemblGRCh38hg38GRCh38
GRCh37146,016,498 - 46,035,721 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,789,085 - 45,808,308 (+)NCBINCBI36Build 36hg18NCBI36
Build 34145,685,590 - 45,704,813NCBI
Celera144,300,464 - 44,319,706 (+)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,127,818 - 44,147,063 (+)NCBIHuRef
CHM1_1146,133,579 - 46,152,870 (+)NCBICHM1_1
T2T-CHM13v2.0145,423,192 - 45,442,415 (+)NCBIT2T-CHM13v2.0
Akr1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,493,707 - 116,508,871 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,493,707 - 116,508,877 (-)EnsemblGRCm39 Ensembl
GRCm384116,636,510 - 116,651,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,636,510 - 116,651,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv374116,309,115 - 116,324,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,134,442 - 116,149,583 (-)NCBIMGSCv36mm8
Celera4115,370,207 - 115,385,626 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.26NCBI
Akr1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,329,605 - 135,367,037 (-)NCBIGRCr8
mRatBN7.25130,092,945 - 130,130,277 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,092,732 - 130,113,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,717,057 - 132,734,057 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,471,650 - 134,488,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,494,047 - 134,511,049 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,482,068 - 135,498,693 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,482,068 - 135,498,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,278,242 - 139,294,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,920,561 - 136,937,422 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,925,785 - 136,942,923 (-)NCBI
Celera5128,620,481 - 128,637,092 (-)NCBICelera
Cytogenetic Map5q35NCBI
Akr1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,714,717 - 12,729,662 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,715,238 - 12,729,034 (-)NCBIChiLan1.0ChiLan1.0
AKR1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,239,683 - 181,257,580 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,381,197 - 180,399,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,853,867 - 44,871,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,211,859 - 46,230,072 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,211,859 - 46,230,072 (+)Ensemblpanpan1.1panPan2
AKR1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,792,398 - 14,808,805 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,742,012 - 14,808,592 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,913,465 - 14,929,729 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,947,192 - 14,963,694 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,896,489 - 14,963,353 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,744,329 - 14,760,787 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,814,053 - 14,828,473 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,884,045 - 14,900,543 (-)NCBIUU_Cfam_GSD_1.0
Akr1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,855,920 - 60,872,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,680,676 - 26,697,214 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,680,736 - 26,696,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,811,247 - 165,824,896 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,811,245 - 165,825,168 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AKR1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,228,348 - 87,245,511 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,228,189 - 87,245,466 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,719,096 - 29,738,521 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000003303   ⟹   ENSHGLP00000003248
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249061,462,693 - 1,474,214 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000003304   ⟹   ENSHGLP00000003249
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249061,462,693 - 1,474,214 (+)Ensembl
RefSeq Acc Id: XM_004872931   ⟹   XP_004872988
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249061,463,238 - 1,474,001 (+)NCBI
RefSeq Acc Id: XM_004872932   ⟹   XP_004872989
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249061,463,205 - 1,474,001 (+)NCBI
RefSeq Acc Id: XM_004872933   ⟹   XP_004872990
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249061,463,238 - 1,474,001 (+)NCBI
RefSeq Acc Id: XM_021250775   ⟹   XP_021106434
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249061,463,201 - 1,474,001 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004872988 (Get FASTA)   NCBI Sequence Viewer  
  XP_004872989 (Get FASTA)   NCBI Sequence Viewer  
  XP_004872990 (Get FASTA)   NCBI Sequence Viewer  
  XP_021106434 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB01599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000003248
  ENSHGLP00000003249
GenBank Protein JAO02419 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021106434   ⟸   XM_021250775
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004872989   ⟸   XM_004872932
- Peptide Label: isoform X1
- UniProtKB: G5AX38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004872988   ⟸   XM_004872931
- Peptide Label: isoform X1
- UniProtKB: G5AX38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004872990   ⟸   XM_004872933
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000003248   ⟸   ENSHGLT00000003303
RefSeq Acc Id: ENSHGLP00000003249   ⟸   ENSHGLT00000003304


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002413 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000003303 ENTREZGENE
  ENSHGLT00000003304 ENTREZGENE
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR UniProtKB/TrEMBL
  AKR1A UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101710959 UniProtKB/TrEMBL
NCBI Gene Akr1a1 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER A1 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt G5AX38 ENTREZGENE, UniProtKB/TrEMBL